Asperosaponin VI protects against bone destructions in collagen induced arthritis by inhibiting osteoclastogenesis

Liu, Kaifei; Liu, Ying; Xu, Yanting; Nandakumar, Kutty Selva; Tan, Huijing; He, Chonghua; Dang, Wen-Zhen; Lin, Jiahe; Zhou, Chun

doi:10.1016/j.phymed.2019.153006

Cited by 30 publications

(16 citation statements)

References 36 publications

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“…Among them, asperosaponin VI (ASA VI) is the one of the highest content of saponins ( Ding et al, 2019 ). The effects of ASA VI on proliferation and differentiation of osteoblasts has been widely reported ( Gao et al, 2016 , Liu et al, 2019 ). However, the role of ASA VI in innate immune regulation is unclear.…”

Section: Introductionmentioning

confidence: 99%

Asperosaponin VI inhibits LPS-induced inflammatory response by activating PPAR-γ pathway in primary microglia

Zhang

Xiao

et al. 2020

Saudi Journal of Biological Sciences

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Microglia cells are the main mediators of neuroinflammation. Activation of microglia often aggravates the pathological process of various neurological diseases. Natural chemicals have unique advantages in inhibiting microglia-mediated neuroinflammation and improving neuronal function. Here, we examined the effects of asperosaponin VI (ASA VI) on LPS-activated primary microglia. Microglia were isolated from mice and pretreated with different doses of ASA VI, following lipopolysaccharide (LPS) administration. Activation and inflammatory response of microglia cells were evaluated by real-time fluorescence quantitative polymerase chain reaction (q-PCR), immunohistochemistry and enzyme-linked immunosorbent assay (ELISA). Signaling pathways were detected by western blotting. We found that the ASA VI inhibited the morphological expansion of microglia cells, decreased the expression and release of proinflammatory cytokines, and promoted the expression of antiinflammatory cytokines in a dose-dependent manner. ASA VI also activated PPAR-γ signaling pathway in LPS-treated microglia. The anti-inflammatory effects of ASA VI in microglia were blocked by treating PPAR-γ antagonist (GW9662). These results showed that ASA VI promote the transition of microglia cells from proinflammatory to anti-inflammatory by regulating PPAR-γ pathway.

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Section: Introductionmentioning

confidence: 99%

Asperosaponin VI inhibits LPS-induced inflammatory response by activating PPAR-γ pathway in primary microglia

Zhang

Xiao

et al. 2020

Saudi Journal of Biological Sciences

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“…Asperosaponin VI inhibits osteoclastogenesis by reducing the expression of genes and markers of signaling pathways that lead to osteoclast proliferation. It protected mice with collagen-induced RA from bone destruction and bone loss [15].…”

Section: Saponinsmentioning

confidence: 99%

“…Alkaloids have mainly immunomodulatory action, regulating the cytokines IL-6, IL-12, IL-1α, TNF-α, IL-1β, and IL-10 [13]. Similarly, saponins also have immunostimulatory properties in RA, mainly in fibroblast-like synoviocytes [14][15][16].…”

Section: Introductionmentioning

confidence: 99%

Flavonoids, alkaloids and saponins: are these plant-derived compounds an alternative to the treatment of rheumatoid arthritis? A literature review

et al. 2021

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Rheumatoid arthritis (RA) is a systemic inflammatory disease characterized by synovial inflammation leading to progressive joint erosion and, eventually, joint deformities. RA treatment includes anti-inflammatories, corticosteroids, synthetic disease-modifying antirheumatic drugs (DMARDs), and immunosuppressants. Drug administration is associated with adverse reactions, as gastrointestinal ulcers, cardiovascular complications, and opportunistic infections. Wherefore, different plant-derived phytochemical compounds are studied like new therapeutic approach to treatment of RA. Among the phytochemical compounds of plants for treatment of RA, flavonoids, alkaloids and saponins are related for present anti-inflammatory activity and act as physiological and metabolic regulators. They have low toxicity compared to other active plant compounds, so their therapeutic properties are widely studied. The intention of the review is to present an overview of the therapeutics of flavonoids, alkaloids, and saponins for RA. An extensive literature survey was undertaken through different online platforms:PubMed, SciELO, and Virtual Health Library databases, to identify phytochemical compounds used in RA treatment and the descriptors used were medicinal plants, herbal medicines, and rheumatoid arthritis. Seventy-five research and review articles were found to be apt for inclusion into the review. The present study summarizes the phytochemicals isolated from plants that have therapeutic effects on RA models, in vitro and in vivo. The studied substances exerted anti-inflammatory, chondroprotective, immunoregulatory, anti-angiogenic, and antioxidant activities and the most compounds possess good therapeutic properties, valuable for further research for treatment of RA.

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“…During the ADME screening process, we noticed that some compounds, such as Aucubin, Geniposide, Geniposidic acid and Asperosaponin VI had high pharmacological activities, but they did not meet all the criteria. [26][27][28] Therefore, we have also retained them for subsequent analysis. Aer deleting repetitions, a total of 50 active compounds were screened, including 34 active compounds in EU, 20 active compounds in DR, and 4 shared compounds in EU and DR.…”

Section: Collection Of Active Compounds In Eu-drmentioning

confidence: 99%

Exploring the potential therapeutic effect of Eucommia ulmoides–Dipsaci Radix herbal pair on osteoporosis based on network pharmacology and molecular docking technology

et al. 2022

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Asperosaponin VI protects against bone destructions in collagen induced arthritis by inhibiting osteoclastogenesis

Cited by 30 publications

References 36 publications

Asperosaponin VI inhibits LPS-induced inflammatory response by activating PPAR-γ pathway in primary microglia

Asperosaponin VI inhibits LPS-induced inflammatory response by activating PPAR-γ pathway in primary microglia

Flavonoids, alkaloids and saponins: are these plant-derived compounds an alternative to the treatment of rheumatoid arthritis? A literature review

Exploring the potential therapeutic effect of Eucommia ulmoides–Dipsaci Radix herbal pair on osteoporosis based on network pharmacology and molecular docking technology

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