Aspects pharmacotechniques de la nutrition parentérale

Analysis of Sodium and Potassium in Total Parenteral Nutrition Bags by ICP-MS and ICP-AES:Critical Influence of the Ingredients

“…But, there is not the case for all of device and moreover, there don't measure the quantity of ingredients. On the other hand, the assay of electrolytes such as sodium and potassium is accepted as an end-product quality assurance marker [4][5][6][7] with which to estimate compounding errors and moreover, the errors on them are potentially serious clinical consequences [8].…”

“…There are some widely used analytical techniques for sodium and potassium quantification that are based on atomic emission spectrometry (flame photometry), inductively coupled plasma atomic emission spectrometry (ICP-AES) or quadrupole mass spectrometry (ICP-MS), capillary electrophoresis coupled with indirect UV detector or with capacitively coupled contactless conductivity detection, ion chromatography and electrochemical methods with ion sensitive (selective) electrodes [9][10][11][12][13][14][15][16]. Some of them were developed for the analysis of inorganic cations in pharmaceutical solutions and TPN such as flame photometry, selective electrode and capillary electrophoresis [5][6][7]17,18] but not always with successful results [6,17,18]. These results would be reliable to the fact that TPN have a high ionic force which product seriously distorted results for methods function activity and not concentration such as ion sensitive electrode.…”