Aspirin and subtypes of asthma: Risk factor analysis

Falliers, Constantine J.

doi:10.1016/0091-6749(73)90030-4

Cited by 67 publications

(21 citation statements)

References 11 publications

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“…Similarly, Chaffe & Settipane observed positive skin tests in 65% of aspirin-intolerant asthmatics; 51% of the subjects had atopic diseases in their families (20). On the contrary, Falliers believed that asthmatic patients sensitive to aspirin were not atopic, and that a negative correlation between aspirin-intolerance and atopy traits existed (21 ).…”

Section: Discussionmentioning

confidence: 99%

The atopy trait in hypersensitivity to nonsteroidal anti‐inflammatory drugs

Bochenek

Nizankowska

Szczeklik

1996

Allergy

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The prevalence of atopy was evaluated in two groups of subjects with hypersensitivity to nonsteroidal anti‐inflammatory drugs (NSAID): 78 patients with aspirin‐induced asthma (AIA) confirmed by oral or bronchial provocation challenges 42 subjects with hypersensitivity to pyrazolone drugs (case history and positive skin tests to noramidopyrine/aminophenazone) who tolerated aspirin well. Fifty sex‐ and age‐matched persons from an unselected general population, with no hypersensitivity to NSAID, formed the control group. Atopy was estimated from the results of the following clinical and biologic parameters: 1) personal and family history of atopic diseases 2) skin prick tests with 16 aeroallergens 3) serum levels of specific IgE to five aeroallergens 4) total serum IgE level. Different definitions of atopy were used, consisting of constellations of two or three of the above‐mentioned features. The results of the study revealed that the prevalence of atopy varied according to the criteria used for its definition. Irrespective of the definition used, a similar distribution of atopy was observed in both groups of patients with hypersensitivity to NSAID. Atopy was more frequent in either group of patients with intolerance of NSAID than in the control group. Thus, atopy is related to adverse drug reactions to NSAID.

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Section: Discussionmentioning

confidence: 99%

The atopy trait in hypersensitivity to nonsteroidal anti‐inflammatory drugs

Bochenek

Nizankowska

Szczeklik

1996

Allergy

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“…Thus the sensitivity of P-receptors to isoproterenol is reduced in older rats (Ericsson, 1974). The incidence of aspirin intolerance is higher in middle-aged than in young asthmatics (Pearsons, 1963;Samter & Beers, 1968;Farr, 1970;Falliers, 1973;Von Maur et al, 1974). The slightly decreased intensity of reactions to aspirin of older guinea-pigs (12-16 weeks) as compared to guinea-pigs of 8-10 weeks, may correspond to the decline in aspirin intolerance in patients past middle age (Pearsons, 1963).…”

Section: Discussionmentioning

confidence: 99%

Dual Effects of Aspirin in Guinea‐pig Lungs

Mielens

Rosenberg

1976

British J Pharmacology

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Dual effects of aspirin were demonstrated in guinea‐pig lungs: (a) aspirin (3.3 mg/kg i.v.) antagonized bronchoconstriction induced by slow reacting substance of anaphylaxis (SRS‐A); (b) aspirin produced bronchoconstriction when injected in the presence of propranolol into guinea‐pigs in vivo at 330 mg/kg, or into guinea‐pig isolated lungs in vitro as a 4% solution (40 mg/ml). The severity of bronchoconstriction following administration of aspirin was directly related to the degree of β‐adrenoceptor blockade and to the age of the guinea‐pigs. Aspirin‐induced bronchoconstriction was prevented in vivo and in vitro by atropine and it could be reversed in vivo by atropine. Aspirin‐induced bronchoconstriction was not inhibited by vagotomy or phenoxybenzamine. These data suggest that the mechanism involved in aspirin‐induced bronchoconstriction may be local cholinergic stimulation and that reduced β‐adrenergic drive may be a predisposing factor.

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“…Giraldo et al [11] found a 3% prevalence of ASA intol erance in 75 patients using anamnestic data. Falliers [1] found a prevalence of aspirin intolerance of 1.9% in a cohort of 1,298 children using clinical history, but adverse reactions other than bronchial asthma were also considered (urticaria, angioedema and hypotension). Chaffe and Settpane [2], using anamnestic crite ria, observed that 3.1% of their asthmatics had bronchospastic reactions provoked by ASA.…”

Section: Discussionmentioning

confidence: 99%

“…Estimates of the prevalence of ASA intolerance have been made on the basis of clinical histories [1][2][3] or using oral challenges [4][5][6][7][8][9]. Reports of adverse reactions to ASA differ widely with re spect to the prevalence of this pheno menon.…”

Section: Introductionmentioning

confidence: 99%