Aspirin-caffeine interaction in the rat

Collins, Catherine; Laird, R. I.; Richards, Pawel; Starmer, G. A.; Weyrauch, Solveig

doi:10.1111/j.2042-7158.1979.tb13602.x

Cited by 11 publications

(4 citation statements)

References 9 publications

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“…Traditionally, quantitative assessments of activity, exploration, and locomotor patterns have required the use of different testing chambers, such as the open field test, photobeam activity chambers, and holeboard tasks (Bushnell 1987; Collins et al 1979; Fink and Smith 1979; Fitzgerald et al 1988; Geyer et al 1986; Gold et al 1988; Gould et al 2001; Kulkarni and Dandiya 1975; Meliska and Loke 1984; Paulus and Geyer 1992; Sessions et al 1980). We developed the behavioral pattern monitor (BPM) for use in rats (Geyer et al 1986; Paulus and Geyer 1993) and mice (Risbrough et al 2006).…”

Section: Introductionmentioning

confidence: 99%

GBR 12909 administration as a mouse model of bipolar disorder mania: mimicking quantitative assessment of manic behavior

et al. 2009

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RationaleMania is a core feature of bipolar disorder (BD) that traditionally is assessed using rating scales. Studies using a new human behavioral pattern monitor (BPM) recently demonstrated that manic BD patients exhibit a specific profile of behavior that differs from schizophrenia and is characterized by increased motor activity, increased specific exploration, and perseverative locomotor patterns as assessed by spatial d.ObjectivesIt was hypothesized that disrupting dopaminergic homeostasis by inhibiting dopamine transporter (DAT) function would produce a BD mania-like phenotype in mice as assessed by the mouse BPM.MethodsWe compared the spontaneous locomotor and exploratory behavior of C57BL/6J mice treated with the catecholamine transporter inhibitor amphetamine or the selective DAT inhibitor GBR 12909 in the mouse BPM. We also assessed the duration of the effect of GBR 12909 by testing mice in the BPM for 3 h and its potential strain dependency by testing 129/SvJ mice.ResultsAmphetamine produced hyperactivity and increased perseverative patterns of locomotion as reflected in reduced spatial d values but reduced exploratory activity in contrast to the increased exploration observed in BD patients. GBR 12909 increased activity and reduced spatial d in combination with increased exploratory behavior, irrespective of inbred strain. These effects persisted for at least 3 h.ConclusionsThus, selectively inhibiting the DAT produced a long-lasting cross-strain behavioral profile in mice that was consistent with that observed in manic BD patients. These findings support the use of selective DAT inhibition in animal models of the impaired dopaminergic homeostasis putatively involved in the pathophysiology of BD mania.

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Section: Introductionmentioning

confidence: 99%

GBR 12909 administration as a mouse model of bipolar disorder mania: mimicking quantitative assessment of manic behavior

et al. 2009

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“…These advantages are most clearly demonstrated in research assessing the effects of stimulant drugs on rodents. Depending upon dose, drugs such as amphetamine, apomorphine, caffeine, 3-4-methylenedioxymethamphetamine (MDMA), nicotine, phencyclidine and scopolamine all induce similar increases in the amount of activity, as measured in the Open Field, photobeam activity chambers, or the BPM (Bushnell 1987,Collins et al 1979,Fink and Smith 1979,Fitzgerald et al 1988,Geyer et al 1986,Gold et al 1988,Gould et al 2001, Krebs-Thompson et al 1998, Kulkarni and Dandiya 1975,Meliska and Loke 1984,Paulus and Geyer 1992,Sessions et al 1980. Some differential effects have been noted however, when even the simplest of multivariate assessments is used (see Table 1 for summary).…”

Section: Assessing Multivariate Behavioral Profilesmentioning

confidence: 99%

“…Some differential effects have been noted however, when even the simplest of multivariate assessments is used (see Table 1 for summary). For example, while caffeine also increased rearing behavior in the Open Field and BPM, as well as holepoking in the holeboard and BPM (Collins et al 1979,Geyer et al 1986,Meliska and Loke 1984,Rao et al 1999, nicotine had no effect on rearing behavior in the Open Field or BPM (Geyer et al 1986,Meliska andLoke 1984). In fact, higher doses of nicotine reduced the amounts of locomotion and holepoking behavior (Marco et al 2005,Marks et al 1986), likely due to hypothermic effects.…”

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confidence: 99%

A reverse-translational approach to bipolar disorder: Rodent and human studies in the Behavioral Pattern Monitor

