Asperbutenolide A, an unusual aromatic butenolide dimer with diverse bioactivities from a marine-derived fungus Aspergillus terreus SCAU011

Biotransformation ability of endophytic fungi: from species evolution to industrial applications

“…MH665645 Isoshamixanthone Anticancer activity Kamel et al ( 2020 ) 78 Melia azedarach Linn Diaporthe eucalyptorum KACC48653 Eucalyptacid A Antifungal activity Gaoet al ( 2020b ) 79 Fucus vesiculosus Pyrenochaetopsis sp . FVE-001 Pyrenosetins A Anticancer activity Fan et al ( 2020 ) 80 Pyrenosetins B 81 Ceriops tagal Talaromyces assiutensis JN899320.1 Talarocyclopenta A Inhibitory effects nitric oxide production Cai et al ( 2020 ) 82 Asperitaconic B 83 Talarocyclopenta B Antibacterial activity and inhibitory effects nitric oxide production 84 Rhizophora stylosa Aspergillus terreus SCAU011 Asperbutenolide A Inhibition effect of COX-2 enzyme Bao et al ( 2020 ) 85 Acanthus ilicifolius L. Epicoccum nigrum SCNU-F0002 1-(4-hydroxy-2-methoxybenzofuran-5-yl)butan-1-one Antibacterial activity Yan et al ( 2019 ) 86 Vochysia divergens Diporthe vochysiae LGMF1583 Vochysiamide B Noriler et al ( 2019 ...…”

γ‐Aromatic Butenolides of Microbial Source – A Review of Their Structures, Biological Activities and Biosynthesis

“…As a class of γ ‐butenolides, γ ‐Aromatic butenolides ( γ ‐AB) are mainly derived from secondary products metabolized by microorganisms grown in harsh environments [7–9] . These microorganisms often lack physical protections to deter external threats and therefore, the γ ‐AB compounds are considered a kind of ‘chemical defense’, [10] In terms of structures, butenolactone compounds are similar to lignans, especially dibenzyltyrolactones.…”

A New Natural Butenolide, (5R)-3-Tetradecyl-5-methyl-2(5H)-furanone, from Octocoral Cladiella conifera

“…Chemical examination of the EtOAc soluble fraction of this specimen resulted in the isolation of a new natural butenolide derivative (5R)-3-tetradecyl-5-methyl-2(5H)-furanone (1) (Chart 1). Butenolide derivatives are occasionally encountered among various marine invertebrates, such as sponges, 3,4 brittle stars, 5 octocorals, [6][7][8] and marine microorganisms, including Gram-positive bacterium Streptomyces spp., 9,10 fungus Aspergillus terreus, 11,12 Paecilomyces variotii, 13 and Paradendryphiella salina. 14 These butenolides of marine origin were found to possess potential bioactivities in cytotoxicity, 5 antifouling activity, 8 PPARα agonistic activity, 9 α-glucosidase inhibitory activity, 11,12 anti-inflammatory activity, 12 antiradical activity, 12,13 and antibacterial effects.…”

“…Butenolide derivatives are occasionally encountered among various marine invertebrates, such as sponges, 3,4 brittle stars, 5 octocorals, [6][7][8] and marine microorganisms, including Gram-positive bacterium Streptomyces spp., 9,10 fungus Aspergillus terreus, 11,12 Paecilomyces variotii, 13 and Paradendryphiella salina. 14 These butenolides of marine origin were found to possess potential bioactivities in cytotoxicity, 5 antifouling activity, 8 PPARα agonistic activity, 9 α-glucosidase inhibitory activity, 11,12 anti-inflammatory activity, 12 antiradical activity, 12,13 and antibacterial effects. 12,14 As follows is the description of isolation, structural characterization, and bioactivity of butenolide 1.…”

“…14 These butenolides of marine origin were found to possess potential bioactivities in cytotoxicity, 5 antifouling activity, 8 PPARα agonistic activity, 9 α-glucosidase inhibitory activity, 11,12 anti-inflammatory activity, 12 antiradical activity, 12,13 and antibacterial effects. 12,14 As follows is the description of isolation, structural characterization, and bioactivity of butenolide 1. The IR spectrum pointed out an absorption at 1743 cm -1 , suggesting the presence of an α,β-unsaturated-γlactone carbonyl functional group.…”