Aspects of Cardiometabolic Risk in Women with Polycystic Ovary Syndrome

Paterakis, Thomas; Diamanti-Kandarakis, Evanthia

doi:10.1007/s13679-014-0127-6

Cited by 8 publications

(5 citation statements)

References 103 publications

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“…Women with PCOS in our meta-analysis also show significant alterations in anthropometric, metabolic and hormonal parameters compared with the control group, with increased values of BMI, WHR, FPG, TC and TG, as well as testosterone. It is known that these anthropometric, metabolic and hormonal abnormalities might contribute to the increased risk of cardiovascular diseases in women with PCOS (Christakou and Diamanti-Kandarakis, 2013;Diamanti-Kandarakis and Dunaif, 2012;Paterakis and Diamanti-Kandarakis, 2014;Pertynska-Marczewska et al, 2015). Similarly, these concomitant metabolic and hormonal features might have partly contributed to the cardiovascular autonomic dysfunction in women with PCOS (Esler et al, 2006;Lambert et al, 2015;Sverrisdottir et al, 2008), as discussed in the following three paragraphs.…”

Section: Discussionmentioning

confidence: 96%

Cardiovascular autonomic dysfunction in women with polycystic ovary syndrome: a systematic review and meta-analysis

Gui

Wang

2017

Reproductive BioMedicine Online

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Recent studies reveal that polycystic ovary syndrome (PCOS) might be associated with cardiovascular autonomic dysfunction, but with inconsistent results. The aim of this meta-analysis was to study whether women with PCOS have cardiovascular autonomic dysfunction. PubMed, Web of Science, Cochrane Library and SCOPUS were searched for studies comparing cardiovascular function between women with PCOS and controls. A random-effects model was used to evaluate cardiac autonomic modulation and muscle sympathetic nerve activity (MSNA) between women with PCOS and controls. Eight studies were included, including 243 PCOS and 211 controls. Overall, women with PCOS had significantly lower standard deviation of normal-to-normal RR intervals (SDNN) and percentage of the number of interval differences of successive normal-to-normal RR intervals greater than 50 ms among the total number of RR intervals (pNN50), higher MSNA frequency and higher MSNA incidence than controls. Therefore, this meta-analysis provides evidence that women with PCOS might show cardiovascular autonomic dysfunction, with reduced total and parasympathetic cardiac modulation, and increased sympathetic activity.

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Section: Discussionmentioning

confidence: 96%

Cardiovascular autonomic dysfunction in women with polycystic ovary syndrome: a systematic review and meta-analysis

Gui

Wang

2017

Reproductive BioMedicine Online

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“…As it was stated above, the PCOS women have an increased basal insulin secretion, although the insulin secretory response to glucose loading as a whole is inadequate, as compared to that of healthy women [43,53]. On tissue level, IR develops in the liver, adipose tissue, and muscles of PCOS women.…”

Section: Carbohydrate Disturbances and Insulin Resistance In Pcosmentioning

confidence: 99%

Clinical Impact of Insulin Resistance in Women with Polycystic Ovary Syndrome

Orbetzova¹

2020

Polycystic Ovarian Syndrome

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Polycystic ovary syndrome (PCOS) is an endocrine-metabolic disorder characterized by multiple hormonal imbalances, reflecting on the clinical presentation. Among them, the insulin resistance (IR), defined as a metabolic state characterized by a decrease in cellular ability to respond to insulin signaling, is a key feature of PCOS independently of obesity. Thus, IR occurs in more than 70% of obese PCOS women and in 30-50% of lean ones. Compensatory high insulin levels are both a symptom and an underlying physiopathological driver of PCOS. Insulin appears to disrupt all components of the hypothalamic-pituitary-ovarian axis, and ovarian tissue IR results in impaired metabolic signaling but intact mitogenic and steroidogenic activity, favoring hyperandrogenemia. The latter is the main culprit of the clinical picture in PCOS. Testing for IR can be helpful to rule out other conditions that are commonly misdiagnosed as PCOS and to recommend an appropriate treatment for the different PCOS phenotypes.

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“…Moreover, the active AGE-RAGE axis contributes to the atherosclerosis as well as the endothelial dysfunction (77). Although all these predisposing factor to cardiovascular disease it remains uncertain whether they result in a higher mortality rate (78, 79).…”

Section: Common Findingsmentioning

confidence: 99%

Polycystic Ovary Syndrome and NC-CAH: Distinct Characteristics and Common Findings. A Systematic Review

et al. 2019

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Background: Twenty-one-hydroxylase–deficient non-classic adrenal hyperplasia (NC-CAH) is a very common autosomal recessive syndrome with prevalence between 1:1,000 and 1:2,000 individuals and the frequency varies according to ethnicity. On the other hand, polycystic ovary syndrome has a familial basis and it is inherited under a complex hereditary trait. This syndrome affects 6 to 10% of women in reproductive age and it is the most common endocrine disorder in young women. Our aim was to investigate, through a systematic review, the distinct characteristics and common findings of these syndromes. Methods: The search period covered January 1970 to November 2018, using the scientific databases PubMed. Inclusion criteria were adult women patients with PCOS or NC-CAH. Search terms were “polycystic ovary syndrome,” “PCOS,” “non-classical adrenal hyperplasia,” “NC-CAH,” “21-hydroxylase deficiency.” From an initial 16,255 titles, the evaluations led to the final inclusion of 97 papers. Results: The clinical features of NC-CAH are hirsutism and ovulatory and menstrual dysfunction therefore; differentiation between these two syndromes is difficult based on clinical grounds only. Additionally, NC-CAH and PCOS are both associated with obesity, insulin resistance, and dyslipidaemia. Reproductive abnormalities are also common between these hyperandrogenemic disorders since in patients with NC-CAH polycystic ovarian morphology and subfertility are present as they are in women with PCOS. The diagnosis of PCOS, is confirmed once other disorders that mimic PCOS have been excluded e.g., conditions that are related to oligoovulation or anovulation and/or hyperandrogenism, such as hyperprolactinaemia, thyroid disorders, non-classic congenital adrenal hyperplasia, and androgen-producing neoplasms. Conclusions: The screening tool to distinguish non-classic adrenal hyperplasia from PCOS is the measurement of 17-hydroxyprogesterone levels. The basal levels of 17-hydroxyprogesterone may overlap, but ACTH stimulation testing can distinguish the two entities. In this review these two common endocrine disorders are discussed in an effort to unveil their commonalities and to illuminate their shadowed distinctive characteristics.

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Aspects of Cardiometabolic Risk in Women with Polycystic Ovary Syndrome

Cited by 8 publications

References 103 publications

Cardiovascular autonomic dysfunction in women with polycystic ovary syndrome: a systematic review and meta-analysis

Cardiovascular autonomic dysfunction in women with polycystic ovary syndrome: a systematic review and meta-analysis

Clinical Impact of Insulin Resistance in Women with Polycystic Ovary Syndrome

Polycystic Ovary Syndrome and NC-CAH: Distinct Characteristics and Common Findings. A Systematic Review

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