Aspergillosis complicating neoplastic disease

Meyer, Richard D.; Young, Lowell S.; Armstrong, Donald; Yu, Bessie

doi:10.1016/0002-9343(73)90077-6

Cited by 508 publications

(128 citation statements)

References 27 publications

Supporting

Mentioning

119

Contrasting

Unclassified

Order By: Relevance

“…Although the yield of SLB is much better than other procedures, it is not invariably diagnostic, and some diagnoses, such as aspergillosis, may be missed even with this procedure [11,12].…”

Section: Introductionmentioning

confidence: 99%

Surgical lung biopsy in patients with hematological malignancy or hematopoietic stem cell transplantation and unexplained pulmonary infiltrates: Improved Outcome with specific diagnosis

et al. 2005

View full text Add to dashboard Cite

Using a retrospective review of medical records, we sought the findings of surgical lung biopsy (SLB) in patients with hematological malignancy or hematopoietic stem cell transplantation (HSCT) and unexplained pulmonary infiltrates and to determine the impact of this procedure on management and outcome of these patients. Sixty-two patients who underwent SLB were evaluated; 31 patients had underlying hematological malignancy and 31 patients were HSCT recipients; 58% of whom underwent allogeneic HSCT. Thirty-three patients (53%) had focal infiltrates on chest CT scan while 29 (47%) had diffuse infiltrates. Thirteen patients were mechanically ventilated prior to SLB, and 27 (43%) were neutropenic. There were 66 diagnoses in the 62 patients, 44 (67%) were specific and 22 (33%) were nonspecific. The most common specific diagnoses were infection (29%), malignancy (27%), and inflammatory conditions (11%). Aspergillosis was the most common diagnosis of all biopsies (21%). SLB led to a change in therapy in 40% of patients and was associated with complications in 7 patients (11%). Specific diagnosis was more likely to lead to a change in therapy (48% vs. 27%, P = 0.06) and was associated with a lower mortality when compared to a nonspecific finding (30% vs. 59%, P = 0.02). Nonspecific diagnosis, on the other hand, was seen more in patients on mechanical ventilation prior to SLB compared to those off mechanical ventilation (69% vs. 27%, P = 0.02). SLB provides a specific diagnosis in the majority of patients with hematologic malignancy or HSCT recipients and unexplained pulmonary infiltrates. Specific diagnosis is more likely to lead to a change in therapy and is associated with a better outcome. Am. J. Hematol. 78:94-99, 2005. ª 2005 Wiley-Liss, Inc.

show abstract

“…Although the yield of SLB is much better than other procedures, it is not invariably diagnostic, and some diagnoses, such as aspergillosis, may be missed even with this procedure [11,12].…”

Section: Introductionmentioning

confidence: 99%

Surgical lung biopsy in patients with hematological malignancy or hematopoietic stem cell transplantation and unexplained pulmonary infiltrates: Improved Outcome with specific diagnosis

et al. 2005

View full text Add to dashboard Cite

show abstract

“…The combination of large samples, undamaged tissue compared to TBBX specimen, and direct visualization of the diseased lung made the sensitivity of this procedure greater than other procedures described previously (approximately 60-83%) [45,65,68,69]. The specificity when compared to autopsy findings is very high; however, IPA may not be reliably excluded by SLB [29,70].…”

Section: Surgical Lung Biopsymentioning

confidence: 93%

“…However, the sputum exam does not always provide reliable data because of [29]. The recovery of Aspergillus from lower respiratory tract cultures in HSCT has a positive predictive value of 82% [27].…”

Section: Sputum Examinationmentioning

confidence: 99%

“…Conversely, a negative sputum exam and culture for Aspergillus does not exclude IPA because negative sputum studies have been noted in 70% of confirmed cases [27]. Although the demonstration of tissue invasion is required for the definite diagnosis of IPA, the presence of Aspergillus species in the sputum cultures of HSCT recipients should be considered as indicative of invasive disease unless proven otherwise, and merits initiation of antifungal therapy [29].…”

Section: Sputum Examinationmentioning

confidence: 99%

See 1 more Smart Citation

Pulmonary complications following hematopoietic stem cell transplantation: Diagnostic approaches

et al. 2005

View full text Add to dashboard Cite

Pulmonary complications are a significant cause of morbidity and mortality in hematopoietic stem cell transplant recipients. Pulmonary infiltrates in such patients pose a major challenge for clinicians because of the wide differential diagnosis of infectious and noninfectious conditions. It is rare for the diagnosis to be made by chest radiograph, and commonly these patients will need further invasive and noninvasive studies to confirm the etiology of the pulmonary infiltrates. This review describes the role of the different diagnostic tools available to reach a diagnosis in a timely manner in this patient population. Am.

show abstract

“…1 The most frequently reported causative agents are Aspergillus fumigatus and A. flavus. 2 Aspergillus terreus has been shown to be a potential pathogen 3 and reported only rarely as an agent of human disease.…”

mentioning

confidence: 99%

PulmonaryAspergillosis Due to Aspergillus Terreus Var.Africanus in Acute Leukemia: Report of a Case and Review of the Literature

et al. 1989

View full text Add to dashboard Cite

Aspergillosis complicating neoplastic disease

Cited by 508 publications

References 27 publications

Surgical lung biopsy in patients with hematological malignancy or hematopoietic stem cell transplantation and unexplained pulmonary infiltrates: Improved Outcome with specific diagnosis

Surgical lung biopsy in patients with hematological malignancy or hematopoietic stem cell transplantation and unexplained pulmonary infiltrates: Improved Outcome with specific diagnosis

Pulmonary complications following hematopoietic stem cell transplantation: Diagnostic approaches

PulmonaryAspergillosis Due to Aspergillus Terreus Var.Africanus in Acute Leukemia: Report of a Case and Review of the Literature

Contact Info

Product

Resources

About