Aspects of Attention Predict Real-World Task Performance in Alzheimer's Disease

Miloyan, Beyon; Razani, Jill; Larco, Andrea; Avila, Justina F.; Chung, Julia

doi:10.1080/09084282.2012.685133

Cited by 14 publications

(8 citation statements)

References 54 publications

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“…A very recent study found that performance on tasks requiring working memory and complex attention were related to real-world task performance [36]. Executive functioning also has been noted as a mediator between other cognitive domains and daily functioning [21] and associated with higher number of falls and gait speed slowing [37].…”

Section: Discussionmentioning

confidence: 99%

Higher Working Memory Predicts Slower Functional Decline in Autopsy-Confirmed Alzheimer's Disease

Pillai

Bonner‐Jackson

Walker³

et al. 2014

Dement Geriatr Cogn Disord

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Background: There is heterogeneity in the pattern of early cognitive deficits in Alzheimer's disease (AD). However, whether the severity of initial cognitive deficits relates to different clinical trajectories of AD progression is unclear. Objective: To determine if deficits in specific cognitive domains at the initial visit relate to the rate of progression in clinical trajectories of AD dementia. Methods: 68 subjects from the National Alzheimer's Coordinating Center database who had autopsy-confirmed AD as the primary diagnosis and at least 3 serial assessments a year apart, with a Mini-Mental State Examination (MMSE) score >15 and a Clinical Dementia Rating Scale-Global (CDR-G) score ≤1 at the initial visit were included. A mixed regression model was used to examine the association between initial neuropsychological performance and rate of change on the MMSE and CDR Sum of Boxes. Results: Preservation of working memory, but not episodic memory, in the mild cognitive impairment and early dementia stages of AD relates to slower rate of functional decline. Discussion: These findings are relevant for estimating the rate of decline in AD clinical trials and in counseling patients and families. Improving working memory performance as a possible avenue to decrease the rate of functional decline in AD dementia warrants closer investigation.

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Section: Discussionmentioning

confidence: 99%

Higher Working Memory Predicts Slower Functional Decline in Autopsy-Confirmed Alzheimer's Disease

Pillai

Bonner‐Jackson

Walker³

et al. 2014

Dement Geriatr Cogn Disord

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“…The Digit Span consists of two subtests: Forward and Backward. The Forward subtest is used to determine simple attention, whereas the Backward subtest relies more on complex attention, in which working memory and executive function are highly associated (Miloyan et al, 2013 ). A higher Digit Span score indicates better attention performance.…”

Section: Methodsmentioning

confidence: 99%

Attention and Functional Connectivity Among Patients With Early-Stage Subcortical Ischemic Vascular Disease and Alzheimer’s Disease

Hsu

Yang

et al. 2020

Front. Aging Neurosci.

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The current study compared attention profiles and functional connectivity of frontal regions in patients with early-stage subcortical ischemic vascular disease (SIVD) and Alzheimer's disease (AD). Twenty patients with SIVD, 32 patients with AD, and 23 subjects with normal cognition (NC) received cognition and resting-state functional MRI (rs-fMRI) evaluations. The Cognitive Abilities Screening Instrument (CASI) was used to assess global cognition, and simple attention, processing speed, divided attention, and vigilance/sustained attention were evaluated using the Digit Span Forward, Trail Making Test, Symbol Digit Modality Test, and Conners Continuous Performance Test, respectively. Voxel-based regional homogeneity (ReHo) derived from rs-fMRI data was analyzed to identify significant clusters, which were further correlated with attention profiles. Although the patients with SIVD and AD had comparable global cognitive ability, those with SIVD exhibited worse divided attention and vigilance/sustained attention than those with AD. Compared with the NC group, the patients with SIVD exhibited decreased ReHo within the right middle frontal gyrus (MFG) and left anterior cingulate gyrus (ACG), whereas the patients with AD exhibited increased ReHo within the right orbital part of frontal regions. Correlations between these three clusters with attention exhibited distinct patterns according to the dementia subtype, as did attention indices with significance in predicting global cognition. In summary, our study suggested that worse attention performance was associated with functional disconnection within the frontal regions among patients with SIVD than in those with AD. Frontal functional disconnection may underlie the pathogenesis responsible for defective divided attention, vigilance/sustained attention, and notable within-group variations identified in SIVD.

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“…Recently some effort has been exerted in assessing the degree to which attention issues contribute to cognitive decline in AD. Impaired attention in individuals with AD is associated with worsened performance on activities of daily living, and thus greatly affects the psychosocial impact of the disease (Miloyan et al, 2013). (Bracco et al, 2014) showed that treatment with cholinesterase inhibitors stabilized attention performance in individuals with AD, while memory performance continued to decline.…”

Section: Cholinergic Circuit Alterations In Cognitive Declinementioning

confidence: 99%

Basal Forebrain Cholinergic Circuits and Signaling in Cognition and Cognitive Decline

Ballinger

Ananth

Talmage

et al. 2016

Neuron

585

561

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Recent work continues to place cholinergic circuits at center stage for normal executive and mnemonic functioning, and provides compelling evidence that the loss of cholinergic signaling and cognitive decline are inextricably linked. This review focuses on the last few years of studies on the mechanisms by which cholinergic signaling contributes to circuit activity related to cognition. We attempt to identify areas of controversy, as well as consensus, on what is and is not yet known about how cholinergic signaling in the CNS contributes to normal cognitive processes. In addition, we delineate the findings from recent work on the extent to which dysfunction of cholinergic circuits contributes to cognitive decline associated with neurodegenerative disorders.

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Aspects of Attention Predict Real-World Task Performance in Alzheimer's Disease

Cited by 14 publications

References 54 publications

Higher Working Memory Predicts Slower Functional Decline in Autopsy-Confirmed Alzheimer's Disease

Higher Working Memory Predicts Slower Functional Decline in Autopsy-Confirmed Alzheimer's Disease

Attention and Functional Connectivity Among Patients With Early-Stage Subcortical Ischemic Vascular Disease and Alzheimer’s Disease

Basal Forebrain Cholinergic Circuits and Signaling in Cognition and Cognitive Decline

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