Aspects of Fetal Physiology From 18 to 37 Weeks' Gestation as Assessed by Blood Sampling

Nava, S.; Bocconi, Luisa; Zuliani, G.; Kustermann, Alessandra; Nicolini, Umberto

doi:10.1016/0029-7844(96)00056-7

Cited by 44 publications

(45 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Although synthesis occurs in a variety of tissues, most circulating IGF-1 is produced by the liver. The increase of IGF-1 levels with gestation is not surprising in view of the observed rise in blood concentration of all other indices of liver synthesis [18]. In addition, similar changes have been reported to occur in fetal insulin levels [23].…”

Section: Discussionmentioning

confidence: 62%

See 1 more Smart Citation

Insulinlike Growth Factor 1 in Controls and Growth-Retarded Fetuses

et al. 1998

View full text Add to dashboard Cite

Objectives: To establish a reference range of insulinlike growth factor 1 (IGF-1) values in normal fetuses and to assess whether intrauterine growth retardation is associated with increased or decreased IGF-1 levels. Methods: Retrospective analysis of blood samples collected from 64 fetuses who underwent blood sampling at 18–38 weeks’ gestation was performed: 40 fetuses, who were considered controls, were appropriately grown for gestational age and were found unaffected by the condition for which they were tested; the remainder (n = 24) underwent fetal blood sampling to assess fetal karyotype and acid-base balance following ultrasonic diagnosis of intrauterine growth retardation. (In this group, 8 survived, and 16 died during the perinatal period). IGF-1 was measured using a radioimmunoassay after acid-ethanol extraction in order to avoid interference by the binding proteins. All samples from controls and growth-retarded fetuses were measured using the same batch, and the intra-assay coefficient of variation of the test ranged from 4.1 to 6.1%. Results: In control fetuses, IGF-1 serum levels increased linearly with gestational age. In growth-retarded fetuses, IGF-1 levels were not significantly different from the reference range (median Z-score –0.3; range –4.4 to 291) and did not correlate with fetal size, hematocrit, and acid-base balance values. There was a significant difference in IGF-1 and pH values when the fetuses were divided into two groups based on the perinatal outcome: those who survived had values of IGF-1 mostly within the normal range, whereas the fetuses who died in utero or postnatally had significantly decreased pH and elevated IGF-1 values (median Z-score 2.1; 95% confidence interval 0.4–13.9; p = 0.04). Conclusions: This study confirms previous observations that IGF-1 levels parallel the increase in fetal size which occurs with advancing gestation. Increased levels of IGF-1 may indicate a terminal process in the fetal adaptation to placental failure.

show abstract

Section: Discussionmentioning

confidence: 62%

“…The same procedure was adopted to describe hematocrit and acidbase balance [18]. Comparisons were made using unpaired testing (parametric or nonparametric, as appropriate, after analysis of the distribution of values by histograms).…”

Section: Methodsmentioning

confidence: 99%

Insulinlike Growth Factor 1 in Controls and Growth-Retarded Fetuses

et al. 1998

View full text Add to dashboard Cite

show abstract

“…Guignard et al [26] studied rabbit mothers and fetuses and demonstrated an equilibration between maternal and fetal plasma creatinine concentrations. In a study of 157 fetuses and 134 mothers who underwent fetal blood sampling from 18-37 weeks gestation, Nava et al [27] observed that maternal and fetal concentrations of glucose (r ¼ 0.79, P < 0.001), urea (r ¼ 0.96, P < 0.001), creatinine (r ¼ 0.83, P < 0.001), and uric acid (r ¼ 0.94, P < 0.001) correlated significantly. As such, serum creatinine in the newborn largely reflects maternal creatinine.…”

Section: Key Pointsmentioning

confidence: 99%

Assessment of glomerular filtration rate in the neonate

Filler

Guerrero-Kanan

Álvarez-Elías

2016

Current Opinion in Pediatrics

View full text Add to dashboard Cite

show abstract

“…23 Normal val ues reported for fetal al bumi n and total protei n are gi ven i n Tabl e 2. 24,25 When coupl ed w i th val ues of fetal bl ood compositi on i n TTTS (Tabl e 2) 7,26 and compared w i th l evel s i n normal pregnancy, there i s evi dence for our hypothesi s that the severe pol yhydramni os may be l i nked to i ncreased COP i n the reci pi ent tw i n w hi ch enhances absorpti on of w ater from the mother.…”

Section: Twin Researchmentioning

confidence: 99%

Maternal metabolic abnormalities in twin–to–twin transfusion syndrome at mid–pregnancy

Lia

Kuhlmann²,

Emery³

2000

twin res

View full text Add to dashboard Cite

We r epor t abnor mal mater nal l abor ator y par ameter s i n tw i n-to-tw i n tr ansfusi on syndr ome (TTTS) at mi d-pr egnancy. A r etr ospecti ve char t r evi ew w as under tak en of 109 pati ents w i th TTTS eval uated for pl acental l aser sur ger y. Compl ete bl ood count (CBC), bl ood type and Rh factor, ur i ne anal ysi s and ser um chemi str y panel w er e obtai ned pr eoper ati vel y, w i th the CBC and ser um al bumi n r epeated on the fi r st postoper ati ve day. The mean gestati onal age w as 21.2 ± 1.7 w eek s. I ni ti al abnor mal val ues i ncl uded hematocr i t (32.1 ± 3.0%), hemogl obi n (11.0 ± 1.03 g/dl ), ser um magnesi um (1.71 ± 0.17 mg/dl ), total pr otei n (6.08 ± 0.55 g/dl ) and al bumi n (3.06 ± 0.34 g/dl ). Despi te mi ni mal bl ood l oss and conser vati ve fl ui d r epl acement mean hematocr i t, hemogl obi n, and al bumi n w er e 27.3 ± 2.74%, 9.3 ± 0.94 g/dl and 2.56 ± 0.23 g/dl , r especti vel y on postoper ati ve day one. Wei ght gai n (8.0 ± 5.5 l b.) and l ow ur i nar y output w er e char acter i sti c per i -oper ati ve events. M ater nal hypopr otei nemi a and anemi a occur i n TTTS at mi d-pr egnancy. Thi s may contr i bute i ndependentl y to amni oti c fl ui d pr oducti on r ates i n the fetuses, and expl ai n i n par t the mater nal sensi ti vi ty to i ntr avenous fl ui ds i n mul ti pl e pr egnancy. Twin Research (2000) 3, 113-117.Keyw or ds: pregnancy compl i cati on, mul ti pl e gestati on, monochori oni c tw i ns, tw i n-to-tw i n transfusi on syndrome, pol yhydramni os, hypoprotei nemi a, anemi a, col l oi d osmoti c pressure

show abstract

Aspects of Fetal Physiology From 18 to 37 Weeks' Gestation as Assessed by Blood Sampling

Cited by 44 publications

References 29 publications

Insulinlike Growth Factor 1 in Controls and Growth-Retarded Fetuses

Insulinlike Growth Factor 1 in Controls and Growth-Retarded Fetuses

Assessment of glomerular filtration rate in the neonate

Maternal metabolic abnormalities in twin–to–twin transfusion syndrome at mid–pregnancy

Contact Info

Product

Resources

About