Aspects of Histopathologic Subtype as a Prognostic Factor in 85 Pleural Mesotheliomas

Johansson, Leif; Lindén, Carl-Johan

doi:10.1378/chest.109.1.109

Cited by 70 publications

(45 citation statements)

References 20 publications

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“…sarcomatous or mixed histology), thrombocytosis, fever of unknown origin, age w65 yrs, and poor Karnofsky index. A more favourable prognosis is associated with epithelial histology, stage I disease (particularly if the disease is localized to the parietal pleura), absence of chest pain, and the presence of symptoms for v6 months before diagnosis [90,177].…”

Section: Mesotheliomamentioning

confidence: 99%

Management of malignant pleural effusions

et al. 2001

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Section: Mesotheliomamentioning

confidence: 99%

Management of malignant pleural effusions

et al. 2001

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“…The mice were monitored clinically and body weight was measured. Tumor volume was calculated as 0.52 Â length Â width 2 , where length and width are the largest and smallest extents of the palpable tumor. FITC-labeled lectin (4.5 mg/kg) was infused into animals 30 minutes before sacrifice.…”

Section: V -Tacctgaaggtcaggcgcac-3vmentioning

confidence: 99%

“…There are three main histologic types of malignant mesothelioma (i.e., epitheloid, mixed or biphasic, and sarcomatoid), with survival being higher with the epitheloid and shorter with the sarcomatoid type (2). There is a strong association with asbestos exposure with f80% of malignant mesothelioma occurring in individuals who have ingested or inhaled asbestos.…”

mentioning

confidence: 99%

Up-Regulation of EphB4 in Mesothelioma and Its Biological Significance

Xia

Kumar²,

Masood³

et al. 2005

Clinical Cancer Research

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Purpose: Mesothelioma is a rare malignancy that is incurable and carries a short survival despite surgery, radiation, or chemotherapy.This study was designed to identify novel targets for diagnostic, prognostic, and therapeutic approaches. Experimental Design: The expression and functional significance of the receptor tyrosine kinase EphB4 was studied in vitro and in a murine model of mesothelioma. Results: EphB4 was highly expressed in mesothelioma cell lines and primary tumor tissues but not in normal mesothelium. Knockdown of EphB4 using small interfering RNA and antisense oligodeoxynucleotide showed reduction in cell survival, migration, and invasion. EphB4 knockdown initiated a caspase-8-mediated apoptosis and down-regulation of the antiapoptotic protein bcl-xl. EphB4 knockdown also resulted in reduced phosphorylation of Akt and down-regulation of matrix metalloproteinase-2 transcription. In addition, murine tumor xenograft studies using EphB4 oligodeoxynucleotides showed a marked reduction in tumor growth accompanied by a specific decline in EphB4 protein levels, reduced cell division, apoptosis in tumor tissue, and decreased microvascular density. Conclusions: EphB4 is expressed in mesothelioma, provides a survival advantage to tumor cells, and is therefore a potential novel therapeutic target.

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“…Tumor cells were spindle shaped with a pseudosarcomatous pattern (Fig 7a) and exhibited densely packed nuclei with very small amounts of cytoplasm. 10,14,18 No interstitial edematous areas were seen. This pattern is suggestive of a mechanical barrier.…”

Section: Q5mentioning

confidence: 93%

Regression of AK7 malignant mesothelioma established in immunocompetent mice following intratumoral gene transfer of interferon gamma

et al. 2003

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Malignant mesothelioma (MM) is a lethal tumor linked with a prior exposure to asbestos in which limited progress has been made so far using conventional therapies. MM is an example of a ''nonimmunogenic'' tumor characterized by a fibrous stroma and an absence of infiltrating T lymphocytes. High levels of transforming growth factor-beta (TGF-b) produced by mesothelioma cells have been related to the immune tolerance towards the tumor. In order to evaluate the effect of local delivery of cytokines such as interferon gamma (IFN-g) by gene transfer, we characterized and used a murine model, AK7, which appeared very similar to human mesothelioma. AK7 cells expressed low levels of major histocompatibility class I and class II antigens and secreted high levels of latent TGF-b. The TGF-b pathway in AK7 cells is operative but inefficient because endogenous TGF-b is predominantly inactive. Treatment of pre-established AK7 tumors by direct intratumoral injection of an adenovirus vector expressing murine IFN-g, Ad.mIFN-g, led to significant tumor regression. Peripheral tumor infiltration by CD4+ and CD8+ T lymphocytes in the treated tumors appeared to be because of the induction of an immune response. Tumor relapse was observed, which could be due to local TGF-b secretion by remaining tumor cells.

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Aspects of Histopathologic Subtype as a Prognostic Factor in 85 Pleural Mesotheliomas

Cited by 70 publications

References 20 publications

Management of malignant pleural effusions

Management of malignant pleural effusions

Up-Regulation of EphB4 in Mesothelioma and Its Biological Significance

Regression of AK7 malignant mesothelioma established in immunocompetent mice following intratumoral gene transfer of interferon gamma

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