Aspects of the Chemical Stability of Mitomycin and Porfiromycin in Acidic Solution

Underberg, W.J.M.; Lingeman, H.

doi:10.1002/jps.2600720518

Cited by 44 publications

(18 citation statements)

References 13 publications

(9 reference statements)

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“…5,[14][15][16][17] The toxicity of these degradants is unknown. These degradants have been recognized, but prior studies have not assessed the percentage increase of degredants over time.…”

Section: Discussionmentioning

confidence: 99%

The Degradation of Mitomycin C Under Various Storage Methods

Kinast

Akula

DeBarber

et al. 2016

Journal of Glaucoma

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“…5,[14][15][16][17] The toxicity of these degradants is unknown. These degradants have been recognized, but prior studies have not assessed the percentage increase of degredants over time.…”

Section: Discussionmentioning

confidence: 99%

The Degradation of Mitomycin C Under Various Storage Methods

Kinast

Akula

DeBarber

et al. 2016

Journal of Glaucoma

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“…MMC is stable at pH 6 [21,22], Thiotepa and its active metabolite at alkaline pH (8.4) [23,24], whereas Doxorubicin is more stable in acidic pH [25]. The antitumor activity is also affected by pH.…”

Section: Pharmacokinetics and Absorption Of Intravesical Chemotherapementioning

confidence: 99%

Intravesical Chemotherapy and Chemohyperthermia in Non-Muscle-Invasive Bladder Cancer; An Overview on Drug Administration Technologies and Pharmacokinetics

Campodonico

Stasi

Lev³

et al. 2017

CDM

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Background: Tumor recurrence is the most expected clinical event after the resection of non-muscle invasive bladder cancer, depending on histological findings of the initial lesion. In patients with low and intermediate risk of disease, the intravesical instillation of chemotherapy agents is recommended as a standard treatment to reduce recurrences. Methods:A comprehensive review covering various aspects of different treatments with intravesical drugs is presented.Results: Drugs may be instilled into the bladder starting with a single, 'early' postoperative administration or, after tumor resection with adjuvant intent or, before tumor resection under a neo-adjuvant regimen. Both latter protocols would consist of weekly treatments followed by monthly maintenance treatments. Different methods of administering drugs intravesically have been proposed to enhance the depth of drug penetration and its absorption into the bladder wall thus increasing the rate of drug-DNA reaction. These device-assisted therapies therefore have set a goal to potentiate the drug's effect and efficaciousness. The Radiofrequency-Induced Thermochemotherapeutic Effect (RITE) and the Electromotive-Drug Administration (EMDA) are the two most relevant modalities used to increase the activity of intravesical chemotherapy. Despite the widely adopted international guidelines' recommendations, and recent clinical trials of device-assisted chemotherapy instillations showing markedly enhanced recurrence-free survival compared even to the standard of care, clinicians and pharmacologists are not familiar with the in-depth physical aspects, pharmacokinetics and systemic absorption of chemotherapeutic drugs following their intravesical administration. Conclusion:Knowledge of drug diffusion mechanisms into the tissue and cellular cytoplasm following bladder instillation is a key to understand the safety profile and clinical activity of chemotherapy.

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“…In the current study, HPLC-MS/MS was the chosen technique owing to its high sensitivity and the higher degree of specificity, the ability of an analytical technique to accurately measure the analyte in the presence of all potential sample matrix components without interference. Mitomycin C also has the problem of having a narrow range of stable conditions when in solution (18–20); thus, a procedure utilizing a simple dilution and without extensive sample pretreatment was necessary. Also, the developed method conforms to the validation requirements of the National Institute for Occupational Safety and Health (NIOSH) as well as the general accepted requirements of method validation (21, 22).…”

Section: Introductionmentioning

confidence: 99%

Validation of an HPLC-MS/MS and Wipe Procedure for Mitomycin C Contamination

B’Hymer

Connor

Stinson

et al. 2014

Journal of Chromatographic Science

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A high-performance liquid chromatography-tandem mass spectrometric (HPLC-MS/MS) method was developed for the determination of mitomycin C, an anticancer drug, from contamination on various surfaces. Mitomycin C is often used in various forms of intraperitoneal chemotherapy, and operating room healthcare worker exposure to this drug is possible. The surface testing method consisted of a wiping procedure utilizing a solution of 20/45/35 (v/v/v) of acetonitrile-isopropanol-water made 0.01 M in ammonium citrate (apparent pH 7.0). The wipe solutions were analyzed by means of HPLC-MS/MS using a reversed-phase gradient system and electrospray ionization in positive ion-mode with a triple-quadrupole mass spectrometric detector. Accuracy and precision of this method were demonstrated by a series of recovery studies of both spiked solutions and extracted wipes from various surfaces (stainless steel, vinyl and Formica®) spiked with known levels of mitomycin C. Recoveries of spiked solutions containing the analyte demonstrate mean recoveries (accuracy) ranged from 93 to 105%. Precision as measured by the relative standard deviation (%RSD) of multiple samples (n=10) at each concentration level demonstrated values of 7.5% or less. The recoveries from spiked surfaces varied from 30 to 99%. The limit of detection (LOD) for this methodology is approximately 2 ng/100 cm2 equivalent surface area, and the limit of quantitation (LOQ) is approximately 6 ng/100 cm2.

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Aspects of the Chemical Stability of Mitomycin and Porfiromycin in Acidic Solution

Cited by 44 publications

References 13 publications

The Degradation of Mitomycin C Under Various Storage Methods

The Degradation of Mitomycin C Under Various Storage Methods

Intravesical Chemotherapy and Chemohyperthermia in Non-Muscle-Invasive Bladder Cancer; An Overview on Drug Administration Technologies and Pharmacokinetics

Validation of an HPLC-MS/MS and Wipe Procedure for Mitomycin C Contamination

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