Aspirin alleviates skin inflammation and angiogenesis in rosacea

Deng, Zhili; Xu, San; Peng, Qinqin; Sha, Ke; Xiao, Wenqin; Liu, Tangxiele; Zhang, Yiya; Wang, Ben; Xie, Hongfu; Chen, Mengting; Li, Ji

doi:10.1016/j.intimp.2021.107558

Cited by 8 publications

(7 citation statements)

References 45 publications

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“…One of our previous works confirmed the upregulation of Th1 (CXCL10), Th17 (CCL20, IL17A), neutrophils (CXCL2), and macrophages (CCL2) associated with chemokines and cytokines in rosacea‐like mouse skin 18 . Another work of our group also revealed the enrichment of chemokine signaling pathway by RNA sequencing and found that the mRNA expression of Ccl3, Ccl5, Ccl20, Cxcl10, Cxcl11, and Cxcl12 were significantly elevated in skin lesions of rosacea‐like mouse 19 . Consistently, further RNA sequencing of rosacea patient skin also showed enrichment of chemokine signaling pathway and the upregulation of many chemokines and cytokines including CCL2, CCL3, CCL5, CCL20, CXCL8, CXCL9, CXCL10, and CXCL11 20 .…”

Section: Introductionsupporting

confidence: 77%

Increased serum levels of CCL3, CXCL8, CXCL9, and CXCL10 in rosacea patients and their correlation with disease severity

Liu

Deng

et al. 2022

The Journal of Dermatology

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Rosacea is a common chronic inflammatory skin disease involving millions of patients worldwide. Previous studies have highlighted the upregulation of a variety of chemokines in the skin lesions of both rosacea patient and rosacea‐like mouse model. However, the serum levels of these chemokines and their clinical significance have not been explored before. In this study, we aimed at examining the serum levels of a series of chemokines (including CCL2, CCL3, CCL20, CXCL1, CXCL8, CXCL9, CXCL10, and CXCL12) implicated in rosacea and their correlation with disease severity. Bio‐Plex Pro Human Chemokine Assays were used to measure the serum levels of these chemokines. Investigator’s Global Assessment (IGA) was applied for assessing the papules/pustules of rosacea patients, while persistent erythema was evaluated by the Clinician’s Erythema Assessment (CEA). Our results revealed that the serum concentration of CCL3, CXCL8, CXCL9, and CXCL10 were markedly elevated in rosacea patients compared to healthy controls. Among them, the levels of CCL3, CXCL8, and CXCL9 were positively correlated with the IGA score, while serum CXCL9 and CXCL10 were positively related with the CEA score of rosacea patients. What’s more, the expression of the corresponding receptors of CCL3 (Ccr1), CXCL8 (Cxcr1 and Cxcr2), CXCL9, and CXCL10 (Cxcr3) were all significantly increased in the skin lesions of rosacea‐like mouse model with CXCR2 and CXCR3 highly expressed in rosacea patient skins. Our results indicated that CCL3, CXCL8, CXCL9, and CXCL10 might potentially serve as serum indicators for rosacea and could assist the severity evaluation of disease. Findings in this study would also potentially help to develop new targeted therapies for rosacea in future. © 2022 Japanese Dermatological Association

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Section: Introductionsupporting

confidence: 77%

Increased serum levels of CCL3, CXCL8, CXCL9, and CXCL10 in rosacea patients and their correlation with disease severity

Liu

Deng

et al. 2022

The Journal of Dermatology

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“…Artemisinin, an antimalarial drug from Artemisia annua L, exhibits anti-inflammatory and anti-angiogenic properties, and ameliorates rosacea-like dermatitis [ 101 ]. A recent study on mice found that aspirin reduces microvessel density and VEGF expression in rosacea-like skin, and also activation of NF-κB signaling and the release of downstream pro-inflammatory cytokines [ 102 ]. Tranexamic acid, an antifibrinolytic agent recently used to treat melasma in Asian patients, improves rosacea by reducing IL-6, TNFα, and MMP expression, and also lowers the angiogenesis of rosacea by reducing VEGF expression and the number of CD31+ cells [ 103 ].…”

