Aspects diagnostiques, thérapeutiques et pronostiques du diabète gestationnel au Centre Hospitalier Universitaire Sylvanus Olympio

Djagadou, K.A.; Tchamdja, Toyi; Nemi, Komi Dzidzonu; Balaka, Abago; Djibril, Mohaman Awalou

doi:10.11604/pamj.2019.34.18.18917

Cited by 3 publications

(9 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The observation that pregnant women with GDM tended to be younger is in line with the observation of Orru MI et al who, speaking of gestational pre-diabetes, had observed that relatively younger pregnant women were also affected and this should not exclude them from screening for GDM [2]. The age level of the pregnant women in this study is comparable to that done by Kodjo Agbeko and by Leye A. who respectively observed mean ages of 30.84 ± 4.17 years [16] and 29.8 ± 6.2 years [9]. The observation on this level of young age differs from those of most authors such as Tandu-Umba in Kinshasa [14], Tieu J [17] and Diane Farrar [4], who had observed that advanced age was a risk factor for eligibility for selective GDM screening.…”

Section: Discussionsupporting

confidence: 91%

Prevalence of gestational diabetes in Eastern Democratic Republic of Congo

Kisindja

Tugirimana

Prudence³

et al. 2022

BMC Pregnancy Childbirth

View full text Add to dashboard Cite

Objective To determine the prevalence of gestational diabetes and associated risk factors in the eastern region of the Democratic Republic of Congo (DRC). Methods A cross-sectional study was conducted in Goma city, Idjwi, Ngungu and Rutshuru districts between April 2019 and February 2021. Pregnant women between 24–28 weeks of amenorrhea who consented to participate in the study were included. Blood sugar, anthropometric parameters and obstetrical and family history were studied. Gestational diabetes was defined as blood glucose level between 92 and 125 mg/dL. Results The overall prevalence was 21.2% (n = 391) and was higher in Rutshuru [27.2% (n = 92)] and Goma [26.9% (n = 134)] compared to Ngungu [10.0% (n = 110)] (p = 0.005). An increased risk was associated with a history of a newborn weighing ≥ 4000 g [OR 2.4 95% CI (1.3 – 4.4)] or family diabetes [OR 2.9 95% CI (2.0 – 4.9)]. Median age in the pathological group was not different from that with normal blood glucose [25.0 (16.0 – 44.0) Vs 26.0 (16.0 – 44.0)] (p = 0.67). The prevalence tended to increase for pregnant women with a mid-upper arm circumference ≥ 280 mm [28.1% (n = 57)] Vs [19.3% (n = 322)] if < 280 mm, [OR (95% CI)] [1.5 (0.9—2.3)] (p = 0.13). Conclusion Gestational diabetes was found in one out of five pregnant women regardless their age. A history of macrosomia birth and diabetes in the family were the main risk factors.

show abstract

Section: Discussionsupporting

confidence: 91%

Prevalence of gestational diabetes in Eastern Democratic Republic of Congo

Kisindja

Tugirimana

Prudence³

et al. 2022

BMC Pregnancy Childbirth

View full text Add to dashboard Cite

show abstract

“…Among 25 women with GDM, 12 (48%) had a history of miscarriages and 4 (16%) had gone through preterm birth. Similar results have been reported by Djagadou et al [35], who showed that women with gestational diabetes had more frequently a history of spontaneous miscarriages and premature birth compared to control women. In the present study, most of those diagnosed with gestational diabetes were aged between 30 and 40 years.…”

Section: Discussionsupporting

confidence: 90%

“…Consequently, two experimental groups of subjects were then established: a group of women positive for GDM and a group of women negative for GDM considered as the control group. Then, twenty-five (25) women with GDM and thirty-five (35) age-matched and body mass index-matched pregnant controls were selected and submitted for blood collection and biochemical and immunological assays.…”

Section: Screening Of Gestational Diabetes Mellitusmentioning

confidence: 99%

Predictive Value of Immunological Parameters in the Risk of Gestational Diabetes Mellitus: A Pilot Study

