Aspects ultrastructuraux des tumeurs de souris induites par l'adénovirus 12

Abstract

ULTRASTRUCTURAL ASPECTS OF MOUSE TUMORS INDUCED BY ADENOVTRUS 12In a study of the ultrastructure of tumors induced in mice by adenovirus 12, no intranuclear adenovirus particles could be found. In some nuclei, however, there were inclusions resembling those observed during the lytic cycles of adenovirus 12. There was an abundance of intracytoplasmic particles of type A and type C. Deposits of a very dense substance were found along the external surface of the cell membranes and also in the neighborhood of the Cparticles.

Ultrastructural Study of the Replication of Human Adenovirus Type 12 in Cultured Cells

“…With respect lo the morphological investigations, ultrastructu ral studies of cells infected with polyoma virus or with simian virus 40, as well as of cells transformed by adenovirus 12, have been carried out in this laboratory [1,8,9,25]. Altough the replicative cycle of human adenoviruses in cultured cells has been repeatedly studied at the light and electron microscopic levels [4.…”

Decreased interferon sensitivity and production in cells transformed by sv40 and other oncogenic agents

“…(2) Latent viruses might serve either as cocarcinogens, or " passenger viruses " in the methylcholanthrene-transformed cells, and might thus affect the sensitivity to the challenge virus. The contamination of transformed cell lines with passenger viruses is quite well known (Friedlander and Moore, 1956;Howatson and McCulloch, 1958;Granboulan et a/., 1960;Haguenau and Hollman, 1963;Bernhard and Tournier, 1964; Stenback at a/., Salomon, 1967;Hall et a/., 1967).…”