Asphericity of pretherapeutic tumour FDG uptake provides independent prognostic value in head-and-neck cancer

Apostolova, Ivayla; Steffen, Ingo G.; Wedel, Florian; Lougovski, Alexandr; Marnitz, Simone; Derlin, Thorsten; Amthauer, Holger; Buchert, Ralph; Hofheinz, Frank; Brenner, Winfried

doi:10.1007/s00330-014-3269-8

Cited by 70 publications

(91 citation statements)

References 27 publications

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“…Thirty-three patients, with LAHNC treated with RT-CT were included. Using the same cutoff of 20.4 found in (Apostolova et al, 2014), asphericity was correlated with PFS (HR 2.96, p = 0.015) and OS (HR 5.9, p = 0.001).…”

Section: Texture and Shape Analysismentioning

confidence: 78%

“…The authors validated their results on a dataset of 83 patients treated in the same institution after the original dataset (Tang et al, 2012). Based on (Apostolova et al, 2014), (Hofheinz et al, 2015) used a cutoff of TLG of 58.7 ml. They showed a correlation of TLG only with better DFS (HR 3.01, p = 0.048) but not with better OS (HR 2.02, p = 0.22).…”

Section: Discussionmentioning

confidence: 97%

“…(Apostolova et al, 2014) used a new parameter to characterize the deviation of the tumor's shape from sphere symmetry (asphericity). The initial assumption of the authors was that "aggressive" tumors are expected to show more irregular shapes, due to necrosis, angiogenesis and extravascular extracellular matrix.…”

Section: Texture and Shape Analysismentioning

confidence: 99%

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Overview of the predictive value of quantitative 18 FDG PET in head and neck cancer treated with chemoradiotherapy

Castelli

Bari

Depeursinge

et al. 2016

Critical Reviews in Oncology/Hematology

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International audience18 F-fluorodeoxyglucose (18F-FDG) positron emission tomography/computed tomography (PET/CT) allows to quantify the metabolic activity of a tumor (glycolysis) and has become a reference tool in oncology for the staging, restaging, radiotherapy planning and monitoring response in many cancers. Quantitative analyses have been introduced in order to overcome some of the limits of the visual methods, allowing an easier and more objective comparison of the inter- and intra-patients variations. The aims of this review were to report available evidences on the clinical value of quantitative PET/CT parameters in HNC. Forty-five studies, for a total of 2928 patients, were analyzed. Most of the data available dealt with the intensity of the metabolism, calculated from the Standard Uptake Value (SUV). Metabolic Tumor Volume (MTV) was well correlated with overall survival and disease free survival, with a higher predictive value than the maximum SUV. Spatial distribution of metabolism and textural analyses seems promising

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Section: Texture and Shape Analysismentioning

confidence: 78%

Section: Discussionmentioning

confidence: 97%

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Overview of the predictive value of quantitative 18 FDG PET in head and neck cancer treated with chemoradiotherapy

Castelli

Bari

Depeursinge

et al. 2016

Critical Reviews in Oncology/Hematology

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“…Despite these interesting results, the possibility of adopting their model in the clinical practice is limited by the monocentric nature of their study and by the definition of the cut-off of MTV based on populationdependent characteristics (from the 25th to the 75th percentile). Based on the results of a previous study [32], Hofheinz et al [29] used a cut-off of 58.7 ml for TLG. They showed a correlation of TLG only with better disease-free survival (DFS; HR 3.01, p Z 0.048) but not with OS (HR 2.02, p Z 0.22).…”

Section: Parametersmentioning

confidence: 99%

A PET-based nomogram for oropharyngeal cancers

Castelli

Depeursinge

Ndoh

et al. 2017

European Journal of Cancer

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Purpose: In the context of locally advanced oropharyngeal cancer (LAOC) treated with definitive radiotherapy (RT) (combined with chemotherapy or cetuximab), the aims of this study were: (1) to identify PET-FDG parameters correlated with overall survival (OS) from a first cohort of patients; then (2) to compute a prognostic score; and (3) finally to validate this scoring system in a second independent cohort of patients. Materials and methods: A total of 76 consecutive patients (training cohort from Rennes) treated with chemoradiotherapy or RT with cetuximab for LAOC were used to build a predictive model of locoregional control (LRC) and OS based on PET-FDG parameters. After internal calibration and validation of this model, a nomogram and a scoring system were developed and tested in a validation cohort of 46 consecutive patients treated with definitive RT for LAOC in Lausanne. Results: In multivariate analysis, the metabolic tumour volume (MTV) of the primary tumour and the lymph nodes were independent predictive factors for LRC and OS. Internal calibration showed a very good adjustment between the predicted OS and the observed OS at 24 months. Using the predictive score, two risk groups were identified (median OS 42 versus 14 months, p < 0.001) and confirmed in the validation cohort from Lausanne (median OS not reached versus 26 months, p Z 0.008). Conclusions: This is the first report of a PET-based nomogram in oropharyngeal cancer. Interestingly, it appeared stronger than the classical prognostic factors and was validated in independent cohorts markedly diverging in many aspects, which suggest that the observed signal was robust. ª

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“…Although many methods for evaluating the heterogeneity of intratumoral FDG uptake have been proposed [6,[9][10][11], cumulative SUV-volume histograms (CSH) and fractal analyses are considered to be simple methods for quantifying the intratumoral heterogeneity of FDG uptake [6,7]. CSH is obtained by plotting the percent area of a tumor with an SUV above a certain threshold against that threshold.…”

Section: Introductionmentioning

confidence: 99%

The influence of respiratory motion on the cumulative SUV-volume histogram and fractal analyses of intratumoral heterogeneity in PET/CT imaging

et al. 2016

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Asphericity of pretherapeutic tumour FDG uptake provides independent prognostic value in head-and-neck cancer

Abstract: Asphericity (ASP) characterises the spatial heterogeneity of FDG uptake in tumours. ASP is a promising prognostic parameter in head-and-neck cancer. ASP is useful for identification of high-risk patients with head-and-neck cancer.

Cited by 70 publications

References 27 publications

Overview of the predictive value of quantitative 18 FDG PET in head and neck cancer treated with chemoradiotherapy

Overview of the predictive value of quantitative 18 FDG PET in head and neck cancer treated with chemoradiotherapy

A PET-based nomogram for oropharyngeal cancers

The influence of respiratory motion on the cumulative SUV-volume histogram and fractal analyses of intratumoral heterogeneity in PET/CT imaging

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