Aspergillus as a versatile cell factory for organic acid production

Yang, Lei; Lübeck, Mette; Lübeck, Peter Stephensen

doi:10.1016/j.fbr.2016.11.001

Cited by 100 publications

(54 citation statements)

References 162 publications

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“…This cycle includes reactions in which the oxalacetate interacts with Acetyl-CoA to form citric acid. In turn, citric acid undergoes two decarboxylation steps and other transformations to generate, again, oxalacetates: fumaric acid is one of the intermediates in such reactions [31,32]. The reductive pathway of the Krebs cycle is the main source of fumaric acid and involves fixation of CO 2 from a C3 acid to a C4 acid (pyruvate to oxalacetate).…”

Section: Fermentative Pathwaysmentioning

confidence: 99%

Fumaric Acid Production: A Biorefinery Perspective

et al. 2018

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The increasing scarcity of fossil raw materials, together with the need to develop new processes and technology based on renewable sources, and the need to dispose of an increasing amount of biomass-derived waste, have boosted the concept of biorefineries. Both 1G and 2G biorefineries are focused on the obtention of biofuels, chemicals, materials, food and feed from biomass, a renewable resource. Fumaric acid, and most compounds involved in the Kreb cycle, are considered key platform chemicals, not only for being acidulants and additives in the food industry, but also for their prospective use as monomers. This review is focused on the biotechnological processes based on fungi, mainly of the Rhizopus genus, whose main product is fumaric acid, on the process conditions, the bioreactors and modes of operation and on the purification of the acid once it is produced.

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Section: Fermentative Pathwaysmentioning

confidence: 99%

Fumaric Acid Production: A Biorefinery Perspective

et al. 2018

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“…Previous studies [36,37] have confirmed that fine RM particles are indicative of an iron oxide phase (e.g., hematite), while large and smooth particles are silicon compounds (e.g., sodalite and cancrinite). In view of the change in the micromorphology (i.e., disappearance of fine particles and emergence of a smooth layer on the surface of bioleached RM) as well as the change in the element composition of RM, it was concluded that iron oxides easily erode, while silicon compounds are difficult to erode or destroy by fungi activity.…”

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confidence: 86%

Selective Parameters and Bioleaching Kinetics for Leaching Vanadium from Red Mud Using Aspergillus niger and Penicillium tricolor

Hui

Wang

et al. 2019

Minerals

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In the present study, using Aspergillus niger and Penicillium tricolor, the influence of the selected parameters, including sucrose concentration, inoculation size of spores, pulp density, and pre-culture time, on the bioleaching efficiency (biomass, organic acids production, and vanadium extraction, respectively) of red mud were studied. The bioleaching kinetics under optimal conditions were also explored. Sucrose concentration showed a positive linear effect on bioleaching efficiency below 143.44 and 141.82 g/L using A. niger and P. tricolor, respectively. However, a higher concentration was unfavorable for vanadium extraction. The inoculation size of spores showed an insignificant effect on both biomass and vanadium extraction if it exceeded the lowest coded levels (0.5 × 107/mL). Red mud pulp density showed a negative effect on the bioleaching efficiency of A. niger but a positive effect on organic acids production and vanadium extraction of P. tricolor. A pre-culture was indispensable for A. niger but not for P. tricolor due to the fact of its isolation from the red mud examined in this study. The kinetics analysis showed that the leaching rate of vanadium followed a two-domain behavior: initially, a rapid leaching period of approximately 10–15 days and, subsequently, a slow leaching period. Considering the change of the particles’ appearance as well as in the elemental composition of the bioleached red mud, it is speculated that the rate of leaching agents through the silicon minerals was the rate-limiting step of dissolution kinetics under the fungal bioleaching process.

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“…O rganic acids present a group of bulk chemicals that have been widely used in the food, pharmaceutical, cosmetics, detergent, polymer, and textile industries. [1][2][3] According to one organic acid market analysis report, the global organic acid market is expected to reach $12.54 billion by 2026. 4 Organic acids can be specifically synthesized using chemical or biological methods.…”

Section: Introductionmentioning

confidence: 99%

Current advances in organic acid production from organic wastes by using microbial co‐cultivation systems

Qian

et al. 2019

Biofuels Bioprod Bioref

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The microbial production of organic acids has become a rapidly developing field due to their increasing global market. Recently, research has transitioned towards employing synthetic microbial consortia for organic acid production. Compared with pure cultures, microbial co‐cultures can perform more complex functions and endure more changeable environments. Accordingly, microbial co‐cultivation technologies for organic acid production have been adopted to fulfill the requirements for the utilization of a wider range of substrates for a higher product yield. Here, we have summarized current advances towards organic acid production from different substrates by using microbial co‐cultivation technologies. Furthermore, the construction mechanism of the microbial co‐cultivation systems was also analyzed and compared. © 2019 Society of Chemical Industry and John Wiley & Sons, Ltd.

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Aspergillus as a versatile cell factory for organic acid production

Cited by 100 publications

References 162 publications

Fumaric Acid Production: A Biorefinery Perspective

Fumaric Acid Production: A Biorefinery Perspective

Selective Parameters and Bioleaching Kinetics for Leaching Vanadium from Red Mud Using Aspergillus niger and Penicillium tricolor

Current advances in organic acid production from organic wastes by using microbial co‐cultivation systems

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