Aspirin and statin use and the subsequent development of depression in men and women: Results from a longitudinal population-based study

Abstract

Our data do not support a large scale preventive treatment of depression using aspirin or statins in subjects aged from 35 to 66 years from the community.

Aspirin and incident depressive symptoms: A longitudinal cohort study over 8 years

“…Our findings are in general agreement with those present in the literature, in which depressive symptoms do not appear to benefit from aspirin use. All studies, except one, reported that the use of aspirin was not associated with any favorable effect on depression. In comparison with these previous studies, the strength of our study includes the use of propensity score matching to further control for background sociodemographic variables.…”

“…The literature regarding the possible impact of aspirin on depression is limited and unclear. Two observational studies did not find any significant association between the use of aspirin and the development of depression . An open‐label trial found that aspirin did not provide any benefit as a treatment for a current major depressive episode and was associated with several side effects when added to citalopram in 10 subjects with a diagnosis of MDD .…”

“…Two observational studies did not find any significant association between the use of aspirin and the development of depression. 14,15 An open-label trial found that aspirin did not provide any benefit as a treatment for a current major depressive episode and was associated with several side effects when added to citalopram in 10 subjects with a diagnosis of MDD. 16 Conversely, another interventional study reported that aspirin is beneficial when added to selective reuptake inhibitors in patients with MDD who had failed to respond to an antidepressant trial.…”

Inflammation and the Silent Sequelae of Stroke

“…And in experimental models, SSRIs attenuate lipopolysaccharide-induced inflammation [91]. A variety of more traditional antiinflammatory therapies has also been used for the treatment of depression, including aspirin and other nonsteroidal antiinflammatory drugs, statins, and cytokine inhibitors like etanercept (which blocks TNF) [92][93][94][95]. Agomelatine is a a b c d member of a novel class of new antidepressants which are melatonin agonists; it has been approved by the European Union, after being shown to have similar efficacy to SSRIs for the treatment of depression [96,97].…”

A case of erectile dysfunction induced by red yeast rice in lipid‐lowering therapy

“…Some studies think that statins can inhibit cholesterol synthesis and further inhibit testosterone production, which may be one of the causes of ED (Corona, Boddi, Balercia, et al, ). The lipid solubility of statins affects the central nervous system and induces penis peripheral nerves dysfunction, which may be one of the causes of ED (Glaus, Vandeleur, Lasserre, et al, ). Previous studies had reported statins can induce depression (Monika, Fritz, Gunther, et al, ).…”