Aspergillus terreus Spondylodiscitis in an Immunocompromised Child

Sohn, Young Joo; Yun, Jung Ha; Yun, Ki Wook; Kang, Hyoung Jin; Choi, Eun Hwa; Shin, Hee Young; Lee, Hoan Jong

doi:10.1097/inf.0000000000002125

Cited by 11 publications

(12 citation statements)

References 10 publications

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“…Histopathological investigation and bacterial culture are the most reliable diagnosis procedures for Aspergillus spondylitis. Diagnostic imaging, such as CT and/or MRI, is necessary for disease staging and guiding orthopaedic and/or neurosurgical intervention [2,4,7]. In our case, the patient is known ALL, and radiological findings suggested infective spondylodiscitis at L4-L5.…”

Section: Discussionmentioning

confidence: 69%

“…Although Aspergillus spondylodiscitis is an uncommon opportunistic fungal infectious illness, it has recently overtaken Candida spondylitis in terms of occurrence. It most commonly arises in an immunocompromised host as a result of AIDS, organ transplantation, chemotherapy, or immunosuppressive medication, among other factors [2,7]. The patient in this case was immunocompromised, and the predominant focus of Aspergillus appeared to be pulmonary.…”

Section: Discussionmentioning

confidence: 78%

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A Rare Case of Aspergillus Spondylodiscitis In B-Cell Acute Lymphoid Leukemia

Sachin¹

2021

J Orth Rheumatol

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Section: Discussionmentioning

confidence: 69%

Section: Discussionmentioning

confidence: 78%

A Rare Case of Aspergillus Spondylodiscitis In B-Cell Acute Lymphoid Leukemia

Sachin¹

2021

J Orth Rheumatol

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“…35 This important association should be emphasized because of the increased number of immunocompromised patients during the last decades. 37,38 Moreover, considering that Aspergillus is the most common infection in solid organ transplant recipients, [39][40][41] it is important to highlight that any new back pain should raise suspicion of vertebral infection in this population. Our review yielded a relatively higher rate of postoperative complications in the 18 patients who received surgical intervention (33.6%; n 5 6) and a mortality rate of 17.5% (n 5 7).…”

Section: Lessonsmentioning

confidence: 99%

Primary spinal infections in patients with solid organ transplant: a systematic literature review and illustrative case

Hatter¹,

Beyer²,

Camino-Willhuber³

et al. 2022

Journal of Neurosurgery: Case Lessons

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BACKGROUND Primary spinal infections (PSIs) are a group of uncommon but serious infectious diseases considered more prevalent and aggressive among patients with chronic immunocompromised states. Association of PSI and solid organ transplant has not been systematically analyzed. The authors performed a systematic review analyzing clinical presentation and mortality of patients with PSI in the setting of solid organ transplant. OBSERVATIONS PSIs in patients with immunosuppressive therapy, such as those with solid organ transplant, may behave differently in terms of epidemiology, clinical presentation, and outcomes compared with nonimmunosuppressed patients. Overall PSI in solid organ transplant patients is associated with a high rate of neurological compromise, postoperative complications, and mortality. LESSONS Accurate diagnosis and appropriate treatment of PSI require a multidisciplinary effort. Localized pain is the most frequently reported symptom associated with PSI. As opposed to PSI in patients without transplant, inflammatory and infectious markers such as white blood cells and C-reactive protein are often not elevated. Furthermore, the causative microorganism profile varies significantly when compared to pyogenic spinal infection in patients without transplant. Aspergillus species was responsible for spondylodiscitis in transplant patients in more than 50% of cases, and the incidence of Aspergillus infection is projected to rise in the coming years.

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“…Spondylodiscitis is a rare but devastating disease that primarily affects the intervertebral disc and the adjacent vertebral bodies. A. terreus spondylodiscitis is even rare, with only ten reported cases ( Seligsohn et al., 1977 ; Glotzbach, 1982 ; Brown et al., 1987 ; Grandière-Perez et al., 2000 ; Park et al., 2000 ; Maman et al., 2015 ; Comacle et al., 2016 ; Sohn et al., 2019 ; Takagi et al., 2019 ; Vithiya et al., 2023 ). In this report, we present a rare case of A .…”

Section: Introductionmentioning

confidence: 99%

Aspergillus terreus spondylodiscitis following acupuncture and acupotomy in an immunocompetent host: case report and literature review

Jin,

Yin

2024

Front. Cell. Infect. Microbiol.

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Aspergillus terreus is a fungus responsible for various infections in human beings; however, spine involvement is uncommon. Herein, we report a case of A. terreus spondylodiscitis following acupuncture and acupotomy in an immunocompetent Chinese patient. Admission lumbar magnetic resonance imaging (MRI) revealed infection at the L4/5 level without significant vertebral destruction. After unsuccessful symptomatic and anti-tuberculosis treatments, A. terreus was identified through culture, microscopy of isolate, histological examination and VITEK system. Intravenous voriconazole was then given; however, the patient’s spinal condition deteriorated rapidly, resulting in evident destruction of the L4/5 vertebral bodies. Surgeries including L4/5 intervertebral disc debridement, spinal canal decompression, posterior lumbar interbody fusion (PLIF) with allogeneic fibula ring fusion cages, and posterior pedicle screw fixation were then performed. Imaging findings at one-month and six-month follow-up suggested that the patient was successfully treated. This case highlighted two important points: firstly, although acupuncture and acupotomy are generally regarded as safe conservative treatments for pain management, they can still lead to complications such as fungal spinal infection. Therefore, vigilance is necessary when considering these treatments; secondly, PLIF with allogeneic fibula ring fusion cages may be beneficial for A. terreus spondylodiscitis patients with spinal instability.

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Aspergillus terreus Spondylodiscitis in an Immunocompromised Child

Cited by 11 publications

References 10 publications

A Rare Case of Aspergillus Spondylodiscitis In B-Cell Acute Lymphoid Leukemia

A Rare Case of Aspergillus Spondylodiscitis In B-Cell Acute Lymphoid Leukemia

Primary spinal infections in patients with solid organ transplant: a systematic literature review and illustrative case

Aspergillus terreus spondylodiscitis following acupuncture and acupotomy in an immunocompetent host: case report and literature review

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