Aspirin desensitization treatment of aspirin-sensitive patients with rhinosinusitis-asthma: Long-term outcomes

Stevenson, Donald D.; Hankammer, M.; Mathison, David A.; Christiansen, Sandra C.; Simon, Ronald A.

doi:10.1016/s0091-6749(96)70123-9

Cited by 263 publications

(179 citation statements)

References 21 publications

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“…La necesidad de cirugía sinusal disminuyó de una cada tres años a una cada nueve años. Este estudio demostró el efecto benéfico a largo plazo de la desensibilización al ácido acetilsalicílico, en un período de seis años (14).…”

Section: Discussionunclassified

Alergia e intolerancia a antiinflamatorios no esteroides: desensibilización exitosa en tres casos y revisión de la literatura

et al. 2009

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Los antiinflamatorios no esteroides son la segunda causa de reacciones a medicamentos después de los beta-lactámicos. La prevalencia de las reacciones a antiinflamatorios no esteroideos en la población general es de 0,1% a 0,3% y la prevalencia de anafilaxia inducida por ellos es de 0,01%. La intolerancia al ácido acetilsalicílico o a los antiinflamatorios no esteroides se presenta con síntomas como urticaria aguda, angioedema, crisis asmática, enfermedad respiratoria exacerbada por ácido acetilsalicílico y anafilaxia. Presentamos una revisión actualizada basada en tres casos de pacientes con intolerancia al ácido acetilsalicílico o a los antiinflamatorios no esteroideos que, por sus enfermedades concomitantes, requerían tratamiento permanente conácido acetilsalicílico. Después de someterlos a un protocolo de desensibilización rápida ácido acetilsalicílico en una unidad de cuidados intensivos, estos pacientes pudieron continuar recibiendo ácido acetilsalicílico diariamente sin efectos adversos.Palabras clave: hipersensibilidad a los medicamentos, aspirina, agentes antiinflamatorios no esteroides, desensibilización inmunológica, asma, anafilaxis, pólipos nasales, sinusitis. Allergy and intolerance to nonsteroidal antinflammatory drugs: successful desensitization in three casesAdverse reactions to nonsteroidal antinflammatory drugs are the second cause of reactions to drugs after beta-lactams. Prevalence of these reactions among general population is between 0.1-0.3%, and prevalence of nonsteroidal antinflammatory drug-induced anaphylaxis is 0.01%. Acetylsalicylic acid or nonsteroidal antinflammatory drug sensitivity can be manifested as acute urticaria, angioedema, acute asthma, acetylsalicylic acid exacerbated respiratory disease and anaphylaxis.An updated review based on three cases of patientes with acetylsalicylic acid or nonsteroidal antinflammatory drug intolerance is presented in which, because of their concomitant diseases, permanent treatment with acetylsalicylic acid was required. After undergoing a fast acetylsalicylic acid desentization protocol in an intensive care unit, these patients were able to receive daily acetylsalicylic acid doses without any adverse effects.Key words: Drug hypersensitivity; aspirin; anti-inflammatory agents, non-steroidal; desensitization, immunologic; asthma, anaphylaxis, nasal polyps, sinusitis. Los antiinflamatorios no esteroides (AINE) son reconocidos entre los agentes terapéuticos más frecuentemente usados en todo el mundo, con un consumo estimado de 80 tabletas por persona al año. Debido a esta magnitud de exposición, no es sorprendente que los AINE sean una de

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Section: Discussionunclassified

Alergia e intolerancia a antiinflamatorios no esteroides: desensibilización exitosa en tres casos y revisión de la literatura

et al. 2009

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“…Many studies have shown that AD followed by daily aspirin treatment was associated with an improved clinical course in patients with AERD [8,[19][20][21][22][23][24][25][26][27][28][29][30][31][32] . A wide of aspirin dosages (100-1,300 mg/day) were used for the purpose of AD in these studies.…”

Section: Clinical Trials Of Admentioning

confidence: 99%

“…A wide of aspirin dosages (100-1,300 mg/day) were used for the purpose of AD in these studies. There was varying degree of clinical benefit obtained from AD in different studies; some showing benefit for only control of upper airway disease [8,[20][21][22] and some for both upper and lower airway disease [19,[23][24][25][26][27][28][29][30][31][32] . To our knowledge, in only one study, which was carried out on 10 aspirin sensitive asthma patients by using 500 mg aspirin, AD was found ineffective as measured as an improvement on pulmonary function tests and reduced need for systemic corticosteroids [33] .…”

Section: Clinical Trials Of Admentioning

confidence: 99%

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Aspirin Desensitization Treatment for the Management of Aspirin-Exacerbated Respiratory Disease

Cömert

Karakaya

Kalyoncu

2016

Journal of Respiratory Research

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Aspirin-exacerbated respiratory disease (AERD) is a clinical syndrome characterized by nasal polyps, chronic hypertrophic eosinophilic sinusitis, asthma, and sensitivity to cyclooxygenase-1 (COX-1) inhibitors. The treatment of asthma and chronic rhinosinusitis in AERD is difficult, since those patients usually suffer from severe steroid dependent asthma and frequent recurrence of nasal polyps despite combined medical and surgical treatment. Aspirin desensitization (AD) can be considered as an additional treatment option in selected patients with AERD. Aspirin doses ranging from 100 to 1,300 mg/day were reported to be effective for this purpose.

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“…22 Nasal polyps induced by aspirin have been shown to regress following endonasal desensitisation thus avoiding surgical removal. 23 The exact mechanism of desensitisation remains unclear.…”

Section: Aspirin Desensitisationmentioning

confidence: 99%

Aspirin sensitive asthma: current concepts

Bhatia

Katira²,

O’Reilly³

2002

Prim Care Respir J

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Aspirin desensitization treatment of aspirin-sensitive patients with rhinosinusitis-asthma: Long-term outcomes

Cited by 263 publications

References 21 publications

Alergia e intolerancia a antiinflamatorios no esteroides: desensibilización exitosa en tres casos y revisión de la literatura

Alergia e intolerancia a antiinflamatorios no esteroides: desensibilización exitosa en tres casos y revisión de la literatura

Aspirin Desensitization Treatment for the Management of Aspirin-Exacerbated Respiratory Disease

Aspirin sensitive asthma: current concepts

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