Aspergillosis in Birds and Mammals: Considerations for Veterinary Medicine

Tell, Lisa A.; Burco, Julia D.; Woods, Leslie; Clemons, Karl V.

doi:10.1007/978-3-030-18586-2_4

Cited by 10 publications

(7 citation statements)

References 47 publications

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“…This brief overview highlights the difficulty in the diagnosis of aspergillosis in animals ( Elad and Segal, 2018 ; Tell et al., 2019 ). Antemortem lab-based methods derived from human medicine need to be implemented and validated with the goal to increase the accuracy of the diagnosis in animals.…”

Section: Discussionmentioning

confidence: 99%

“…For veterinarians and all staff that takes care of animals, the diagnosis of aspergillosis is often quite challenging because laboratories tools are neither numerous nor accurate enough ( Cray et al., 2009 ; Desoubeaux et al., 2018 ; Elad and Segal, 2018 ; Tell et al., 2019 ), and medical imaging is not readily available in every facility ( Jones and Orosz, 2000 ). Furthermore, there is no approved classification for helping to rank the cases according to the level of evidence, as is found in human medicine ( Donnelly et al., 2020 ).…”

Section: Introductionmentioning

confidence: 99%

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Challenges to establish the diagnosis of aspergillosis in non-laboratory animals: looking for alternatives in veterinary medicine and demonstration of feasibility through two concrete examples in penguins and dolphins

Désoubeaux

Cray

Chesnay

2022

Front. Cell. Infect. Microbiol.

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Aspergillosis remains difficult to diagnose in animals. Laboratory-based assays are far less developed than those for human medicine, and only few studies have been completed to validate their utility in routine veterinary diagnostics. To overcome the current limitations, veterinarians and researchers have to propose alternative methods including extrapolating from human diagnostic tools and using innovative technology. In the present overview, two specific examples were complementarily addressed in penguins and dolphins to illustrate how is challenging the diagnosis of aspergillosis in animals. Specific focus will be made on the novel application of simple testing in blood based on serological assays or protein electrophoresis and on the new information garnered from metabolomics/proteomics to discover potential new biomarkers. In conclusion, while the diagnostic approach of aspergillosis in veterinary medicine cannot be directly taken from options developed for human medicine, it can certainly serve as inspiration.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Challenges to establish the diagnosis of aspergillosis in non-laboratory animals: looking for alternatives in veterinary medicine and demonstration of feasibility through two concrete examples in penguins and dolphins

Désoubeaux

Cray

Chesnay

2022

Front. Cell. Infect. Microbiol.

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“…Bhattacharya (2003) declared that aspergillosis occurs sporadically in wild birds but commonly in commercial farms. Many species of Aspergillus including A. nidulus, A. flavus, A. niger can cause aspergillosis, but the most predominant cases are due to A. fumigatus which has very small spores in comparison to the spores of other Aspergillus fungi (Joseph, 2000;Beernaert et al, 2010;Tell et al, 2019).…”

Section: Discussionmentioning

confidence: 99%

The Effect of Aspergillus fumigatus Infection on Antibody Immune Response to Newcastle Disease Virus in Broiler Chickens.

Alazawy¹

2019

jwpr

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Aspergillus fumigatus infection might predispose birds to other respiratory infections with other pathogens such as Newcastle Disease Virus (NDV). This study aimed to investigate the incidence of Aspergillus fumigatus in commercial farms and its histopathological effects on respiratory organs and to evaluate the immunosuppressive effect of aspergillosis on NDV vaccinated birds. Aspergillus fumigatus was isolated from feedstuff and broilers in farms with respiratory manifestation. Twenty NDV-vaccinated broiler chickens of 10 days old were experimentally infected by feeding on feedstuff contaminated with Aspergillus fumigatus. Twenty vaccinated broilers but not fed the contaminated diet were used as the control group. Clinical signs, histopathological changes, NDV antibody levels in infected birds were recorded. Clinically, infected birds showed respiratory distress, dyspnea, gasping, ruffled feathers, green watery diarrhea, anorexia, lethargy, and unilateral drooping of wing. Histopathological changes were observed as disseminated granulomatous foci in the affected lungs, with caseous necrosis and leukocytes infiltration. The antibody immune response against NDV significantly reduced in infected birds compared with that of non-infected broilers. It is concluded, that Aspergillus fumigatus infection suppresses the immune responses and predisposes the broilers to other microbial infections, leading to considerable economic losses in the poultry industry.

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“…Aspergillus fumigatus causes frequent respiratory disease in birds called aspergillosis compared with other species, such as Aspergillus flavus , Aspergillus niger , Aspergillus Nidulans , and Aspergillus terreus [ 45 ]. Plant extracts contain phenolic compounds as potential antifungal and antiaflatoxigenic agents [ 46 ] using various mechanisms, such as inhibiting the production of aflatoxin B1, namely, syringaldehyde, sinapic acid, and acetosyringone [ 47 ], and decreasing A. flavus growth by targeting oxidative mitochondrial stress as a defense system using substances such as salicylic acid, thymol, vanillyl acetone, cinnamic acid, and vanillin [ 48 ].…”

Section: Antifungalmentioning

confidence: 99%

Review of herbal medicine works in the avian species

et al. 2021

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Poultry meat consumption is increasing worldwide but the overuse of antimicrobials for prevention and treatment of diseases has increased antimicrobial resistance (AMR), triggering a major public health issue. To restrict AMR emergence, the government supports the optimization of natural products that are safe and easy to obtain with minimal side effects on poultry, humans, and the environment. Various studies have explored the potential of herbs in animal health for their antiviral, antibacterial, antifungal, antiparasitic, immunomodulatory, antioxidant, and body weight gain properties. Therefore, this study reviewed plants with potential application in avian species by summarizing and discussing the mechanisms and prophylactic/therapeutic potential of these compounds and their plant origin extracts.

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Aspergillosis in Birds and Mammals: Considerations for Veterinary Medicine

Cited by 10 publications

References 47 publications

Challenges to establish the diagnosis of aspergillosis in non-laboratory animals: looking for alternatives in veterinary medicine and demonstration of feasibility through two concrete examples in penguins and dolphins

Challenges to establish the diagnosis of aspergillosis in non-laboratory animals: looking for alternatives in veterinary medicine and demonstration of feasibility through two concrete examples in penguins and dolphins

The Effect of Aspergillus fumigatus Infection on Antibody Immune Response to Newcastle Disease Virus in Broiler Chickens.

Review of herbal medicine works in the avian species

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