Aspiration of Solid Food Particles Into Lungs of Patients with Gastroesophageal Reflux and Chronic Bronchial Disease

Omeprazole reduces the response to capsaicin but not to methacholine in asthmatic patients with proximal reflux

“…This result might suggest a role for acid microaspiration into the airways [53], in line with previous findings of gastro-hypopharyngeal reflux in chronic cough [47]. However, this theory is in contrast to the results of studies using radioisotope techniques which failed to show aspiration in most patients [54,55] and with the fact that perfusion of the distal esophagus with acid precipitates cough [48]. An explanation for our results may be that the severity of reflux-induced cough is better related to the surface of the exposed esophagus (maximal when acid reaches the proximal portion) than to the percentage of time during which refluxate floods the distal esophagus.…”

Airway reactivity following repeated milk aspiration in rabbits

“…tric contents causing bronchospasm by stimulation of upper airway receptors or bronchitis. 8,9 Several causes of acute airway injury have been found to be associated with bronchial hyperresponsiveness. Among these are ozone, 10,11 active or passive cigarette smoking, 12,13 industrial and occupational pollutants, 14 and air pollution.…”

Values and Limitations of Pharyngolaryngoscopy (Transnasal, Transoral) in Patients with Dysphagia

“…One may raise the objection that, according to the literature, nearly 50% of healthy adults aspirate small amounts of saliva during sleep [39], which might raise the question of the clinical relevance of our observation. However, 4 out of 7 patients with endoscopic verification of salivary aspiration and nonremarkable VFS outcome had severe pulmonary complications such as chronic bronchitis or pneumonia.…”

“…Von verschiedenen Autoren wird die grosse Sensitivität und Spezifität der Methode in der Erfassung der wichtigsten Zeichen einer Schluckstörung beschrieben: Retentionen, Penetration und Aspiration. In unserer Studie über 39 Patienten mit neurogener Dysphagie fanden wir ebenfalls eine hohe Übereinstimmung zwischen den Ergebnissen der videoendoskopischen und videofluo- roskopischen Untersuchung hinsichtlich des kritischsten Symptoms, der Aspiration. Darüberhinaus konnten durch die endoskopische Untersuchung Patienten erfasst werden, welche ihren Speichel aspirierten, in der radiologischen Untersuchung jedoch unauffällig waren.…”