Aspirin-induced gastric mucosal damage in rats: Cimetidine and degly-cyhrrhizinated liquorice together give greater protection than low doses of either drug alone

Bennett, A. B.; Clark-Wibberley, T; Stamford, I F; Wright, Joyce

doi:10.1111/j.2042-7158.1980.tb12879.x

Cited by 24 publications

(13 citation statements)

References 3 publications

(1 reference statement)

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“…Saitoh et al (1976) isolated new isoflavonoids and chalcones from the fraction FM 100, which could Scarlat et al, 1985 contribute to the anti-ulcer activity of liquorice. Simple derivatives of glycyrrhetinic acid (the genin of glycyrrhizinic acid) such as carbenoxolone (an ester derivative) and deglycyrrhizinized liquorice (DGL), have been used extensively in gastric ulcer treatment (Habib et al, 1979;Bennett et al, 1980). Carbenoxolone derives from the hydrolysis of glycyrrhizinic acid after its extraction from liquorice root.…”

Section: Liquoricementioning

confidence: 99%

The plant kingdom as a source of anti-ulcer remedies

2000

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Section: Liquoricementioning

confidence: 99%

The plant kingdom as a source of anti-ulcer remedies

2000

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“…In an earlier in vivo study, deglycyrrhizinated licorice (DGL) was found to be effective in alleviation of ulcer in aspirin-induced gastric mucosal damage in rats [21]. The curative effect of DGL in gastric ulcer patients was confirmed during 1970s by clinical trials [22, 23].…”

Section: Introductionmentioning

confidence: 99%

An Extract ofGlycyrrhiza glabra(GutGard) Alleviates Symptoms of Functional Dyspepsia: A Randomized, Double-Blind, Placebo-Controlled Study

Raveendra¹,

Jayachandra²,

Srinivasa³

et al. 2012

Evidence-Based Complementary and Alternative Medicine

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A randomized, double-blind, placebo-controlled study was conducted to evaluate the efficacy of GutGard, an extract of Glycyrrhiza glabra, in patients with functional dyspepsia. The primary outcome variables of the study were the change in the severity symptoms and the global assessment of efficacy. The quality of life was evaluated as a secondary outcome measure. The patients received either placebo or GutGard (75 mg twice daily) for 30 days. Efficacy was evaluated in terms of change in the severity of symptoms (as measured by 7-point Likert scale), the global assessment of efficacy, and the assessment of quality of life using the short-form Nepean Dyspepsia Index. In comparison with placebo, GutGard showed a significant decrease (P ≤ .05) in total symptom scores on day 15 and day 30, respectively. Similarly, GutGard showed marked improvement in the global assessment of efficacy in comparison to the placebo. The GutGard group also showed a significant decrease (P ≤ .05) in the Nepean dyspepsia index on day 15 and 30, respectively, when compared to placebo. GutGard was generally found to be safe and well-tolerated by all patients. GutGard has shown significant efficacy in the management of functional dyspepsia.

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“…Different results of in vivo and in vitro studies might also be explained by the fact that metabolism of GL into GA is not expected to occur in cell culture as GL is usually metabolised in vivo by intestinal flora or liver enzymes (Kim, Jang, Lee, Jung, & Lee, ). Furthermore, ingredients other than GL and GA might influence the barrier function since even deglycyrrhizinated liquorice could successfully be used against gastrointestinal ulcers in rats (Bennett, Clark‐Wibberley, Stamford, & Wright, ) and human patients (Larkworthy & Holgate, ). These other ingredients might include flavones or isoflavones, which have been reported to affect the barrier function (Yang, et al, ).…”

Section: Discussionmentioning

confidence: 99%

Influence of phytogenics on recovery of the barrier function of intestinal porcine epithelial cells after a calcium switch

Bachinger¹,

Mayer²,

Kaschubek

et al. 2018

Animal Physiology Nutrition

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Background The gut barrier is essential for animal health as it prevents the passage of potentially harmful foreign substances. The epithelial tight junctions support the intestinal barrier and can be disrupted by stress caused, for example, by pathogens or dietary or environmental factors, predisposing the host to disease. In animal husbandry, phytogenics (plant‐derived feed additives) are used to support and maintain growth, feed efficiency and health. Therefore, several phytogenics were tested in vitro for their influence on the barrier function recovery of intestinal porcine epithelial cells (IPEC‐J2) after disruption, particularly on the abundance of tight junction proteins. Results IPEC‐J2 treated with 1,000 µg/ml liquorice root extract, 80 µg/ml plant powder mix, or 80 µg/ml angelica root powder showed significantly higher trans‐epithelial electric resistance (TEER) 24 hr after tight junction disruption via a calcium switch assay than the control. In contrast, cells treated with 1,000 µg/ml oak bark extract showed a significantly lower TEER after 6 hr but not at later time points. The increased TEER caused by the liquorice root extract correlated with an increase in the abundance of the tight junction protein claudin‐4. Conclusions This study suggests potential beneficial effects of liquorice and angelica root extracts on the gut barrier function when used as feed additives for livestock. Further studies, especially in vivo, are necessary to confirm these findings.

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Aspirin-induced gastric mucosal damage in rats: Cimetidine and degly-cyhrrhizinated liquorice together give greater protection than low doses of either drug alone

Cited by 24 publications

References 3 publications

The plant kingdom as a source of anti-ulcer remedies

The plant kingdom as a source of anti-ulcer remedies

An Extract ofGlycyrrhiza glabra(GutGard) Alleviates Symptoms of Functional Dyspepsia: A Randomized, Double-Blind, Placebo-Controlled Study

Influence of phytogenics on recovery of the barrier function of intestinal porcine epithelial cells after a calcium switch

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