Asperger's Disorder and Co-Morbid Bipolar Disorder: Diagnostic and Treatment Challenges

Gutkovich, Zinoviy; Carlson, Gabrielle A.; Carlson, Harold E.; Coffey, Barbara J.; Wieland, Natalie

doi:10.1089/cap.2007.1723

Cited by 14 publications

(6 citation statements)

References 24 publications

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“…Twenty-four papers were deemed to potentially meet the review inclusion criteria. Of these, 18 papers were excluded, either as these constituted reviews (Carpenter, 2007;Schneier, Blanco, Antia & Liebowitz, 2002), or as there were no paranoia data about individuals with ASD (Skokauskas & Gallagher, 2012), or because the studies did not report outcome measures pertaining to paranoia in individuals with ASD (Bara, Ciaramidaro, Walter & Adenzato, 2011;Collacott, Cooper & McGrother, 1992;Couture, Penn, Losh, Adolphs, Hurley & Piven, 2009;Gutkovich, Carlson & Carlson, 2007;Hallerbäck, Lugnegård & Gillberg, 2012;Konstantareas & Hewitt, 2001;Murphy, 2006;Pary, 1993;Pilowsky, Yirmiya, Arbelle & Mozes, 2000;Prado de Oliveira, 1999;Shastri, Alla & Sabaratnam, 2006;Siegel et al, 2014;Travé Rodriguez, Barreiro Marin, Galvez Borrero, del Olmo Romero-Nieva & Diaz Alvarez, 1994;Yan et al, 2000), or as paranoia outcome data about individuals with ASD were subsumed and subsequently analysed in a more recent paper (Pinkham, Hopfinger, Pelphrey, Piven & Penn, 2008). One further study was identified which was published during manuscript preparation, and sub-group data were obtained MT personal communication, July 2015).…”

Section: Search Results and Data Extractionmentioning

confidence: 99%

Conceptualising paranoia in ASD: A systematic review and development of a theoretical framework

Spain

Sin

Freeman

2016

Research in Autism Spectrum Disorders

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Paranoia, unfounded ideation that others deliberately intend harm, has predominately been studied in schizophrenia. Increasingly, it is recognised that there is a spectrum of severity of excessive mistrust across the general population. Relatively little is known about paranoia in individuals with Autism Spectrum Disorders (ASD), but rates could be expected to be higher given both difficulties in understanding others' mental states and frequent experiences of negative social interactions. A systematic search of English-language peer-reviewed publications was undertaken to synthesise empirical research about paranoia in ASD. Seven studies, comprising a total of 180 ASD participants, met the inclusion criteria. All the studies were cross-sectional, thereby limiting causal interpretations. Individuals with ASD were consistently found to have higher levels of paranoia compared to non-clinical controls, and lower levels than individuals with current psychotic experiences manifesting in the context of schizophrenia. Furthermore, the initial evidence indicates that paranoia in ASD may be linked with theory of mind performance, negative affect, and jumping to conclusions, but not to attributional style. As in typically-developing populations, causal and maintaining mechanisms for paranoia in ASD, against a background of genetic and environmental risk, most likely include cognitive and affective processes interacting with social factors. We hypothesise, however, that core ASD characteristics and associated neurocognitive impairments also serve to precipitate and perpetuate paranoia. A framework to guide further investigation is outlined. Conceptualising paranoia in ASD 1 AbstractParanoia, unfounded fears ideation that others deliberately intend harm, has predominately been studied in schizophrenia. Increasingly, it is recognised that there is a spectrum of severity of excessive mistrust across the general population. Relatively little is known about paranoia in individuals with Autism Spectrum Disorders (ASD), but rates could be expected to be higher given both difficulties in understanding others' mental states and frequent experiences of negative social interactions. A systematic search of English-language peer-reviewed publications was undertaken to synthesise empirical research about paranoia in ASD. Seven studies, comprising a total of 180 ASD participants, met the inclusion criteria.All the studies were cross-sectional, thereby limiting causal interpretations. Individuals with ASD were consistently found to have higher levels of paranoia compared to non-clinical controls, and lower levels than individuals with current psychotic experiences manifesting in the context of schizophrenia. Furthermore, the initial evidence indicates that paranoia in ASD may be linked with theory of mind performance, negative affect, and jumping to conclusions, but not to attributional style. As in typically-developing populations, causal and maintaining mechanisms for paranoia in ASD, against a background of genetic and environ...

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Section: Search Results and Data Extractionmentioning

confidence: 99%

Conceptualising paranoia in ASD: A systematic review and development of a theoretical framework

Spain

Sin

Freeman

2016

Research in Autism Spectrum Disorders

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“…Comorbid conditions such as schizophrenia, bipolar disorder and attention-deficit hyperactivity disorder have been reported in Asperger's Syndrome 9,10). Furthermore, symptoms such as obsession may predict the prodromal phases of other psychiatric disorders.…”

Section: Discussionmentioning

confidence: 99%

Aripiprazole Improved Obsessive Compulsive Symptoms in Asperger's Disorder

Çelik

Tahiroğlu

Fırat

et al. 2011

Clin Psychopharmacol Neurosci

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There are many comorbid disorders associated with autism spectrum disorders in child and adolescent population. Although obsessive compulsive disorder and autism spectrum disorders (ASD) comorbidity has common in clinical practice, there are few reports about psychopharmacological treatment for obsessive compulsive symptoms in children with ASD in the literacy. We report a successful treatment case with aripiprazole in Asperger's Disorder with obsessive compulsive symptoms. The Yale Brown Obsessive Compulsive Scale was performed to assess symptom variety. This case report supports the effectiveness of aripiprazole in treatment of obsessive compulsive symptoms in Asperger's Disorder or ASDs. Aripiprazole may be beneficial to obsessive compulsive disorder comorbid autism spectrum disorders in child and adolescent age group.

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“…If these behaviors occur during episodes that represent a change from the person's usual function, both PDD and bipolar disorder are diagnosed (e.g., Gutkovich, Carlson, Carlson, Coffey, & Wieland, 2007;Wozniak et al, 1997).…”

Section: Treatment Of Bipolar Disorder In Developmentally Disabled Youthmentioning

confidence: 99%

“…Two case reports (Frazier & Jackson, 2008;Gutkovich, Carlson, Carlson, Coffey, & Wieland, 2007) describe risperidone's efficacy in autism spectrum youth with bipolar disorder. On the other hand, and very relevant for treatment of behaviors characteristic of mania, risperidone has been studied extensively in children and adolescents with irritable and agitated behavior in autism (e.g., and has recently received FDA approval for treatment of irritability and self-injurious behavior in autism.…”

Section: Atypical Antipsychoticsmentioning

confidence: 99%

Treating Childhood Psychopathology and Developmental Disabilities

2009

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Asperger's Disorder and Co-Morbid Bipolar Disorder: Diagnostic and Treatment Challenges

Cited by 14 publications

References 24 publications

Conceptualising paranoia in ASD: A systematic review and development of a theoretical framework

Conceptualising paranoia in ASD: A systematic review and development of a theoretical framework

Aripiprazole Improved Obsessive Compulsive Symptoms in Asperger's Disorder

Treating Childhood Psychopathology and Developmental Disabilities

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