Aspergillosis of ethmoid sinus and optic nerve, with arteritis and rupture of the internal carotid artery

Corvisier, N.; Gray, Françoise; Gherardi, R; Lebras, F.; Blanc, Christelle; Nguyen, Justin; Poirier, Justin

doi:10.1016/0090-3019(87)90312-0

Cited by 34 publications

(12 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Consequently, the typical history is a chronic sinusitis with diffuse headache and rhinorrhea for months or years, followed by sudden visual disturbances or ocular motion impairment resulting from an orbital apex or a cavernous sinus syndrome. Involvement of the cavernous sinus with fungal thrombosis has a high mortality rate [1] and mycotic aneurysms or ruptures of the internal carotid artery are known severe complications [3] .…”

Section: Introductionmentioning

confidence: 99%

Invasive Sphenoidal Aspergillosis: Successful Treatment with Sphenoidotomy and Voriconazole

Baumann

Zimmerli

Häusler

et al. 2006

ORL

View full text Add to dashboard Cite

Treatment of invasive sphenoidal aspergillosis is surgical, followed by antifungal therapy, mostly amphotericin B. To optimize the adjuvant antifungal treatment, which is often limited by severe side effects, the new triazole antifungal agent voriconazole with broad coverage of fungal pathogens including Aspergillus was investigated in a study of 4 patients with clinical, radiological and histological signs of invasive sphenoidal aspergillosis. They first underwent endoscopic sphenoidotomy with drainage and extraction of the fungal mass. Postoperatively, 2 patients were immediately treated with voriconazole. Two patients initially received amphotericin B; but this treatment had to be stopped because of acute renal toxicity. Finally, all patients were treated orally with 200 mg voriconazole twice a day for 12–14 weeks. After this combined treatment all patients were asymptomatic and there were no endoscopic or radiological signs of residual fungal disease. The only side effects were nausea in one and transient visual disturbances in 2 other patients. In the 4 patients presented and treated, voriconazole was shown to be effective and less toxic than amphotericin B in adjuvant treatment of invasive sphenoidal aspergillosis.

show abstract

Section: Introductionmentioning

confidence: 99%

Invasive Sphenoidal Aspergillosis: Successful Treatment with Sphenoidotomy and Voriconazole

Baumann

Zimmerli

Häusler

et al. 2006

ORL

View full text Add to dashboard Cite

show abstract

“…There were two cases of ICA rupture without aneurysmal dilatation, but there have been no previous cases of fatal extracranial and intracranial hemorrhage due to Aspergillus arteritis [1,13]. In our patient, angiography showed narrowing of the paraclionid portion of the right ICA without any evidence of an aneurysm.…”

Section: Discussionmentioning

confidence: 41%

“…Generally, fungal aneurysms are quite large and occur on the circle of Willis. Four cases of pathologically proven subarachnoid hemorrhage due to Aspergillus arteritis of the ICA have been reported previously [1,5,13,15]. …”

Section: Discussionmentioning

confidence: 99%

Fatal hemorrhage from rupture of the intracranial internal carotid artery caused by aspergillus arteritis

et al. 1998

View full text Add to dashboard Cite

To the best of our knowledge, this is the first reported case of combined intracranial and extracranial hemorrhage due to aspergillus cerebral arteritis. Knowledge of the imaging and the importance of early diagnosis and treatment are emphasized. A 78 year old man developed progressive right-sided visual impairment and diplopia. Magnetic resonance imaging demonstrated a mass lesion located in the right orbital apex, with extension to the cavernous sinus and the right middle cranial fossa. Cerebral angiography showed no aneurysmal dilatation. He was scheduled for transnasal biopsy. However, the patient died of massive epistaxis and intracranial hemorrhage. Postmortem examination revealed an aspergillus granuloma of the orbit and the skull base involving the intracranial and extracranial internal carotid artery. Aspergillus fumigatus was identified by culture. The characteristic feature of the fungal infection is a low-intensity signal on T2-weighted magnetic resonance images. This finding may be useful in diagnosing fungal infection.

show abstract

“…Aspergillosis of the CNSis relatively rare, but the incidence of aspergillosis of the CNShas increased in recent years (1)(2)(3)(4)(5)(6).…”

Section: Discussionmentioning

confidence: 99%

“…Sometimes aspergillosis of CNScauses fatal SAH. It is assumed that Aspergillus has a tendency to invade the vessel walls leading to thrombosis or arteritis (3,5,6). However, the reason why Aspergillus is likely to invade vessel walls is not elucidated.…”

Section: Discussionmentioning

confidence: 99%

Aspergillus Aneurysm of the Middle Cerebral Artery Causing a Fatal Subarachnoid Hemorrhage.

et al. 1995

View full text Add to dashboard Cite

Aspergillosis of ethmoid sinus and optic nerve, with arteritis and rupture of the internal carotid artery

Cited by 34 publications

References 20 publications

Invasive Sphenoidal Aspergillosis: Successful Treatment with Sphenoidotomy and Voriconazole

Invasive Sphenoidal Aspergillosis: Successful Treatment with Sphenoidotomy and Voriconazole

Fatal hemorrhage from rupture of the intracranial internal carotid artery caused by aspergillus arteritis

Aspergillus Aneurysm of the Middle Cerebral Artery Causing a Fatal Subarachnoid Hemorrhage.

Contact Info

Product

Resources

About