Section: Rosaceamentioning

confidence: 99%

Angiogenesis in Chronic Inflammatory Skin Disorders

Lee

Hong

Kim

2021

IJMS

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Angiogenesis, the growth of new blood vessels from preexisting vessels, is associated with inflammation in various pathological conditions. Well-known angiogenetic factors include vascular endothelial growth factor (VEGF), angiopoietins, platelet-derived growth factor, transforming growth factor-β, and basic fibroblast growth factor. Yes-associated protein 1 (YAP) and transcriptional co-activator with PDZ-binding motif (TAZ) have recently been added to an important angiogenic factor. Accumulating evidence indicates associations between angiogenesis and chronic inflammatory skin diseases. Angiogenesis is deeply involved in the pathogenesis of psoriasis. VEGF, angiopoietins, tumor necrosis factor-a, interleukin-8, and interleukin-17 are unregulated in psoriasis and induce angiogenesis. Angiogenesis may be involved in the pathogenesis of atopic dermatitis, and in particular, mast cells are a major source of VEGF expression. Angiogenesis is an essential process in rosacea, which is induced by LL-37 from a signal cascade by microorganisms, VEGF, and MMP-3 from mast cells. In addition, angiogenesis by increased VEGF has been reported in chronic urticaria and hidradenitis suppurativa. The finding that VEGF is expressed in inflammatory skin lesions indicates that inhibition of angiogenesis is a useful strategy for treatment of chronic, inflammatory skin disorders.

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“…Although the recent consensus guidelines for rosacea only recommend beta-blockers, doxycycline, and isotretinoin as systemic treatment modalities for rosacea [ 7 ], antihistamines and NSAIDs were frequently prescribed in real-world settings. Indeed, NSAIDs can attenuate the skin inflammation and angiogenesis in rosacea [ 22 ]. We suggest that this is probably due to their anti-inflammatory effect, and their ability to reduce the skin symptoms (i.e., pain and itch) that rosacea patients often complain of; therefore, antihistamines and NSAIDs are commonly prescribed for rosacea by dermatologists.…”

Section: Discussionmentioning

confidence: 99%

Patient Visits and Prescribing Patterns Associated with Rosacea in Korea: A Real-World Retrospective Study Based on Electronic Medical Records

Woo

Bae³

et al. 2022

JCM

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Rosacea is a common and chronic inflammatory skin disorder. The visiting trends and prescribing patterns involving Korean patients with rosacea have not been thoroughly examined. To examine the visiting trends of patients with rosacea, and to analyze the prescription patterns of Korean dermatologists managing such patients, a retrospective cross-sectional study on dermatology outpatients who visited the seven affiliated hospitals of The Catholic University of Korea between 2007 and 2018 was performed. A total of 56,651 visits were made by rosacea patients. The mean annual number of hospital visits made by rosacea patients over a 6-year period increased from 2456 in 2007–2012 to 6985 in 2013–2018. Hospital visits were most prevalent in female patients aged 40 to 59 years. There was no statistically significant difference in patient visitation between the seasons. As for prescriptions, systemic antibiotics were most commonly prescribed, followed by antihistamines, non-steroidal anti-inflammatory drugs, and retinoids. Among the topical agents, metronidazole was the most prescribed agent during 2007–2012, whereas calcineurin inhibitors were favored most during 2013–2018. Dermatology outpatient visits by individuals with rosacea have increased in Korea over time. The real-world prescription trend presented here may help dermatologists facilitate better treatment strategies and provide appropriate guidance to patients with rosacea.

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Aspirin alleviates skin inflammation and angiogenesis in rosacea

Cited by 8 publications

References 45 publications

Increased serum levels of CCL3, CXCL8, CXCL9, and CXCL10 in rosacea patients and their correlation with disease severity

Increased serum levels of CCL3, CXCL8, CXCL9, and CXCL10 in rosacea patients and their correlation with disease severity

Angiogenesis in Chronic Inflammatory Skin Disorders

Patient Visits and Prescribing Patterns Associated with Rosacea in Korea: A Real-World Retrospective Study Based on Electronic Medical Records

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