Aspergillus niger as a Secondary Metabolite Factory

Abstract

Aspergillus niger, one of the most common and important fungal species, is ubiquitous in various environments. A. niger isolates possess a large number of cryptic biosynthetic gene clusters (BGCs) and produce various biomolecules as secondary metabolites with a broad spectrum of application fields covering agriculture, food, and pharmaceutical industry. By extensive literature search, this review with a comprehensive summary on biological and chemical aspects of A. niger strains including their sources, BGCs, and secondary metabolites as well as biological properties and biosynthetic pathways is presented. Future perspectives on the discovery of more A. niger-derived functional biomolecules are also provided in this review.

Biocontrol Activity of Aspergillus terreus ANU-301 against Two Distinct Plant Diseases, Tomato Fusarium Wilt and Potato Soft Rot

“…Aspergillus , a well-known saprophytic filamentous fungal genus, play different biological roles in different niche, with Aspergillus niger and Aspergillus flavus being the most studied and significant species for their secondary metabolites ( Hossain et al, 2017 ; Park et al, 2017 ; Yu et al, 2021 ). A. terreus , a less well-known and explored microbe, was recently discovered to be a significant biological control agent and plant growth promoting microorganism ( Frisvad and Larsen, 2015 ; Vassileva et al, 2020 ).…”

Assignment of Absolute Configurations of Two Promising Anti-Helicobacter pylori Agents from the Marine Sponge-Derived Fungus Aspergillus niger L14

“…Endozoic strain L14 was isolated from fresh specimens (MNP-2016) of Reniera japonica collected at Xinghai Bay (Dalian, China), as described in the literature [ 11 ], and identified as A. niger according to its morphological characteristics and molecular phylogeny based on 18 S rDNA gene sequence (GenBank accession No. MF093522).…”

“…Among these microorganisms, fungi in particular can produce a large number of compounds with significant bioactivities [ 8 ]. As one of the most common and important filamentous fungi in nature, Aspergillus niger possesses great potential to produce a remarkable array of substances of biomedical and agricultural relevance, as well as food enzymes [ 9 , 10 , 11 ]. Our previous bioassay of endozoic microbes from a specimen (MNP-2016) of Reniera japonica collected off Xinghai Bay (China) led to the isolation of one fungus, A. niger L14, with strong antimicrobial effects [ 12 ].…”

Aurasperone A Inhibits SARS CoV-2 In Vitro: An Integrated In Vitro and In Silico Study

“…Aspergillus species have been reported to be significant suppliers of antiviral therapeutics [ 4 , 5 ]. Aspergillus niger is one of the most important and widely spread fungal species [ 8 ]. It is characterized by its ability to produce variable classes of natural products with different biological activities [ 8 , 9 ].…”

“…Aspergillus niger is one of the most important and widely spread fungal species [ 8 ]. It is characterized by its ability to produce variable classes of natural products with different biological activities [ 8 , 9 ]. It also represents a rich source for unpredicted and novel secondary metabolites due to the presence of cryptic biosynthetic gene clusters in its genome [ 8 , 10 ].…”