Aspectos actuales de las enfermedades invasivas por hongos filamentosos

Pemán, Javier; Quindós, Guillermo

doi:10.1016/j.riam.2014.07.003

Revista Iberoamericana de Micología

2014

DOI: 10.1016/j.riam.2014.07.003

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Aspectos actuales de las enfermedades invasivas por hongos filamentosos

Javier Pemán

Guillermo Quindós

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Cited by 6 publications

(1 citation statement)

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“…AML: Acute myeloid leukemia; ANC: absolute neutrophil count; CGD: Chronic granulomatous disease; COPD: Chronic obstructive pulmonary disease; GVHD, graft versus host disease; HIV: Human immunodeficiency virus; HSCT: Hematopoietic stem-cell transplantation; IA: invasive aspergillosis; MDS: Myelodysplastic syndrome; SOTR: Solid Organ Transplant Recipient. Adapted from: Pemán J et al37 proven or probable IA were included). The authors established that the risk factors present that favored the develop-…”

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confidence: 99%

Section 1. Colombian consensus on the diagnosis and follow-up of invasive aspergillosis and Aspergillus disease in adult and pediatric patients

Rivas-Pinedo

Oñate

Berrío

et al. 2022

Infect

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For a long time, the diagnostic approach to IA/Aspergillus disease has been a challenge. The definitive diagnosis is made by correct microbiological and/or histopathological documentation, undoubtedly the fundamental cornerstone for therapeutic decision-making. However, it is considered limited by lack of sensitivity and speed, often being counterproductive, as in many cases invasive procedures are needed (e.g., fibrobronchoscopy [FBC] or tissue biopsy), which delays treatment and undermines survival of at-risk patients. This highlights the need for faster and more accurate diagnostic tools. Although novel serological and molecular methods have been developed that have demonstrated their potential to replace conventional diagnostic tests, inconsistencies in interpretation and validation among the different approaches limit their reproducibility and large-scale clinical application. However, whenever possible, an immunological and/or molecular diagnosis should be made, as it has proven useful in different detection and diagnostic strategies, which with an understanding of its strengths and limitations, and the standardization of the different techniques available, can be incorporated into care protocols and diagnostic algorithms, as an aid in administering and monitoring the different antifungal treatments and predicting possible clinical outcomes. Due to the limited sensitivity (SE) of many of the tests, and variations in the specificity (SP) of some of them, the combined use of several diagnostic tools during the high-risk period for invasive infection and/or during the early period in the course of IA/Aspergillus disease would allow an adequate diagnostic approach, provided that their results are interpreted together with the existing clinical and imaging information.

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mentioning

confidence: 99%

Section 1. Colombian consensus on the diagnosis and follow-up of invasive aspergillosis and Aspergillus disease in adult and pediatric patients

Rivas-Pinedo

Oñate

Berrío

et al. 2022

Infect

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MALDI-TOF MS: Foundations and a Practical Approach to the Clinically Relevant Filamentous Fungi Identification

Gómez-Velásquez¹,

Mojica-Figueroa²,

Santos

et al. 2021

Curr Fungal Infect Rep

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Espectrometría de masas MALDI-TOF: evaluación de la etapa preanalítica para la identificación de hongos miceliales

Maldonado

Ramírez

Striebeck

et al. 2017

Revista Argentina de Microbiología

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In order to optimize the identification of molds with MALDI-TOF MS, three protein extraction-methodologies were evaluated against 44 isolates: water extraction (WE), zirconium extraction (ZE) and the provider's recommended method (PRM). Two data bases were compared, Bruker (BK) and Bruker+National Institutes of Health. Considering both databases, results were respectively as follows: correct identification (CI) at gender level, 10 and 16 by WE; 27 and 32 by ZE and 18 and 23 by PRM; CI at species level, 5 and 7 by WE; 17 and 20 by ZE and 11 and 14 by PRM; non-reliable identification, 18 and 12 by WE; 9 and 4 by ZE and by PRM. No peaks were observed in 16 by WE, 8 by ZE and 17 by PRM. ZE showed the best perfomance (p<0.05).

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Aspectos actuales de las enfermedades invasivas por hongos filamentosos

Cited by 6 publications

References 38 publications

Section 1. Colombian consensus on the diagnosis and follow-up of invasive aspergillosis and Aspergillus disease in adult and pediatric patients

Section 1. Colombian consensus on the diagnosis and follow-up of invasive aspergillosis and Aspergillus disease in adult and pediatric patients

MALDI-TOF MS: Foundations and a Practical Approach to the Clinically Relevant Filamentous Fungi Identification

Espectrometría de masas MALDI-TOF: evaluación de la etapa preanalítica para la identificación de hongos miceliales

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