Aspirin effect on bone remodeling and skeletal regeneration: Review article

Fattahi, Roya; Mohebichamkhorami, Fariba; Khammarnia, Mohammad; Soleimani, Masoud; Hosseinzadeh, Simzar

doi:10.1016/j.tice.2022.101753

Cited by 10 publications

(9 citation statements)

References 113 publications

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“…91 Previous studies reported that local delivery of aspirin via a scaffold could upregulate osteogenic proteins and the mineralization of stem cells under inflammatory conditions. 92,93 Accordingly, as expected, after implantation of ASA@tHALLG nanocomposites into defects, the released aspirin from the GCP assembly enhanced the osteogenic potential of hPDLSCs at bone-ligament interfaces, eventually leading to an accelerated remodeling of periodontal bone tissue. Moreover, it is noted that due to the anti-inflammatory activity of aspirin, the host inflammatory response was markedly inhibited during the healing process of the defects treated with ASA@tHALLG nanocomposites, as indicated by the significantly reduced positive staining areas of TNF-α and IL-1β (Figure S3) in the defect regions.…”

Section: Dovepresssupporting

confidence: 61%

“… 67 , 101 , 102 Cun-Yu Wang et al previously proved that activation of NF-κB can inhibit osteogenic differentiation of stem cells by promoting β-catenin degradation. 98 Based on above inflammation mediated regulatory mechanism, aspirin released from ASA@tHALLG nanocomposites may interfere NF-κB signaling pathway through inhibition of inflammatory response, 57 , 92 in turn enhancing Wnt-dependent osteogenic commitment of PDLSCs, the critical cells responsible for regeneration of periodontal tissue, in inflammatory microenvironment. 67 , 103 Therefore, in agreement with the in vitro experiments, the results obtained from the in vivo studies demonstrated that the ASA@tHALLG nanocomposites possessed an excellent capacity to facilitate the reconstruction of periodontal bone tissue, with great potential for applications in periodontal and bone tissue engineering.…”

Section: Resultsmentioning

confidence: 99%

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A Biomimetic Smart Nanoplatform as “Inflammation Scavenger” for Regenerative Therapy of Periodontal Tissue

Chen¹,

Zhang²,

He³

et al. 2022

IJN

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The functional reconstruction of periodontal tissue defects remains a clinical challenge due to excessive and prolonged host response to various endogenous and exogenous pro-inflammatory stimuli. Thus, a biomimetic nanoplatform with the capability of modulating inflammatory response in a microenvironment-responsive manner is attractive for regenerative therapy of periodontal tissue. Methods: Herein, a facile and green design of engineered bone graft materials was developed by integrating a biomimetic apatite nanocomposite with a smart-release coating, which could realize inflammatory modulation by "on-demand" delivery of the antiinflammatory agent through a pH-sensing mechanism. Results: In vitro and in vivo experiments demonstrated that this biocompatible nanoplatform could facilitate the clearance of reactive oxygen species in human periodontal ligament stem cells under inflammatory conditions via inhibiting the production of endogenous proinflammatory mediators, in turn contributing to the enhanced healing efficacy of periodontal tissue. Moreover, this system exhibited effective antimicrobial activity against common pathogenic bacteria in the oral cavity, which is beneficial for the elimination of exogenous pro-inflammatory factors from bacterial infection during healing of periodontal tissue. Conclusion:The proposed strategy provides a versatile apatite nanocomposite as a promising "inflammation scavenger" and propels the development of intelligent bone graft materials for periodontal and orthopedic applications.

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Section: Dovepresssupporting

confidence: 61%

Section: Resultsmentioning

confidence: 99%

A Biomimetic Smart Nanoplatform as “Inflammation Scavenger” for Regenerative Therapy of Periodontal Tissue

Chen¹,

Zhang²,

He³

et al. 2022

IJN

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“…Invaluable qualities such as interconnected porous morphology and architecture similar to extracellular matrix (ECM), irreplaceable water retention capacity, drugs and growth factors delivery effect, and biodegradability enable hydrogel to adapt to specific physical and soft tissue regeneration environment ( Han et al, 2021 ; Sreekumaran et al, 2021 ; Sun et al, 2022 ). Furthermore, some attention has been fortunately drawn to the roles of the non-steroidal anti-inflammatory drug (NSAIDs) of aspirin, since it is used to alleviate the inflammation and activate osteoblasts in the surgical site within the concentration range of 50–300 μg/mL ( Fattahi et al, 2022 ). Studies have confirmed that an appropriate dose of aspirin can improve trabecular bone structure, bone mineral density, and bone mechanical strength ( Tao et al, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

Osteogenic and anti-inflammatory effect of the multifunctional bionic hydrogel scaffold loaded with aspirin and nano-hydroxyapatite

Xiaowen

Yang

et al. 2023

Front. Bioeng. Biotechnol.

