Aspiration Cytology in the Preoperative Management of Breast Cancer

Improved Breast Cytology Results with Near Patient FNA Diagnosis

“…The results of the present study are comparable to those other series, 4,6,[12][13][14][15][16][17][18][19][20][21][22] in which specificity ranged from 44% to 90%, absolute sensitivity from 30% to 91% and complete sensitivity from 66% to 99%. Because most non-NPFD specimens were reported by general pathologists, the significantly improved specificity from discrete breast lumps with NPFD in the present series could be explained by improved FNA sample acquisition, improved cyto- logic reporting by the cytopathologist or both.…”

“…Whether this lower unsatisfactory rate was the result of the skill (better at performing FNA) or of the technique (repeating unsatisfactory FNAs to obtain sufficient material prior to issuing a report) of the cytopathologist performing NPFD could not be determined from our data. Breast FNA unsatisfactory rates are influenced by patient factors-age, 18 lesion size, 2,18,21 lesion palpability (discrete lump or thickening), 6,7,10,15,20,23 benign or malignant histology, 6,18,20 and histologic type 2,21,24 -and operator factors. 3,4,16,18,25,26 Palombini et al noted better results from series in which the cytopathologist who interpreted the smears also performed the FNA.…”

Fine Needle Aspiration Cytology of Palpable Breast Lump: A Study of 1778 Cases

“…95% accuracy in preoperative diagnosis of mammary cancer by clinicocytological combination was reported in a study [5]. As FNAC became more reliable in diagnosing malignancy and thereby the use of frozensection histology had been reduced by about 80 % [6]. The present study is intended to look the frequency distribution of different lesions in FNAC of palpable breast lumps.…”

Punção Aspirativa por Agulha Fina Orientada por Ultra-Sonografia em Lesões Não-palpáveis

“…Esta variação dos resultados pode ser decorrente da inexperiência do citologista, da baixa celularidade ou da diferenciação histológica da lesão 20 . Os achados falso-negativos podem ocorrer em 10% dos casos e geralmente decorrem de material insuficiente para análise, principalmente em nódulos pequenos ou lesões com alto grau de diferenciação 16,17,21 . Já os resultados falso-positivos são raros (em torno de 1,6%) 22 , incidindo geralmente em casos em que existe regeneração celular com aumento do volume dos núcleos e nucléolos.…”