Asperolides A–C, Tetranorlabdane Diterpenoids from the Marine Alga-Derived Endophytic Fungus Aspergillus wentii EN-48

Sun, Huiling; Li, Xiaoming; Li, Meng; Cui, Chuan‐Ming; Gao, Shu-Shan; Li, Chun‐Shun; Huang, Chun; Wang, Bin‐Gui

doi:10.1021/np2006742

Cited by 102 publications

(98 citation statements)

References 25 publications

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“…have been found in many medicinal plants, including Taxus cuspidate (Zhao et al, 2009), Cephalotaxus mannii (Xue et al, 2012), Melia azedarach . Many antimicrobial compounds had been isolated and characterized from these endophytic fungi, such as diterpenoids (Sun et al, 2012), alkaloids (Zhan et al, 2007;Ding et al, 2012). Cephalosporium spp.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of antimicrobial activities of extracts of endophytic fungi from Artemisia annua

Zhang

2012

Bangladesh J Pharmacol

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The endophytic extracts of 11 fungi associated with asympomatic Artemisia annua Linn., were evaluated for antimicrobial activity against three human pathogenic microbes, Escherichia coli, Staphylococcus aureus and Trichophyton rubrum, and two plant pathogens, Rhizoctonia cerealis and Magnaporthe grisea. The results showed that these endophytic extracts had different inhibitory effects on microbial pathogens at 100 mg/mL. Among these fungal endophytes, three strains Aspergillus spp. SPS-02, SPS-04 and SPS-01 respectively showed the strongest antimicrobial activities against E. coli, S. aureu, T. rubrum. An endophytic Mucor sp. SPS-11 had the most pronounced effect on R. cerealis. Two strains Aspergillus sp. SPS-02 and Cephalosporium sp. SPS-08 exhibited the strongest antimicrobial activities against M. grisea. These anti-pathogenic endophytes could be applied as new sources of antibiotics in agriculture and pharmaceutical industry. Article Info

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Section: Discussionmentioning

confidence: 99%

Evaluation of antimicrobial activities of extracts of endophytic fungi from Artemisia annua

Zhang

2012

Bangladesh J Pharmacol

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“…5) (Slack et al 2009;Turner 1971;Turner and Aldridge 1983;Scheweikert 2003, Cole et al 2003), while section Cremei species can produce asperolides, anthraquinonederived bianthrons, leuconic acid, citraconic anhydrides and wentilactones uniquely (Fig. 5) (Verchère et al 1969;Turner 1971;Assante et al 1979;Dorner et al 1980;Selva et al 1980;Turner and Aldridge 1983;Scheweikert 2003, Cole et al 2003;Sun et al 2012). Asperglaucide from Aspergillus restrictus and Aspergillus penicillioides (Itabashi et al 2006) has a clear resemblance to asperphenamate found in Aspergillus flavipes in subgenus Circumdati section Flavipedes (Clark et al 1977).…”

Section: Unique Extrolites In Subgenus Fumigatimentioning

confidence: 99%

Chemodiversity in the genus Aspergillus

Frisvad

Larsen

2015

Appl Microbiol Biotechnol

113

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Isolates of Aspergillus species are able to produce a large number of secondary metabolites. The profiles of biosynthetic families of secondary metabolites are species specific, whereas individual secondary metabolite families can occur in other species, even those phylogenetically and ecologically unrelated to Aspergillus. Furthermore, there is a high degree of chemo-consistency from isolate to isolate in a species even though certain metabolite gene clusters are silenced in some isolates. Genome sequencing projects have shown that the diversity of secondary metabolites is much larger in each species than previously thought. The potential of finding even further new bioactive drug candidates in Aspergillus is evident, despite the fact that many secondary metabolites have already been structure elucidated and chemotaxonomic studies have shown that many new secondary metabolites have yet to be characterized. The genus Aspergillus is cladistically holophyletic but phenotypically polythetic and very diverse and is associated to quite different sexual states. Following the one fungus one name system, the genus Aspergillus is restricted to a holophyletic clade that include the morphologically different genera Aspergillus, Dichotomomyces, Phialosimplex, Polypaecilum and Cristaspora. Secondary metabolites common between the subgenera and sections of Aspergillus are surprisingly few, but many metabolites are common to a majority of species within the sections. We call small molecule extrolites in the same biosynthetic family isoextrolites. However, it appears that secondary metabolites from one Aspergillus section have analogous metabolites in other sections (here also called heteroisoextrolites). In this review, we give a genus-wide overview of secondary metabolite production in Aspergillus species. Extrolites appear to have evolved because of ecological challenges rather than being inherited from ancestral species, at least when comparing the species in the different sections of Aspergillus. Within the Aspergillus sections, secondary metabolite pathways seem to inherit from ancestral species, but the profiles of these secondary metabolites are shaped by the biotic and abiotic environment. We hypothesize that many new and unique section-specific small molecule extrolites in each of the Aspergillus will be discovered.

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“…The reported production of several other mycotoxins by A. wentii was mostly due to species misidentification or is doubtful (Frisvad et al 2005;Frisvad and Larsen 2015). Additional exometabolites were detected in A. wentii and related species by numerous studies (Reid 1975;Qureshi et al 1976;Dorner et al 1980;Selva et al 1980;Hamasaki and Kimura 1983;Frisvad and Samson 1991;Busi et al 2009;Siddhardha 2010;Zhang et al 2012;Xu et al 2015), some of them exhibited various significant biological activities.…”

Section: Introductionmentioning

confidence: 99%

Aspergillus europaeus sp. nov., a widely distributed soil-borne species related to A. wentii (section Cremei)

et al. 2016

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A new species belonging to Aspergillus section Cremei is described, A. europaeus sp. nov. This species is most closely related to A. wentii, A. dimorphicus, and A. chrysellus and can be distinguished by an unique phenotype (colour of sporulation, production of yellow soluble pigment on MEA, shape of vesicle, ornamentation of conidia), specific spectrum of produced exometabolites and internal transcribed spacers (ITS), b-tubulin and calmodulin gene sequence data. In total, 18 isolates were identified which originated from soil (n = 14), cork (n = 2), indoor air (n = 1) and clinical material (n = 1) in the Czech Republic, Romania, Spain, Portugal, France and Tunisia. All strains were first identified by morphological characters as A. wentii or A. tamarii suggesting that A. europaeus is a common species but it has been overlooked and frequently misidentified. The ex-type strain is CCF 4409 T = CBS 134393 T = IBT 32228 T = NRRL 66252 T .

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Asperolides A–C, Tetranorlabdane Diterpenoids from the Marine Alga-Derived Endophytic Fungus Aspergillus wentii EN-48

Cited by 102 publications

References 25 publications

Evaluation of antimicrobial activities of extracts of endophytic fungi from <i>Artemisia annua</i>

Evaluation of antimicrobial activities of extracts of endophytic fungi from <i>Artemisia annua</i>

Chemodiversity in the genus Aspergillus

Aspergillus europaeus sp. nov., a widely distributed soil-borne species related to A. wentii (section Cremei)

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