Aspects of the bioinorganic chemistry of aluminium(III) relevant to the metal toxicity

Corain, Benedetto; Nicolini, Marino; Zatta, Paolo

doi:10.1016/0010-8545(92)80004-b

Cited by 31 publications

(11 citation statements)

References 48 publications

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“…Also, Roy et al (1988), Greger et al (1992 and Tan et al (1993) have detected antagonistic effects of Mg towards Al-toxicity. This exceptional feature of Mg2+ might be due to the similar iondiameters of Mg2+ and Al" (Corain et al 1992). The roles of Mg2+ and P in connection with Al-toxicity clearly open a promising field of research.…”

Section: Resultsmentioning

confidence: 97%

Influence of available aluminium on soil micro-organisms

Illmer

Marschall

Schinner

1995

Lett Appl Microbiol

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P. ILLMER, K. MARSCHALL AND F. SCHINNER. 1995. Forest soils were selected which covered a wide range of aluminium concentrations (7 to μmol g‐1dry matter), but which differed as little as possible from one another in their soil chemical characteristics, including pH. These soils were examined with respect to microbial biomass and respiration, activity of cellulase, N‐mineralization, colony‐forming units of bacteria and fungi, and the concentrations of several inorganic soil components. The influences of altitude, climate, vegetation and, especially, of soil acidity could be kept to a minimum and so differences between the soil microfloras could clearly be attributed to Al concentration. Al concentration was recognized to be the main inhibiting factor for the microbial biomass in soil. While N‐mineralization was severely inhibited by aluminium, cellulase activity was hardly affected by increasing Al concentrations. By taking the Al concentration along with various other soil chemical parameters a linear model could be developed that allowed more than 98% of the variability of the microbial biomass in soil to be explained.

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Section: Resultsmentioning

confidence: 97%

Influence of available aluminium on soil micro-organisms

Illmer

Marschall

Schinner

1995

Lett Appl Microbiol

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“…No ß-turn was observed in the structuration of these two peptide Nevertheless, residues Lys 3 is includes in a γ-type local conformation, as can be concluded from the intrachain hydrogen bond between Se^NH and Ala^CO (75% occurrence) and the dihedral angle values of Lys 3 The A and Β chains form a loop which is tethered to the aluminum atom by the Se^OH and Asn 9 COO" groups. Contrary to the Β chain, the A chain loop is stabilized by at least three hydrogen bonds (Figure 2) Thus, the folding of the C-terminal part of the peptide allows the formation of the Gln 5 A NH to Asn 9…”

Section: Refined Al 3+ -Thymulin Structuresmentioning

confidence: 84%

REFINED SOLUTION STRUCTURE OF Al3+-THYMULIN COMPLEXES BASED ON RESTRAINED MOLECULAR DYNAMICS CALCULATIONS

Laussac¹,

Arnaúd²,

Orlewski³

et al. 1997

Main Group Metal Chemistry

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We report the solution three-dimensional structure of complexes of Al 3+ with thymulin, a linear nonapeptide of thymic origin isolated from serum. Structural determination was performed by distance geometry and molecular dynamics calculations in a DMSO solvent box, by using NOE-derived distance restraints. Two distinct conformers (parallel and antiparallel), as a consequence of aluminum coordination, were characterized. A tightly folded structure appears for both conformers with several γ-turns and a loop region stabilized by aluminum coordination via the Se^OH and the Asn 9 COO" groups and by several intra-and intermolecular interactions. Comparison of the solution structures of these two complexes suggests that the antiparallel isomer should be mainly present in solution.

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“…Toxicological studies on aluminum always have to take the different aluminum species and the pH‐dependent availability of aluminum into consideration [18]. Decreasing the pH of Al solutions and complex formation will necessarily lead to a reduced Al toxicity [3]. Thus for experimental reasons, a distinct exclusion or proof of Al effects on motility has not been possible yet.…”

Section: Discussionmentioning

confidence: 99%

“…Several toxic effects of aluminum on organisms have been established but the interactions of the effects and the molecular mechanisms are still not understood [2]. Although most data concerning Al toxicity are derived from experiments with plants, animals and man [1–4], microorganisms have also been shown to be distinctly inhibited through high levels of available Al in soil [5–7]. However, a great problem of all investigations on Al toxicity is to distinguish between the Al toxicity itself and the effects of Al‐induced pH decrease [8].…”

Section: Introductionmentioning

confidence: 99%

Influence of aluminum on motility and swarming of Pseudomonas sp. and Arthrobacter sp.

Illmer

Schinner

2006

FEMS Microbiology Letters

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The effect of Al on the motility and the swarming of Pseudomonas sp. and Arthrobacter sp. was investigated. pH calibration curves were determined in semi‐solid agar which enabled us to distinguish between the effects of aluminum and protons. Motility of the bacteria was distinctly influenced by Al but this effect could be attributed to the increased acidity accompanying Al addition. The swarming of Pseudomonas sp. is reported for the first time. The swarming ability decreased with both Al and HCl addition to the medium but the obstruction due to aluminum was significantly stronger than the influence of HCl.

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Aspects of the bioinorganic chemistry of aluminium(III) relevant to the metal toxicity

Cited by 31 publications

References 48 publications

Influence of available aluminium on soil micro-organisms

Influence of available aluminium on soil micro-organisms

REFINED SOLUTION STRUCTURE OF Al3+-THYMULIN COMPLEXES BASED ON RESTRAINED MOLECULAR DYNAMICS CALCULATIONS

Influence of aluminum on motility and swarming of Pseudomonas sp. and Arthrobacter sp.

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