Aspidsaponins A–D, Four new steroidal saponins from the rhizomes of Aspidistra elatior Blume and their cytotoxicity

Zuo, Sheng-Qi; Liu, Yingnan; Yang, Yang; Liu, Cheng‐Xiong; Guo, Zhiyong; He, Hui; Tu, Xuan; Zou, Kun

doi:10.1016/j.phytol.2018.04.017

Cited by 13 publications

(7 citation statements)

References 18 publications

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“…Therapeutic approaches, therefore, remain a challenge for anticancer drug discovery. Natural compounds from the plant genus Aspidistra have been shown to possess anticancer properties because they contain up to one hundred types of biologically active saponins [22][23][24]. These properties are mainly attributed to the presence of polysaccharides and their derivatives [30,31].…”

Section: Discussionmentioning

confidence: 99%

“…Aspidistra contains rich chemical components, including saponins, lectins, and homoisoflavones. Additionally, this genus is a potential source of secondary metabolites with a broad spectrum of biological activities, including antifungal [ 19 ], antitumor [ 20 ], antibacterial [ 21 ] and cytotoxic activities [ 22 – 24 ]. Previously, phytochemical investigations of active steroidal saponins led to their isolation and characterization, and aspiletrein A (AA) (Fig.…”

Section: Introductionmentioning

confidence: 99%

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Antitumor activities of Aspiletrein A, a steroidal saponin from Aspidistra letreae, on non-small cell lung cancer cells

Nguyen

Seephan

et al. 2021

BMC Complement Med Ther

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Background Lung cancer is one of the leading causes of death worldwide due to its strong proliferative and metastatic capabilities. The suppression of these aggressive behaviors is of interest in anticancer drug research and discovery. In recent years, many plants have been explored in order to discover new bioactive secondary metabolites to treat cancers or enhance treatment efficiency. Aspiletrein A (AA) is a steroidal saponin isolated from the whole endemic species Aspidistra letreae in Vietnam. Previously, elucidation of the structure of AA and screening of its cytotoxic activity against several cancer cell lines were reported. However, the antitumor activities and mechanisms of action have not yet been elucidated. In this study, we demonstrated the anti-proliferative, anti-migrative and anti-invasive effects of AA on H460, H23 and A549 human lung cancer cells. Methods MTT, wound healing and Transwell invasion assays were used to evaluate the anti-proliferation, anti-migration and anti-invasion effects of AA, respectively. Moreover, the inhibitory effect of AA on the activity of protein kinase B (Akt), a central mediator of cancer properties, and apoptotic regulators in the Bcl-2 family proteins were investigated by Western blotting. Results AA exhibits antimetastatic effects in human lung cancer cells through the inhibition of the pAkt/Akt signaling pathway, which in turn resulted in a significant inhibitory effect of AA on the migration and invasion of the examined lung cancer cells. Conclusions Aspiletrein A may be a potent inhibitor of protein kinase B (Akt). Hence, AA could be further explored as a potential antimetastatic lead compound.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Antitumor activities of Aspiletrein A, a steroidal saponin from Aspidistra letreae, on non-small cell lung cancer cells

Nguyen

Seephan

et al. 2021

BMC Complement Med Ther

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“…Last but not least, in recent years Aspidistra species have become of increasing pharmacological interest since it turned out that they contain a number of steroidal saponins, showing diverse physiological effects, which are of great interest in human medicine (Mori and Kawasaki 1973, Hirai et al 1982, Konishi 1984, Koketsu et al 1996, Cui et al 2013, 2016, Xu et al 2015, Liang et al 2016, Peng et al 2017, Zuo et al 2018, Ho et al 2020).…”

Section: Introductionmentioning

confidence: 99%

200 years Aspidistra (Asparagaceae), and now more than 200 species: a new comprehensive determination key, and an annotated bibliography of the genus

Tillich

2023

Nordic Journal of Botany

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During the past decades the number of known species of Aspidistra (Asparagaceae) increased rapidly to 209. The present paper provides a comprehensive and detailed dichotomous key for the identification of all currently accepted species, subspecies and varieties. Additional information is provided concerning the distribution of each species, and its chromosome number(s). Furthermore, an annotated bibliography is added.

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“…Aspidistra has been used as traditional medicine to make tonics, expectorants, and diuretics, and to treat fractures, congestion, and snakebites [9–11] . In previous chemical investigations, the genus Aspidistra has been shown to contain xanthones, saponins, lectins, and homoisoflavones with a broad spectrum of biological activities, including antifungal, [12] antiviral, antitumor, [13] antibacterial, [14] and cytotoxic properties [15–17] …”

Section: Introductionmentioning

confidence: 99%

Antioxidant Activity of a New Xanthone Derivative from Aspidistra Letreae: In Vitro and In Silico Studies

Nguyen

et al. 2021

Chemistry & Biodiversity

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A new xanthone derivative, aspidxanthone A (1), and three known compounds ((2S)‐1‐(β‐D‐galactopyranosyloxy)‐3‐(hexadecanoyloxy)propan‐2‐yl (9Z,12Z)‐octadeca‐9,12‐dienoate (2), (25S)‐spirostane‐1β,3α,5β‐triol (3), and asparenyldiol (4)) were isolated from the whole of the endemic species Aspidistra letreae in Vietnam. Their structures were elucidated by means of extensive spectroscopic analyses and comparison with published data. In this study, we report the isolation and structure elucidation of a new compound aspidxanthone A, antioxidant activities of the extract and isolates 1–4, and in silico molecular docking of aspidxanthone A. The ethyl acetate extract had good antioxidant activity with an IC50 value of 26.3 μg mL−1. Among the isolates, aspidxanthone A exhibited DPPH reduction activity with an IC50 value of 11.2 μM, which is in the same range as that of the positive control, ascorbic acid. The mechanism of action of aspidxanthone A on the tyrosinase and xanthine oxidase proteins have been clarified by in silico studies.

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Aspidsaponins A–D, Four new steroidal saponins from the rhizomes of Aspidistra elatior Blume and their cytotoxicity

Cited by 13 publications

References 18 publications

Antitumor activities of Aspiletrein A, a steroidal saponin from Aspidistra letreae, on non-small cell lung cancer cells

Antitumor activities of Aspiletrein A, a steroidal saponin from Aspidistra letreae, on non-small cell lung cancer cells

200 years Aspidistra (Asparagaceae), and now more than 200 species: a new comprehensive determination key, and an annotated bibliography of the genus

Antioxidant Activity of a New Xanthone Derivative from Aspidistra Letreae: In Vitro and In Silico Studies

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