Young

Minassian

Paulus

et al. 2007

Neuroscience & Biobehavioral Reviews

106

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Mania is the defining feature of Bipolar Disorder (BD). There has been limited progress in understanding the neurobiological underpinnings of BD mania and developing novel therapeutics, in part due to a paucity of relevant animal models with translational potential. Hyperactivity is a cardinal symptom of mania, traditionally measured in humans using observer-rated scales. Multivariate assessment of unconditioned locomotor behavior using the rat Behavioral Pattern Monitor (BPM) developed in our laboratory has shown that hyperactivity includes complex multifaceted behaviors. The BPM has been used to demonstrate differential effects of drugs on locomotor activity and exploratory behavior in rats. Studies of genetically engineered mice in a mouse BPM have confirmed its utility as a cross-species tool. In a "reverse-translational" approach to this work, we developed the human BPM to characterize motor activity in BD patients. Increased activity, object interactions, and altered locomotor patterns provide multidimensional phenotypes to model in the rodent BPM. This unique approach to modeling BD provides an opportunity to identify the neurobiology underlying BD mania and test novel antimanic agents. KeywordsBipolar Disorder; mania; locomotor activity; exploratory; rat; mouse; Behavioral Pattern Monitor; Open Field; hyperactivity Modeling BD maniaBipolar disorder (BD) is a severe psychiatric disorder that affects approximately 2-7% of the general population (Friedman et al. 2006). Mania is the defining feature of BD although patients can also manifest depressive symptoms. During the manic episodes of BD, patients exhibit impulsive behavior, hypersexuality, pressured speech, flight of ideas, and motor hyperactivity, which have been conceptualized as inhibitory failures of behavior and thought (Goodwin and Jamison 1990). These symptoms profoundly impair and disrupt social, occupational, and family life in individuals with BD (Post et al. 2003). Despite the prevalence of this disorder, surprisingly few studies (Franks et al. 1983,Gooding and Tallent 2001,Murphy et al. 1999, have attempted to develop adequate translational models to elucidate the neurobiology * Correspondence should be sent to: Martin P. Paulus, M.D. Department of Psychiatry, UCSD, La Jolla, California, 92093-9116 Phone: (858) Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. NIH Public Access Author ManuscriptNeurosci Biobehav Rev. Author manuscript; available in PMC 2008 January 1. Published in final edited form as:Neurosci Biobehav Rev. 2007 ; 31(6): 882-896. NIH-PA Author ManuscriptNIH-PA Author Manu...

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“…Caffeine co-administration with aspirin was noticed to cause long-lasting hyperactivity [115]. Combining caffeine (10 mg/kg) with a low amount of alcohol (‘caffeinol’ [116]) appears to reduce the cortical infarct volume and improves recovery following stroke.…”

Section: “Repurposing” Of Caffeinementioning

confidence: 99%

Winning a Won Game: Caffeine Panacea for Obesity Syndemic

Myslobodsky

Eldan²

2010

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Over the past decades, chronic sleep reduction and a concurrent development of obesity have been recognized as a common problem in the industrialized world. Among its numerous untoward effects, there is a possibility that insomnia is also a major contributor to obesity. This attribution poses a problem for caffeine, an inexpensive, “natural” agent that is purported to improve a number of conditions and is often indicated in a long-term pharmacotherapy in the context of weight management. The present study used the “common target” approach by exploring the tentative shared molecular networks of insomnia and adiposity. It discusses caffeine targets beyond those associated with adenosine signaling machinery, phosphodiesterases, and calcium release channels. Here, we provide a view suggesting that caffeine could exert some of its effects by acting on several signaling complexes composed of HIF-1α/VEGF/IL-8 along with NO, TNF-α, IL1, and GHRH, among others. Although the relevance of these targets to the reported therapeutic effects of caffeine has remained difficult to assess, the utilization of caffeine efficacies and potencies recommend its repurposing for development of novel therapeutic approaches. Among indications mentioned, are neuroprotective, nootropic, antioxidant, proliferative, anti-fibrotic, and anti-angiogenic that appear under a variety of dissimilar diagnostic labels comorbid with obesity. In the absence of safe and efficacious antiobesity agents, caffeine remains an attractive adjuvant.

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Aspirin-caffeine interaction in the rat

Cited by 11 publications

References 9 publications

GBR 12909 administration as a mouse model of bipolar disorder mania: mimicking quantitative assessment of manic behavior

GBR 12909 administration as a mouse model of bipolar disorder mania: mimicking quantitative assessment of manic behavior

A reverse-translational approach to bipolar disorder: Rodent and human studies in the Behavioral Pattern Monitor

Winning a Won Game: Caffeine Panacea for Obesity Syndemic

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