Aspartic acid tagged carbon nanotubols as a tool to deliver docetaxel to breast cancer cells: Reduced hemotoxicity with improved cytotoxicity

Thotakura, Nagarani; Sharma, Saurabh; Khurana, Rajneet Kaur; Babu, Penke Vijaya; Kumar, Vipin; Singh, Bhupinder; Raza, Kaisar

doi:10.1016/j.tiv.2019.04.012

Cited by 17 publications

(5 citation statements)

References 36 publications

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“…Various materials, including polymers such as polyacrylate and polyvinyl; polyethylene glycol (PEG), polysorbates, polysaccharides, polysilicones, and polyamino acids of varying molecular weight, and various polypeptides, are used as thickeners, feel enhancers, and emulsifiers. Aspartic acid was found to be more effective than general drug in the preparation of nanoconjugate with anticancer agent and it was confirmed that the same result was obtained in the experiment using polyaspartic acid [1,2].…”

Section: Introductionsupporting

confidence: 74%

New Anti-Aging and Anti-Wrinkle Material: Properties and Activities of Nanoparticle Containing Poly(Aspartic Acid) Derivatives

Kim

et al. 2019

JNanoR

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Polymers such as sodium polyacrylate; polysaccharides in starch; polyamino acids, which are the products of alpha-amino acid condensation; and polypeptides are widely used in cosmetics and pharmaceuticals. They are used as viscosity agent, emulsifying agent, and carriers for drug delivery. However, we studied the function of polymers as activity agent, especially that of synthesized poly(aspartic acid). Poly(aspartic acid) is a biocompatible synthetic polymer. It is a water-soluble polyamide containing carboxylic pendants prepared from polysuccinimide, the polycondensate of aspartic acid monomer, by hydrolysis. In this study, we prepared poly(aspartic acid) derivatives conjugated with L-lysine or L-lysine and other materials. The chemical structure of these polymers was confirmed by FT-IR and 1H-NMR spectroscopy. Moreover, these novel poly(aspartic acid) derivatives stimulated typeⅠcollagen biosynthesis and inhibited MMP-1(collagenase) activity. We could conclude that the microfludization process improved skin permeability and confirmed better permeability than that achieved with existing nano emulsions.

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Section: Introductionsupporting

confidence: 74%

New Anti-Aging and Anti-Wrinkle Material: Properties and Activities of Nanoparticle Containing Poly(Aspartic Acid) Derivatives

Kim

et al. 2019

JNanoR

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“…This study offered better hope for the development of a promising therapy with lower systemic toxicity that might be utilized for tumor treatments in the future. Similarly, CNMs in conjugation with other anticancer drugs, such as docetaxel [88], tamoxifen [89], and oxaliplatin [90] have also shown encouraging results for the treatment of cancer in vitro, as well as in the in vivo study. Table 2 emphasizes different types of drug-loaded CNMs studied for the assessment of efficacy in vitro and in vivo against several diseases.…”

Section: Drug Delivery Systemsmentioning

confidence: 99%

Biomedical Applications of Carbon Nanomaterials: Fullerenes, Quantum Dots, Nanotubes, Nanofibers, and Graphene

et al. 2021

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Carbon nanomaterials (CNMs) have received tremendous interest in the area of nanotechnology due to their unique properties and flexible dimensional structure. CNMs have excellent electrical, thermal, and optical properties that make them promising materials for drug delivery, bioimaging, biosensing, and tissue engineering applications. Currently, there are many types of CNMs, such as quantum dots, nanotubes, nanosheets, and nanoribbons; and there are many others in development that promise exciting applications in the future. The surface functionalization of CNMs modifies their chemical and physical properties, which enhances their drug loading/release capacity, their ability to target drug delivery to specific sites, and their dispersibility and suitability in biological systems. Thus, CNMs have been effectively used in different biomedical systems. This review explores the unique physical, chemical, and biological properties that allow CNMs to improve on the state of the art materials currently used in different biomedical applications. The discussion also embraces the emerging biomedical applications of CNMs, including targeted drug delivery, medical implants, tissue engineering, wound healing, biosensing, bioimaging, vaccination, and photodynamic therapy.

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“…The results were in concurrence with the previously published reports on the analysis and quantification of docetaxel in various systems. The findings were satisfactory and inferred the chances of better quantification of the drugs from various media and solvents systems [18,28,29,30].…”

Section: High Performance Liquid Chromatography (Hplc)mentioning

confidence: 99%

Preparation and Characterization of Novel Anti-cancer drug (s) loaded Co-crystals

Manju¹,

Jalwal²,

Rathi³

et al. 2021

JUSST

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Background: Taxanes constitute an important class of anti-cancer agents, which are widely prescribed for the management of cancers like breast, lung and ovaries. These agents belong to Biopharmaceutical Classification System (BCS) class IV, which are neither soluble in the aqueous systems nor permeable across the biological membranes. Objectve: Due to these concerns only, the oral bioavailabilities of these drugs are too low. Looking into these concerns, it was envisaged to develop co-crystals of docetaxel with syringic acid. Methods: For the preparation of co-crystals no single method is used. The methods range from spray drying, crystallization, ultrasonication and freeze drying to supercritical fluid methodologies. Results: The novel co-crystal not only improved the solubility and dissolution rates of the drug, but also resulted in improved pharmacokinetic profile. Conclusion: The present findings provide an economic and viable approach to improve the solubility and absorption profile of a drug, which is a vital component of the anticancer chemotherapy. Such studies provide a hope for the development of approaches to improve the solubility and permeability of drugs with challenges.

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Aspartic acid tagged carbon nanotubols as a tool to deliver docetaxel to breast cancer cells: Reduced hemotoxicity with improved cytotoxicity

Cited by 17 publications

References 36 publications

New Anti-Aging and Anti-Wrinkle Material: Properties and Activities of Nanoparticle Containing Poly(Aspartic Acid) Derivatives

New Anti-Aging and Anti-Wrinkle Material: Properties and Activities of Nanoparticle Containing Poly(Aspartic Acid) Derivatives

Biomedical Applications of Carbon Nanomaterials: Fullerenes, Quantum Dots, Nanotubes, Nanofibers, and Graphene

Preparation and Characterization of Novel Anti-cancer drug (s) loaded Co-crystals

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