Aspirin Does Not Increase Bleeding and Allogeneic Blood Transfusion in Coronary Artery Surgery

Abstract

Aspirin does not increase bleeding or increase the need for allogeneic blood transfusion in coronary artery surgery.

The use of preoperative aspirin in cardiac surgery: A systematic review and meta-analysis

“…Pooling the results of both RCTs and observational studies, preoperative aspirin did not show any substantial difference in the rates of surgical re‐exploration due to bleeding (OR 1.02; 95%CI 0.86‐1.21; P = 0.79; I 2 = 0 %; P heterogeneity = 0.83) (Figure ). The evidence was derived from the analysis of 26 146 patients, of who 94.11% underwent an isolated CABG, 0.61% underwent CABG +/− concomitant heart valve surgery, and 4.5% underwent valve surgery.…”

“…Pooling the results of both RCTs and observational studies, preoperative aspirin did not show any statistically significant effect on perioperative MI (OR 0.91; 95%CI 0.78‐1.27; P = 0.25; I 2 = 0 %; P heterogeneity = 0.76) (Figure ). A sum of 23, 458 patients was reported pooling the results of eight RCTs and five observational studies where 95.51% of the patients underwent CABG with or without concomitant heart valve surgery.…”

“…A total of 3922 patients from 12 RCTs and 30 893 patients coming from 28 observational studies met our inclusion criteria and were included in the meta‐analysis. Characteristics of the studies are presented in Tables and .…”

“…Nineteen observational studies reported PRBC transfusion rates. The analysis was based on the results from 18 392 patients.…”

“…Pooling the results, no difference was observed in the rates of PRBC transfusions (MD 0.08 unit; 95%CI −0.05 to 0.21; P = 0.24), although heterogeneity was found to be significant ( I 2 = 61%; P heterogeneity = 0.0003) (Figure ). Eight observational studies reported on the administration doses of ≤160 mg/d aspirin, with a sum of 3158 patients. The analysis showed no difference in the rates of PRBC transfusions between preoperative aspirin and placebo groups (MD −0.04 unit; 95%CI −0.23 to 0.15; P = 0.68; I 2 = 31%; P heterogeneity = 0.18) (Figure ).…”