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Although tissue engineering offered new approaches to repair bone defects, it remains a great challenge to create a bone-friendly microenvironment and rebuild bone tissue rapidly by a scaffold with a bionic structure. In this study, a multifunctional structurally optimized hydrogel scaffold was designed by integrating polyvinyl alcohol (PVA), gelatin (Gel), and sodium alginate (SA) with aspirin (ASA) and nano-hydroxyapatite (nHAP). The fabrication procedure is through a dual-crosslinking process. The chemical constitution, crystal structure, microstructure, porosity, mechanical strength, swelling and degradation property, and drug-release behavior of the hydrogel scaffold were analyzed. Multi-hydrogen bonds, electrostatic interactions, and strong “egg-shell” structure contributed to the multi-network microstructure, bone tissue-matched properties, and desirable drug-release function of the hydrogel scaffold. The excellent performance in improving cell viability, promoting cell osteogenic differentiation, and regulating the inflammatory microenvironment of the prepared hydrogel scaffold was verified using mouse pre-osteoblasts (MC3T3-E1) cells. And the synergistic osteogenic and anti-inflammatory functions of aspirin and nano-hydroxyapatite were also verified. This study provided valuable insights into the design, fabrication, and biological potential of multifunctional bone tissue engineering materials with the premise of constructing a bone-friendly microenvironment.

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“…It can also inhibit the expression of nuclear-factor-κB-mediated inflammatory cytokines (e.g., TNF-α), which has important anti-inflammatory effects [ 36 , 37 , 38 , 39 ]. Aspirin is widely used in bone regeneration [ 40 ]. Studies have confirmed that aspirin can promote the osteogenic differentiation of mesenchymal stem cells and inhibits the expression of inflammatory factors to activate osteoblasts and inhibit osteoclasts [ 41 ].…”

Section: Discussionmentioning

confidence: 99%

Anti-Inflammatory and Mineralization Effects of an ASP/PLGA-ASP/ACP/PLLA-PLGA Composite Membrane as a Dental Pulp Capping Agent

Yan¹,

Yang

Liu³

et al. 2022

JFB

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Dental pulp is essential for the development and long-term preservation of teeth. Dental trauma and caries often lead to pulp inflammation. Vital pulp therapy using dental pulp-capping materials is an approach to preserving the vitality of injured dental pulp. Most pulp-capping materials used in clinics have good biocompatibility to promote mineralization, but their anti-inflammatory effect is weak. Therefore, the failure rate will increase when dental pulp inflammation is severe. The present study developed an amorphous calcium phosphate/poly (L-lactic acid)-poly (lactic-co-glycolic acid) membrane compounded with aspirin (hereafter known as ASP/PLGA-ASP/ACP/PLLA-PLGA). The composite membrane, used as a pulp-capping material, effectively achieved the rapid release of high concentrations of the anti-inflammatory drug aspirin during the early stages as well as the long-term release of low concentrations of aspirin and calcium/phosphorus ions during the later stages, which could repair inflamed dental pulp and promote mineralization. Meanwhile, the composite membrane promoted the proliferation of inflamed dental pulp stem cells, downregulated the expression of inflammatory markers, upregulated the expression of mineralization-related markers, and induced the formation of stronger reparative dentin in the rat pulpitis model. These findings indicate that this material may be suitable for use as a pulp-capping material in clinical applications.

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Aspirin effect on bone remodeling and skeletal regeneration: Review article

Cited by 10 publications

References 113 publications

A Biomimetic Smart Nanoplatform as “Inflammation Scavenger” for Regenerative Therapy of Periodontal Tissue

A Biomimetic Smart Nanoplatform as “Inflammation Scavenger” for Regenerative Therapy of Periodontal Tissue

Osteogenic and anti-inflammatory effect of the multifunctional bionic hydrogel scaffold loaded with aspirin and nano-hydroxyapatite

Anti-Inflammatory and Mineralization Effects of an ASP/PLGA-ASP/ACP/PLLA-PLGA Composite Membrane as a Dental Pulp Capping Agent

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