Fagninou

Nekoua

Fiogbe

et al. 2020

Preprint

View full text Add to dashboard Cite

Background : Immunological and biochemical parameters are gaining more and more importance in the prognosis of diabetes and its complications. Here we assessed the predictive power of immunological parameters correlated with biochemical ones in gestational diabetes mellitus (GDM). Material and Methods : 217 pregnant women were screened for GDM between the 2 nd and the 3 rd trimester of gestation, based on IAGDP methods in this cross-sectional descriptive study. Immunological and biochemical parameters were determined using appropriate methods. Receiver operating characteristics (ROC) curve analyses were conducted to assess the optimal cutoff and value of immunological to biochemical parameter ratios for predicting GDM. Results : 11.90% of pregnant women were diagnosed GDM positive. Serum glucose levels, total cholesterol, LDL-cholesterol, triglycerides and total proteins were significantly increased while HDL-cholesterol decreased in women with GDM compared to controls. The levels of glycosylated hemoglobin and creatinine, as well as transaminase (AST and ALT) activities did not significantly differ between GDM and pregnant controls. Total leucocytes (white blood cell), lymphocyte and platelet numbers were significantly higher in women with GDM than in pregnant controls. We also found that the lymphocyte:HDL-C, monocyte:HDL-C and granulocyte:HDL-C ratios were significantly higher in women with GDM than in pregnant controls ( p = 0.001; p = 0.009 and p = 0.004 respectively). Women with a lymphocyte:HDL-C ratio greater than 3.66 had a 4-fold increased risk of developing GDM than those with lower ratios (odds ratio 4.00; 95% CI: 1.094 – 14.630; p =0.041). Conclusion : The lymphocyte:HDL-C, monocyte:HDL-C and granulocyte:HDL-C ratios may represent valuable makers, and the lymphocyte:HDL-C ratio in particular may have strong predictive power for GDM. This ratio can be easily assessed in patients.

show abstract

“…There is a positive, linear correlation with no real threshold between the risk of pregnancy complications and maternal blood glucose, raising the problem of diagnostic criteria for GDM [3] . Regardless of the type of GDM, it is a metabolic and obstetrical emergency [4] . GDM results in hyperglycemia of varying severity and can be the cause of maternal and/or fetal complications (pre-eclampsia, cesarean section, macrosomia) warranting optimal multidisciplinary management [2,4,5] .…”

Section: Introductionmentioning

confidence: 99%

“…Regardless of the type of GDM, it is a metabolic and obstetrical emergency [4] . GDM results in hyperglycemia of varying severity and can be the cause of maternal and/or fetal complications (pre-eclampsia, cesarean section, macrosomia) warranting optimal multidisciplinary management [2,4,5] . It is recognized that GDM increases the risk of preeclampsia and cesarean section in the absence of treatment [3] .…”

Section: Introductionmentioning

confidence: 99%

Gestational diabetes in urban Guinea: Results of a systematic screening

Bah¹,

Diallo²,

Bah³

et al. 2022

Int. J. Clin. Obstet. Gynaecol.

View full text Add to dashboard Cite

The prevalence of type 2 diabetes and moderate fasting hyperglycemia is high in Guinea, while data on gestational diabetes are scarce. Objective: To determine the prevalence of Gestational Diabetes among women admitted for prenatal consultation, identify their socio-epidemiological characteristics and any associated risk factors. Patients and Methods: Prospective study conducted in pregnant women who came for prenatal follow-up in two urban health centers in the prefecture of Kindia, Guinea during the period from January 1 to June 30, 2018, screened according to the recommendations of International Association of Diabetes and Pregnancy Study Group (IADPSG). A single abnormal value is sufficient to make the diagnosis of GDM. All pregnant women between 24 and 28 SA were included. Women with multiple pregnancies and/or preexisting diabetes or refusal to participate in the study were excluded. The variables analyzed: maternal age, gestational age, parity and exposure or not to risk factors. The data were analyzed by specific statistical tests with a probability p<0.05. Results: Seven hundred and forty-two (742) pregnant women were screened with 103 cases of GDM diagnosed, representing a prevalence of 13.8%. The epidemiological profile of women with GDM was dominated by the average maternal age which was 28.7 ± 6.5 years, housewives 57.28% (59/103), no level of education 53.39% (55/ 103), married 67.96% (70/103) with an average parity of 2.11± 1.9. The average gestational age was 27.1 ± 5.6 SA. The risk factors were dominated by advanced maternal age, with a proportion of 70.27% and 13.41% of patients without risk factors, screening for GDM was positive (P < 0.000001). Conclusion:The GDM is frequent among the women followed at the prenatal consultation in Kindia. Systematic screening integrated with prenatal care remains the best means of prevention.

show abstract

Aspects diagnostiques, thérapeutiques et pronostiques du diabète gestationnel au Centre Hospitalier Universitaire Sylvanus Olympio

Cited by 3 publications

References 7 publications

Prevalence of gestational diabetes in Eastern Democratic Republic of Congo

Prevalence of gestational diabetes in Eastern Democratic Republic of Congo

Predictive Value of Immunological Parameters in the Risk of Gestational Diabetes Mellitus: A Pilot Study

Gestational diabetes in urban Guinea: Results of a systematic screening

Contact Info

Product

Resources

About