Aspects of speech rate and regularity in Parkinson's disease

Skodda, Sabine

doi:10.1016/j.jns.2011.07.020

Cited by 71 publications

(37 citation statements)

References 56 publications

(79 reference statements)

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“…This is clinically relevant to humans as this may contribute to premature loss of the bolus to the pharynx, resulting in aspiration before the swallow. The study also demonstrated variability in swallowing outcome measures at 4 months, which may be explained by increased within-individual variability often seen in motor tasks such as walking, finger tapping, speech, and swallowing [30, 38–40]. …”

Section: Discussionmentioning

confidence: 99%

Pink1 −/− Rats Show Early-Onset Swallowing Deficits and Correlative Brainstem Pathology

et al. 2018

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Parkinson disease (PD) compromises oropharyngeal swallowing, which negatively affects quality of life and contributes to aspiration pneumonia. Dysphagia often begins early in the disease process, and does not improve with standard therapies. As a result, swallowing deficits are undertreated in the PD population. The Pink1 −/− rat is used to model PD, and demonstrates widespread brainstem neuropathology in combination with early-onset sensorimotor dysfunction; however, to date, swallowing behaviors have not been evaluated. To test the hypothesis that Pink1 −/− rats demonstrate early-onset differences in swallowing, we analyzed within-subject oropharyngeal swallowing using videofluoroscopy. Pink1 −/− and wildtype (WT) controls at 4 (Pink1 −/− n = 16, WT = 16) and 8 (Pink1 −/− n = 12, WT = 12) months of age were tested. The average and maximum bolus size was significantly increased in Pink1 −/− rats at both 4 and 8 months. Bolus average velocity was increased at 8 months for all animals; yet, Pink1 −/− animals had significantly increased velocities compared to WT at 8 months. The data show a significant reduction in mastication rate for Pink1 −/− rats at 8 months suggesting the onset of oromotor dysfunction begins at this time point. Relationships among swallowing variables and neuropathological findings, such as increased alpha-synuclein protein in the nucleus ambiguus and reductions in noradrenergic cells in the locus coeruleus in the Pink1 −/− rats, were determined. The presence of early oropharyngeal swallowing deficits and relationships to brainstem pathology in Pink1−/− rat models of PD indicate that this may be a useful model of early swallowing deficits and their mechanisms. These findings suggest clinical implications for early detection and management of dysphagia in PD.

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Section: Discussionmentioning

confidence: 99%

Pink1 −/− Rats Show Early-Onset Swallowing Deficits and Correlative Brainstem Pathology

et al. 2018

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“…In PD, speech rate has been reported to be normal (Skodda, 2011;Walsh & Smith, 2012), increased (Moreau et al, 2007;Skodda & Schlegel, 2008), or decreased (Ho et al, 1998;Sachin et al, 2008). These discrepancies may stem from differences in the speech tasks or disease severity of the subjects across these studies.…”

Section: Discussionmentioning

confidence: 99%

Differences in early speech patterns between Parkinson variant of multiple system atrophy and Parkinson’s disease

et al. 2015

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“…Similarly, Parkinson's disease, which is characterized by decreased movement amplitude and speed, also includes abnormalities in movement variability. Abnormalities of speech in Parkinsons' disease can include low volume and reduced amplitude of articulation, but also include increased variability of articulation, which can contribute significantly to loss of intelligibility (Skodda 2011). Similarly, freezing of gait in Parkinson's disease may follow steps that have increased variability in their size and timing (e.g.…”

Section: Cortico-basal Ganglia Circuits and Reward And Motor Learningmentioning

confidence: 99%

Translating Birdsong: Songbirds as a Model for Basic and Applied Medical Research

Brainard

Doupe²

2013

Annu. Rev. Neurosci.

198

187

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Songbirds, long of interest to basic neuroscientists, have great potential as a model system for translational neuroscience. Songbirds learn their complex vocal behavior in a manner that exemplifies general processes of perceptual and motor skill learning, and more specifically resembles human speech learning. Song is subserved by circuitry that is specialized for vocal learning and production, but that has strong similarities to mammalian brain pathways. The combination of a highly quantifiable behavior and discrete neural substrates facilitates understanding links between brain and behavior, both normally and in disease. Here we highlight 1) behavioral and mechanistic parallels between birdsong and aspects of speech and social communication, including insights into mirror neurons, the function of auditory feedback, and genes underlying social communication disorders, and 2) contributions of songbirds to understanding cortical-basal ganglia circuit function and dysfunction, including the possibility of harnessing adult neurogenesis for brain repair.

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Aspects of speech rate and regularity in Parkinson's disease

Cited by 71 publications

References 56 publications

Pink1 −/− Rats Show Early-Onset Swallowing Deficits and Correlative Brainstem Pathology

Pink1 −/− Rats Show Early-Onset Swallowing Deficits and Correlative Brainstem Pathology

Differences in early speech patterns between Parkinson variant of multiple system atrophy and Parkinson’s disease

Translating Birdsong: Songbirds as a Model for Basic and Applied Medical Research

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