Aspects cliniques et facteurs pronostiques des leptospiroses ictéro-hémorragiques de l'adulte

Pertuiset, Édouard; Chong, Miguel; Duval, G.; Genin, R

doi:10.1016/s0248-8663(88)80012-2

Cited by 21 publications

(15 citation statements)

References 27 publications

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“…Cardisc complications have been less frequently reported (PERTUISET et al, 1988;EVERARD et al. 1995) but cardiac involvement has not been always actively looked after.…”

Section: Discussionmentioning

confidence: 99%

Pulmonary haemorrhage as a predominant cause of death in leptospirosis in Seychelles

Yersin

Bovet

Mérien

et al. 2000

Transactions of the Royal Society of Tropical Medicine and Hygi

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We examined the cause of death during a 12-month period (1995196) in all consecutive patients admitted to hospital with leptospiral infection in Seychelles (Indian Ocean), where the disease is endemic. Leptospirosis was diagnosed by use of the microscopic agglutination test and a specific polymerase chain reaction assay on serum samples. Seventy-five cases were diagnosed and 6 patients died, a case fatality of 8%. All 6 patients died within 9 days of onset of symptoms and within 2 days of admission for 5 of them (5 days for the 6th). On autopsy, diffuse bilateral pulmonary haemorrhage (PH) was found in all fatalities. Renal, cardiac, digestive and cerebral haemorrhages were also found in 5,3,3 and 1 case(s), respectively. Incidentally, haemoptysis and lung infiltrate on chest radiographs, which suggest PH, were found in 8 of the 69 non-fatal cases. Dengue and hantavirus infections were ruled out. In conclusion, PH appeared to be a main cause of death in leptospirosis in this population, although haemorrhage in other organs may also have contributed to fatal outcomes. This cause of death contrasts with the findings generally reported in endemic settings.

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“…Cardisc complications have been less frequently reported (PERTUISET et al, 1988;EVERARD et al. 1995) but cardiac involvement has not been always actively looked after.…”

Section: Discussionmentioning

confidence: 99%

Pulmonary haemorrhage as a predominant cause of death in leptospirosis in Seychelles

Yersin

Bovet

Mérien

et al. 2000

Transactions of the Royal Society of Tropical Medicine and Hygi

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“…Pulmonary involvement has been found to be consistently associated with mortality in multiple studies conducted. Perusitat, 16 Budiono 17 and Dupont 18 report that radiographical evidence of pulmonary involvement was associated with mortality. Budiono 17 found that pulmonary involvement was the strongest risk factor associated with mortality.…”

Section: Factors Associated With Mortalitymentioning

confidence: 99%

Determinants of mortality and impact of therapy in patients with leptospirosis admitted for intensive care in a Sri Lankan hospital – a three year retrospective study

Weeratunga

Fernando

Sriharan

et al. 2015

Pathogens and Global Health

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“…Human infections primarily result from the Leptospira interrogans serogroup Icterohaemorrhagiae, which is responsible for many severe forms [12]. From 1966 to 2003, the L. interrogans serogroup Icterohaemorrhagiae accounted for 70% to 83% of all hospitalized cases [13].…”

Section: Introductionmentioning

confidence: 99%

Human Leptospirosis on Reunion Island: Past and Current Burden

Pagès

Polycarpe²,

Dehecq³

et al. 2014

IJERPH

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Since 1953, leptospirosis has been recognized as a public health problem on Reunion Island. In 2004, was implemented a specific surveillance system that included systematic reporting and the realization of environmental investigations around hospitalized cases. Here, we present the synthesis of historical data and the assessment of 9 years of leptospirosis surveillance. From 2004 to 2012, 414 hospitalized cases were reported. Cases of leptospirosis occurred mostly during the rainy season from December to May. Approximately 41% of infections occurred at home, 12% of infections occurred during aquatic leisure and 5% of cases were linked to professional activities. Furthermore, for 41% of cases, the place of infection could not be determined due to the accumulation of residential and non-residential exposure. Most of the cases of leptospirosis were linked to rural areas or traditional, rural occupations. We did not observe a shift to recreational leptospirosis as described in some developed countries. According to the new surveillance system, the number of reported cases has regularly increased since 2004. This situation is in part due to the improvement of the system in the first years but also to a real increase in the number of detected cases due to the introduction of molecular methods and to increased biological investigation into the Dengue-like syndrome by medical practitioners on the island since the Chikungunya crisis in 2006. This increase is probably due to surveillance and diagnosis biases but need to be carefully monitored. Nevertheless, the possibility of an outbreak is always present due to climatic events, such as after the “hyacinth” hurricane in 1980.

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Aspects cliniques et facteurs pronostiques des leptospiroses ictéro-hémorragiques de l'adulte

Cited by 21 publications

References 27 publications

Pulmonary haemorrhage as a predominant cause of death in leptospirosis in Seychelles

Pulmonary haemorrhage as a predominant cause of death in leptospirosis in Seychelles

Determinants of mortality and impact of therapy in patients with leptospirosis admitted for intensive care in a Sri Lankan hospital – a three year retrospective study

Human Leptospirosis on Reunion Island: Past and Current Burden

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