Asperosin A, a [4 + 2] Diels–Alder cycloaddition polyketide dimer from Aspergillus rugulosa with immunosuppressive activity

Abstract

A novel homologous polyketide dimer, asperosin A (1), constructed by a unique hetero-bicycle 6/5 core skeleton featured four continuous quaternary carbon, was isolated from the solid culture of the fungus...

Prenyllongnols A–D, New Prenylated Acylphloroglucinols that Fight Concanavalin A-Induced Autoimmune Hepatitis

“…Our group was committed to the discovery of the agents against autoimmune hepatitis for a long time, such as kinsenoside, varioxepine B, and abietoquinone A; − the immune-related research is also a hot topic in various teams. − Therefore, an in vitro immunoassay was performed on prenyllongnols A–D ( 1 – 4 ), which were tested under the Con A-induced murine splenocyte proliferation conditions. As displayed in Table S2, prenyllongnols A, B, C, and D could inhibit murine splenocyte proliferation induced by Con A, with the IC 50 values of 3.44 ± 0.43, 2.98 ± 0.21, 5.31 ± 0.67, and 6.34 ± 0.72 μM, respectively.…”

Genome mining reveals a new cyclopentane-forming sesterterpene synthase with unprecedented stereo-control

“…In turn, we calculated the ECD of 1 and ent-1 at the PBE0-D3(BJ)/def2-TZVP level in MeOH. [19][20][21] Finally, according to the comparison of the experimental ECD curve and calculated ECD, the absolute configuration of 1 was determined to be 14R,15R,18S (Fig. 5).…”

Hot off the Press

“…A Diels–Alder cycloaddition between two polyketides has also been proposed for the formation of asperosin A 14 in Aspergillus rugulosa . 14 …”