Aspects of the natural history and virulence of S. agalactiae infection in Nile tilapia

Mian, Gláucia Frasnelli; Godoy, Daniel; Leal, Carlos Augusto Gomes; Yuhara, T.Y.; Costa, Geraldo Márcio da; Figueiredo, Henrique César Pereira

doi:10.1016/j.vetmic.2008.10.016

Cited by 229 publications

(191 citation statements)

References 16 publications

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“…Nile tilapia is one of the most important economical fishes and frequently subjected to disease by S. agalactiae in recent years, which becomes a big obstacle to tilapia aquaculture [31]. To understand the immune system and immune response against infection is useful for enhancing the immunity of cultured fish, which now becomes more and more important in aquatic research [32e34].…”

Section: Discussionmentioning

confidence: 99%

Molecular and functional characterization of peptidoglycan-recognition protein SC2 (PGRP-SC2) from Nile tilapia (Oreochromis niloticus) involved in the immune response to Streptococcus agalactiae

Gan

Chen

Hou

et al. 2016

Fish & Shellfish Immunology

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Section: Discussionmentioning

confidence: 99%

Molecular and functional characterization of peptidoglycan-recognition protein SC2 (PGRP-SC2) from Nile tilapia (Oreochromis niloticus) involved in the immune response to Streptococcus agalactiae

Gan

Chen

Hou

et al. 2016

Fish & Shellfish Immunology

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“…In China, more than 90% of the clinical bacterial isolates from infected tilapia since 2009 have been S. agalactiae (Chen et al 2012a). To date, S. agalactiae infection in tilapia outbreaks have been reported in several countries, including the USA (Evans et al 2006), China (Liu et al 2012), Kuwait (Evans et al 2002), Israel (Eldar et al 1994), Thailand (Suanyuk et al 2008), Honduras (Delannoy et al 2012), and Brazil (Mian et al 2009), resulting in serious annual economic losses.…”

Section: Introductionmentioning

confidence: 99%

Development of Streptococcus agalactiae vaccines for tilapia

Liu¹,

Zhu²,

Chen³

et al. 2016

Dis. Aquat. Org.

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Vaccination is a widely accepted and effective method to prevent most pathogenic diseases in aquaculture. Various species of tilapia, especially Nile tilapia Oreochromis niloticus, are farmed worldwide because of their high consumer demand. Recently, the tilapia-breeding industry has been hampered by outbreaks of Streptococcus agalactiae infection, which cause high mortality and huge economic losses. Many researchers have attempted to develop effective S. agalactiae vaccines for tilapia. This review provides a summary of the different kinds of S. agalactiae vaccines for tilapia that have been developed recently. Among the various vaccine types, inactivated S. agalactiae vaccines showed superior protection efficiency when compared with live attenuated, recombinant and DNA vaccines. With respect to vaccination method, injecting the vaccine into tilapia provided the most effective immunoprotection. Freund's incomplete adjuvant appeared to be suitable for tilapia vaccines. Other factors, such as immunization duration and number, fish size and challenge dose, also influenced the vaccine efficacy.

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“…After immunization 48 h and 72 h later, the mRNA expression of On-ZAP-70 was significantly upregulated in thymus, spleen and head kidney. This finding could be possibly associated with infection with S. agalactiae, which is a major cause of septicemia with high mortality in fish (Mian et al 2009). The head kidney and spleen, two major hematopoietic organs in teleost, are the main target organs attacked by S. agalactiae (Cornacchione b Fig.…”

Section: Discussionmentioning

confidence: 97%

“…Nile tilapia is one of the most economically important fishes and frequently subjected to disease caused by S. agalactiae in recent years, which threatens the development of tilapia aquaculture industry (Mian et al 2009). How to eliminate such severe disease has become an emergency, and this, to most extent, depends on the understanding of the immune responses induced by S. agalactiae.…”

Section: Discussionmentioning

confidence: 99%

Molecular characterization and expression of ZAP-70 in Nile tilapia (Oreochromis niloticus) in response to Streptococcus agalactiae stimulus

et al. 2015

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The 70 kDa zeta-chain associated protein kinase (ZAP-70) plays a critical role in effective signal transductions that are fundamental to T cell differentiation, proliferation and effector functions. In this paper, the ZAP-70 gene of Nile tilapia, Oreochromis niloticus (designated as On-ZAP-70) was cloned and its expression pattern under the stimulation of Streptococcus agalactiae was investigated. Sequence analysis showed important structural characteristics required for TCRs signal transduction were detected in the deduced amino acid sequence of On-ZAP-70, and the deduced genomic structure of On-ZAP-70 was similar to the known ZAP-70. In healthy tilapia, the On-ZAP-70 transcripts were mainly detected in the thymus, spleen, head kidney and gill. Moreover, there was a clear time-dependent expression pattern of On-ZAP-70 after immunization and the expression reached the highest level at 48 h in the spleen and head kidney, and at 72 h in the thymus, respectively. This is the first report on the expression of ZAP-70 induced by intracellular bacteria vaccination in teleosts. These findings indicated that On-ZAP-70 may play an important role in the immune response to intracellular bacteria in Nile tilapia.

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Aspects of the natural history and virulence of S. agalactiae infection in Nile tilapia

Cited by 229 publications

References 16 publications

Molecular and functional characterization of peptidoglycan-recognition protein SC2 (PGRP-SC2) from Nile tilapia (Oreochromis niloticus) involved in the immune response to Streptococcus agalactiae

Molecular and functional characterization of peptidoglycan-recognition protein SC2 (PGRP-SC2) from Nile tilapia (Oreochromis niloticus) involved in the immune response to Streptococcus agalactiae

Development of Streptococcus agalactiae vaccines for tilapia

Molecular characterization and expression of ZAP-70 in Nile tilapia (Oreochromis niloticus) in response to Streptococcus agalactiae stimulus

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