Aspergillus hepatic artery thrombosis in liver transplantation

Echeverri, Gabriel J.; Caicedo, Luis-Armando; Delgado, Alejandro; Thomas, Laura-Sofia; García, Víctor H.; Gómez, Catalina; Aristizábal, Ana M.; Arrunategui, Ana María; Rosso, Fernando

doi:10.1016/j.mmcr.2018.07.009

Cited by 4 publications

(3 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In one case, hepatic artery thrombosis and pseudoaneurysm linked to A. fumigatus were identified 1 month after LT surgery. 117 In the second case, postmortem examination showed destruction of the hepatic and renal arteries with Aspergillus and Mucor obstructing the artery lumen. 118 The mechanism leading to vascular involvement of Aspergillus in the vascular graft remains poorly understood and may result from colonization of the graft preservative fluid or from infection during surgery.…”

Section: Colonization Of Graft Preservation Fluid By Aspergillusmentioning

confidence: 94%

“…Two cases of hepatic artery thrombosis caused by Aspergillus were reported after liver transplantation. In one case, hepatic artery thrombosis and pseudoaneurysm linked to A. fumigatus were identified 1 month after LT surgery 117 . In the second case, postmortem examination showed destruction of the hepatic and renal arteries with Aspergillus and Mucor obstructing the artery lumen 118 .…”

Section: What Are the Risk Factors For Ia In Lt Patients?mentioning

confidence: 98%

See 1 more Smart Citation

Invasive aspergillosis in liver transplant recipients

Melenotte

Aimanianda

Slavin

et al. 2023

Transplant Infectious Dis

View full text Add to dashboard Cite

Background Liver transplantation is increasing worldwide with underlying pathologies dominated by metabolic and alcoholic diseases in developed countries. Methods We provide a narrative review of invasive aspergillosis (IA) in liver transplant (LT) recipients. We searched PubMed and Google Scholar for references without language and time restrictions. Results The incidence of IA in LT recipients is low (1.8%), while mortality is high (∼50%). It occurs mainly early (<3 months) after LT. Some risk factors have been identified before (corticosteroid, renal, and liver failure), during (massive transfusion and duration of surgical procedure), and after transplantation (intensive care unit stay, re‐transplantation, re‐operation). Diagnosis can be difficult and therefore requires full radiological and clinicobiological collaboration. Accurate identification of Aspergillus species is recommended due to the cryptic species, and susceptibility testing is crucial given the increasing resistance of Aspergillus fumigatus to azoles. It is recommended to reduce the dose of tacrolimus (50%) and to closely monitor the trough level when introducing voriconazole, isavuconazole, and posaconazole. Surgery should be discussed on a case‐by‐case basis. Antifungal prophylaxis is recommended in high‐risk patients. Environmental preventative measures should be implemented to prevent outbreaks of nosocomial aspergillosis in LT recipient units. Conclusion IA remains a very serious disease in LT patients and should be promptly sought and, if possible, prevented by clinicians when risk factors are identified.

show abstract

Section: Colonization Of Graft Preservation Fluid By Aspergillusmentioning

confidence: 94%

Section: What Are the Risk Factors For Ia In Lt Patients?mentioning

confidence: 98%

Invasive aspergillosis in liver transplant recipients

Melenotte

Aimanianda

Slavin

et al. 2023

Transplant Infectious Dis

View full text Add to dashboard Cite

show abstract

“…In Colombia, it has been estimated that almost 3000 cases of IA occur per year, from which 13% of cases are related to organ transplant recipients, especially those undergoing stem cell transplants [9]. Case reports with infrequent Aspergillus species or uncommon clinical presentations of aspergillosis have been also reported in Colombia [10][11][12][13][14], as well as aspergillosis in children [14][15][16][17], and reports of the presence of Aspergillus spores around hospitals, which increases the risk of patients developing aspergillosis [18,19]. However, there are no epidemiological studies with complete data on the occurrence of this mycosis in the country, which can serve to validate the estimated incidence.…”

Section: Introductionmentioning

confidence: 99%

Clinical and Epidemiological Profile of Patients with Invasive Aspergillosis from a Fourth Level Hospital in Bogota, Colombia: A Retrospective Study

Goyeneche-García

Rodríguez-Oyuela

Sánchez

et al. 2021

JoF

View full text Add to dashboard Cite

Invasive aspergillosis (IA) is a severe mycosis caused by Aspergillus species. The infection mainly affects immunocompromised patients with a significant clinical burden. This study aimed to determine the clinical and epidemiological characteristics of patients diagnosed with IA in a fourth level hospital in Colombia, as these data are scarce in the country. A retrospective, observational study, from a single center was conducted with 34 male and 32 female patients, between 1 month- and 90-year-old, diagnosed with proven (18.2%), probable (74.2%) and possible (7.6%) IA, during a 21-year period. The most frequent underlying conditions for IA were chemotherapy (39.4%) and corticosteroid use (34.8%). The lung was the most common affected organ (92.4%). Computed tomography (CT) imaging findings were mainly nodules (57.6%) and consolidation (31.8%). A low positive correlation was found between serum galactomannan and hospitalization length. Aspergillus fumigatus prevailed (73.3%) in sputum and bronchoalveolar lavage cultures. Most patients were hospitalized in general wards (63.6%) and treated with voriconazole (80.3%). Mortality rate was 15.2%. Common risk factors for IA were identified in the Colombian cohort, including medications and underlying diseases. However, their frequency differs from other countries, reinforcing the idea that local surveillance is essential and at-risk patients should be carefully monitored.

show abstract

Methylprednisolone/prednisolone/tacrolimus

2018

Reactions Weekly

View full text Add to dashboard Cite

Aspergillus hepatic artery thrombosis in liver transplantation

Cited by 4 publications

References 19 publications

Invasive aspergillosis in liver transplant recipients

Invasive aspergillosis in liver transplant recipients

Clinical and Epidemiological Profile of Patients with Invasive Aspergillosis from a Fourth Level Hospital in Bogota, Colombia: A Retrospective Study

Methylprednisolone/prednisolone/tacrolimus

Contact Info

Product

Resources

About