Aspirin acts in esophageal cancer: a brief review

Hao, Weiming; Shen, Yaxing; Feng, Mingxiang; Lin, Miao; Fang, Yong; Tan, Lijie

doi:10.21037/jtd.2018.03.110

Cited by 15 publications

(12 citation statements)

References 63 publications

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“…Aspirin is a salicylic acid drug widely used for anti-inflammatory, analgesia and the prevention and treatment of cardiovascular disease [102]. In recent years, mounting studies have revealed that aspirin can inhibit many malignant tumors such as hepatobiliary and colorectal carcinoma [82].…”

Section: Aspirinmentioning

confidence: 99%

The Multiple Roles of Glucose-6-Phosphate Dehydrogenase in Tumorigenesis and Cancer Chemoresistance

Song

Sun

Zhang

et al. 2022

Life

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The pentose phosphate pathway (PPP) is a branch from glycolysis that begins from glucose-6-phosphate (G6P) and ends up with fructose-6-phosphate (F6P) and glyceraldehyde-3-phosphate (GADP). Its primary physiological significance is to provide nicotinamide adenine dinucleotide phosphate (NADPH) and nucleotides for vital activities such as reactive oxygen species (ROS) defense and DNA synthesis. Glucose-6-phosphate dehydrogenase (G6PD) is a housekeeping protein with 514 amino acids that is also the rate-limiting enzyme of PPP, catalyzing G6P into 6-phosphogluconolactone (6PGL) and producing the first NADPH of this pathway. Increasing evidence indicates that G6PD is upregulated in diverse cancers, and this dysfunction influences DNA synthesis, DNA repair, cell cycle regulation and redox homeostasis, which provides advantageous conditions for cancer cell growth, epithelial-mesenchymal transition (EMT), invasion, metastasis and chemoresistance. Thus, targeting G6PD by inhibitors has been shown as a promising strategy in treating cancer and reversing chemotherapeutic resistance. In this review, we will summarize the existing knowledge concerning G6PD and discuss its role, regulation and inhibitors in cancer development and chemotherapy resistance.

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Section: Aspirinmentioning

confidence: 99%

The Multiple Roles of Glucose-6-Phosphate Dehydrogenase in Tumorigenesis and Cancer Chemoresistance

Song

Sun

Zhang

et al. 2022

Life

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“…Aspirin, the most used nonsteroidal anti-inflammatory medication, exerts its antipyretic, analgesic, and antiinflammatory actions by blocking prostaglandin synthesis [2]. As contemporary medicine has progressed, there is clinical evidence that aspirin can prevent colorectal, endometrial, ovarian, pancreatic, gallbladder, ureteral, gastric, and kidney cancers, as well as lower the incidence and spread of fibrosarcoma and prostate cancer [3][4][5][6][7][8][9]. However, longterm aspirin use can result in stomach ulcers, stomach bleeding, kidney failure, and other adverse effects [6,10].…”

Section: Introductionmentioning

confidence: 99%

Anticancer and Anti-Inflammatory Mechanisms of NOSH-Aspirin and Its Biological Effects

Zhou

Zeng

et al. 2022

Computational and Mathematical Methods in Medicine

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NOSH-Aspirin, which is generated from NO, H2S, and aspirin, affects a variety of essential pathophysiological processes, including anti-inflammatory, analgesic, antipyretic, antiplatelet, and anticancer properties. Although many people acknowledge the biological significance of NOSH-Aspirin and its therapeutic effects, the mechanism of action of NOSH-Aspirin and its regulation of tissue levels remains obscure. This is in part due to its chemical and physical features, which make processing and analysis difficult. This review focuses on the biological effects of NOSH-Aspirin and provides a comprehensive analysis to elucidate the mechanism underlying its disease-protective benefits.

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“…Today, approximately 90% of all Esophageal adenocarcinoma in the United States are EACs, and EACs that develop from BE have increased six-fold over the past 30 years [18]. Anti-inflammatory drugs such as aspirin have been found to reduce chronic inflammation and thus reduce the probability of BE developing EAC, suggesting that inflammation is one of the causes of EAC [19].…”

Section: Barrett's Esophagusmentioning

confidence: 99%

Research Progress in Relationship between Chronic Inflammation and Development of Esophageal Cancer

2022

IJFM

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As a common malignant tumor of the digestive tract, esophageal cancer has a high incidence in China, accounting for about half of the global incidence. The pathogenic factors are complicated, primarily related to eating diet, obesity, gastroesophageal reflux disease, and Barrett's esophagus. In this article, through the literature search of Web of Science, PubMed, and CNKI, we analyzed the transformation of inflammatory cells cytokines. We activated the inflammatory pathway in chronic inflammation of the esophagus. These form the tumor microenvironment suitable for tumorigenesis, proliferation, and metastasis, essential in transforming inflammation, metaplasia, and adenocarcinoma of the esophagus. Therefore, understanding the relationship between chronic inflammation and esophageal cancer development can provide new ideas for preventing and treating esophageal cancer.

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Aspirin acts in esophageal cancer: a brief review

Cited by 15 publications

References 63 publications

The Multiple Roles of Glucose-6-Phosphate Dehydrogenase in Tumorigenesis and Cancer Chemoresistance

The Multiple Roles of Glucose-6-Phosphate Dehydrogenase in Tumorigenesis and Cancer Chemoresistance

Anticancer and Anti-Inflammatory Mechanisms of NOSH-Aspirin and Its Biological Effects

Research Progress in Relationship between Chronic Inflammation and Development of Esophageal Cancer

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