Aspectos neuropsicológicos do transtorno afetivo bipolar

Malloy-Diniz, Leandro Fernandes; Neves, Fernando Silva; Corrêa, Humberto

doi:10.1590/s1516-44462009000200018

Cited by 2 publications

(1 citation statement)

References 4 publications

(3 reference statements)

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“…b -As funções executivas correspondem a um conjunto de habilidades que permitem ao indivíduo direcionar comportamentos às metas, avaliar a eficiências e adequação desses comportamentos, abandonarem estratégias erradas e resolver problemas (7).…”

Section: Funções Executivasunclassified

Atenção e funções executivas: funções neuropsicológicas alteradas no TDAH

Simão,

Ciasca

2012

Debates em Psiquiatria

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Como funções neuropsicológicas a atenção e as funções executivas possuem grande importância para que a capacidade de aprendizagem não seja prejudicada, como também são funções que se apresentam alteradas no quadro do Transtorno de Déficit de Atenção e Hiperatividade, uma vez que a atenção é definida como a capacidade de selecionar e manter os estímulos adequados para atividade e as funções executivas são capacidade de organizar, planejar e executar a atividade, capacidades estas prejudicadas em uma criança com o diagnóstico de TDAH.

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Section: Funções Executivasunclassified

Atenção e funções executivas: funções neuropsicológicas alteradas no TDAH

Simão,

Ciasca

2012

Debates em Psiquiatria

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The relationship between the Met allele of the BDNF Val66Met polymorphism and impairments in decision making under ambiguity in patients with obsessive-compulsive disorder

Rocha¹,

Malloy-Diniz²,

Lage³

et al. 2011

Genes, Brain and Behavior

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Brain-derived neurotrophic factor (BDNF) gene has an important link to neurotransmitter systems, including serotonin, and seems to play a major role in emotional decision making. Impairment of decision making is an important feature of psychiatric disorders such as obsessive-compulsive disorder (OCD). We explore the link between decision making and the BDNF Val66Met polymorphism, which results in a reduction of BDNF activity, in a sample of Caucasian OCD patients. We used the Iowa Gambling Task (IGT) to measure decision making in 122 OCD patients. All patients were assessed using the Yale-Brown Obsessive-Compulsive Scale, the Beck Depression Inventory, the Beck Anxiety Inventory and the Raven Progressive Matrices. Patients also performed the Continuous Performance Task (CPT-II) and the Trail Making Test (TMT). We grouped Met-allele carriers because these act in a dominant way. Metallele carries exhibited low performance on both halves of the IGT (first half -F = −2.51, df = 120, P = 0.01; second half -F = −2.32, df = 120, P = 0.02). However, logistic regression analyses showed that the influence of the Met allele seemed to be restricted to the first half of the IGT [first half -β = 0.55, df = 1, P < 0.01, odds ratio (OR) = 5.62; second half -β = 0.32, df = 1, P = 0.15, OR = 2.30]. No differences were observed in tests used to evaluate executive functions associated with the dorsolateral prefrontal cortices (TMT and CPT-II, df = 120, P > 0.05 for both). Met-allele impairment may only be related to decisions made under ambiguous conditions. The null results involving TMT and CPT-II are possibly related to the dysfunction of the orbitofrontal cortices that is associated with OCD.

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Aspectos neuropsicológicos do transtorno afetivo bipolar

Cited by 2 publications

References 4 publications

Atenção e funções executivas: funções neuropsicológicas alteradas no TDAH

Atenção e funções executivas: funções neuropsicológicas alteradas no TDAH

The relationship between the Met allele of the BDNF Val66Met polymorphism and impairments in decision making under ambiguity in patients with obsessive-compulsive disorder

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