Aspects of corneal transplant immunology

Zarei-Ghanavati, Mehran; Liu, Christopher

doi:10.4103/jovr.jovr_115_17

Cited by 3 publications

(2 citation statements)

References 19 publications

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“…Some limitations of tissue-engineered corneal transplants are suboptimal integration and the risk of tissue rejection, especially in the case of treating acutely damaged and highly inflamed tissues [ 37 , 182 ]. Poor interactions between the graft and host tissue could influence multiple molecular events, including healing, inflammation, ECM remodeling, and cell death at the graft host site [ 16 , 129 , 183 ]. Corneal scaffold fabrication with nanomaterials has the potential to improve the physicochemical properties that enhance graft integration in the host tissue [ 129 ].…”

Section: Perspective On Translating Existing Knowledge Of Ecm-based S...mentioning

confidence: 99%

Human SMILE-Derived Stromal Lenticule Scaffold for Regenerative Therapy: Review and Perspectives

Santra

Liu

Jhanji

et al. 2022

IJMS

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A transparent cornea is paramount for vision. Corneal opacity is one of the leading causes of blindness. Although conventional corneal transplantation has been successful in recovering patients’ vision, the outcomes are challenged by a global lack of donor tissue availability. Bioengineered corneal tissues are gaining momentum as a new source for corneal wound healing and scar management. Extracellular matrix (ECM)-scaffold-based engineering offers a new perspective on corneal regenerative medicine. Ultrathin stromal laminar tissues obtained from lenticule-based refractive correction procedures, such as SMall Incision Lenticule Extraction (SMILE), are an accessible and novel source of collagen-rich ECM scaffolds with high mechanical strength, biocompatibility, and transparency. After customization (including decellularization), these lenticules can serve as an acellular scaffold niche to repopulate cells, including stromal keratocytes and stem cells, with functional phenotypes. The intrastromal transplantation of these cell/tissue composites can regenerate native-like corneal stromal tissue and restore corneal transparency. This review highlights the current status of ECM-scaffold-based engineering with cells, along with the development of drug and growth factor delivery systems, and elucidates the potential uses of stromal lenticule scaffolds in regenerative therapeutics.

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Section: Perspective On Translating Existing Knowledge Of Ecm-based S...mentioning

confidence: 99%

Human SMILE-Derived Stromal Lenticule Scaffold for Regenerative Therapy: Review and Perspectives

Santra

Liu

Jhanji

et al. 2022

IJMS

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“…One of the main limitations of artificial corneal transplants is poor integration with native host tissues and high rejection rates due to various immune responses in native corneal tissues, which are especially acute in the damaged area [8]. The problems of interactions between a tissue-engineered (TE) graft and the host microenvironment will be further discussed in this review, as well as the recent studies on the multiple molecular mechanisms modulating the processes of healing, inflammation, and remodeling of the extracellular matrix (ECM) [9] and cell death [10][11][12].…”

Section: Introductionmentioning

confidence: 99%

Tissue Engineering Meets Nanotechnology: Molecular Mechanism Modulations in Cornea Regeneration

et al. 2021

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Nowadays, tissue engineering is one of the most promising approaches for the regeneration of various tissues and organs, including the cornea. However, the inability of biomaterial scaffolds to successfully integrate into the environment of surrounding tissues is one of the main challenges that sufficiently limits the restoration of damaged corneal tissues. Thus, the modulation of molecular and cellular mechanisms is important and necessary for successful graft integration and long-term survival. The dynamics of molecular interactions affecting the site of injury will determine the corneal transplantation efficacy and the post-surgery clinical outcome. The interactions between biomaterial surfaces, cells and their microenvironment can regulate cell behavior and alter their physiology and signaling pathways. Nanotechnology is an advantageous tool for the current understanding, coordination, and directed regulation of molecular cell–transplant interactions on behalf of the healing of corneal wounds. Therefore, the use of various nanotechnological strategies will provide new solutions to the problem of corneal allograft rejection, by modulating and regulating host–graft interaction dynamics towards proper integration and long-term functionality of the transplant.

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Clinical Outcomes of Accelerated Corneal Cross-Linking for Pediatric Keratoconus

Salman

Darwish

Ghabra

et al. 2021

Journal of Ophthalmology

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Aim. To assess the efficacy and safety of accelerated corneal cross-linking in the treatment of pediatric keratoconus. Method. In this retrospective case series, 29 eyes of 20 pediatric patients with keratoconus underwent accelerated corneal cross-linking. Treatment was delivered at 10 mW/cm2 for 9 minutes with a total dose of 5.4 J/cm2. Clinical evaluation included visual acuities and refractive and Scheimpflug corneal tomography assessments. All patients with a minimum follow-up duration of 24 months were included in the study. Results. Mean ± standard deviation age was 15.41 ± 2.13 years (range: 8 to 18 years). Uncorrected distance visual acuity improved significantly from 0.56 ± 0.28 to 0.42 ± 0.29 logMAR P = 0.0003 , and corrected distance visual acuity improved significantly from 0.34 ± 0.23 to 0.28 ± 0.22 logMAR P = 0.014 . The mean manifest refraction spherical equivalent value was significantly reduced (−0.59 ± 0.95 D, P = 0.0024 ). While mean flat keratometry and steep keratometry values were not significantly altered ( P > 0.05 for both), the mean maximum keratometry value was significantly decreased from 56.97 ± 5.24 D preoperatively to 55.84 ± 5.37 D at 24 months postoperatively P = 0.003 . Maximum keratometry had progressed by >1 D in two eyes (6.89%). Permanent corneal haze was reported in one case (3.44%). Conclusion. Our 24-month follow-up demonstrated that accelerated corneal cross-linking appears to halt the progression of keratoconus in pediatric patients without apparent complications. Uncorrected and corrected distance visual acuities were also improved.

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Aspects of corneal transplant immunology

Cited by 3 publications

References 19 publications

Human SMILE-Derived Stromal Lenticule Scaffold for Regenerative Therapy: Review and Perspectives

Human SMILE-Derived Stromal Lenticule Scaffold for Regenerative Therapy: Review and Perspectives

Tissue Engineering Meets Nanotechnology: Molecular Mechanism Modulations in Cornea Regeneration

Clinical Outcomes of Accelerated Corneal Cross-Linking for Pediatric Keratoconus

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