Aspirin (acetylsalicylic acid) intoxication, a proposed new method of treatment

Doolan, Paul D.; Walsh, William P.; Kyle, Laurence H.; Wishinsky, Henry

doi:10.1016/0002-9343(51)90069-1

Cited by 14 publications

(15 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The patient was treated with the usual methods including massive intravenous fluid therapy but (12). Merrill has reported the use of the artificial kidney in the therapy of bromide poisoning (13) and has commented on its application to barbiturate intoxication (14 The results obtained make it appear that certain advantages might be obtained by hemodialysis in some patients with lesser degrees of barbiturate poisoning soon after the ingestion of the drug.…”

Section: Resultsmentioning

confidence: 99%

The Application of Hemodialysis to the Treatment of Barbiturate Poisoning 1

Kyle¹,

Jeghers²,

Walsh³

et al. 1953

J. Clin. Invest.

Self Cite

View full text Add to dashboard Cite

Section: Resultsmentioning

confidence: 99%

The Application of Hemodialysis to the Treatment of Barbiturate Poisoning 1

Kyle¹,

Jeghers²,

Walsh³

et al. 1953

J. Clin. Invest.

Self Cite

View full text Add to dashboard Cite

“…In overdose, the extent of protein binding decreases considerably, making it an ideal poison for extracorporeal removal with IHD [7,8]. Indications for dialysis include altered mental status, new hypoxemia, a salicylate concentration >7.2 mmol/L (100 mg/dL) in cases of acute poisoning, or lower concentration in cases of chronic poisoning, or with renal impairment [9].…”

Section: Discussionmentioning

confidence: 99%

Modern Intermittent Haemodialysis (IHD) is an Effective Method of Removing Salicylate in Chronic Topical Salicylate Toxicity

et al. 2015

View full text Add to dashboard Cite

Introduction There are limited data on modern intermittent hemodialysis (IHD) efficacy on salicylate elimination from topical poisoning. Case report A 54-year-old male sought treatment for dyspnea but was then diagnosed with salicylate toxicity from topical application of Dencorub Extra Strength Heat Gel® for 1 week. Each tube contained 100 g with 26 % methylsalicylate (26 g). Laboratory workup was remarkable for an elevated anion gap of 30 and salicylate concentration of 78.7 mg/dL [5.7 mmol/L (N<0.4 mmol/L)]. Treatment with urinary alkalinization was followed by hemodialysis for 5 h. Extraction ratios were 0.44 with clearance rates of 78.5 mL/min. Salicylate concentrations fell rapidly following initiation of hemodialysis with no rebound observed. Discussion Modern high flux IHD is an effective method of removing salicylates in the treatment of chronic topical poisoning.

show abstract

“…By the early 1950s Kyle and colleagues investigated whether dialysis was useful in treating patients with barbiturate overdoses since a relatively small amount of the ingested barbiturate dose was felt to be protein bound and thus inaccessible to removal by dialysis [11]. They used dialysis to treat salicylate overdose, suggesting that early treatment may lead to almost complete recovery of total ingested salicylate load [12].…”

Section: Cellophanementioning

confidence: 99%