Aspartate aminotransferase to platelet ratio index (APRI) score: is it useful in patients with intrahepatic cholestasis of pregnancy?

Eyisoy, Ömer Gökhan; Taşdemir, Ümit; Özdemir, Mucize Eriç; Eyisoy, Seden; Kahramanoğlu, Özge; Öçal, Aydın; Demirci, Oya

doi:10.1080/14767058.2022.2122036

Cited by 5 publications

(6 citation statements)

References 21 publications

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“…The study also showed a significant positive association between the APRI score and fasting bile acid level. Similar to our study, they found that higher APRI scores were associated with meconium‐stained amniotic fluid, NICU admission, and preterm delivery 20 …”

Section: Discussionsupporting

confidence: 90%

“…APRI scores in the ICP group were correlated with composite adverse outcomes. These results were compatible with previous studies 18–20 . However, higher composite adverse outcomes in the severe ICP group than in the mild ICP group and a correlation between APRI scores and serum bile acid levels could not be documented.…”

Section: Discussionsupporting

confidence: 90%

“…Similar to our study, they found that higher APRI scores were associated with meconium-stained amniotic fluid, NICU admission, and preterm delivery. 20 In the current study, patients with ICP were shown to have a higher risk for adverse perinatal outcomes. APRI scores during the whole pregnancy were significantly higher in patients with ICP.…”

Section: Cs Indications N (%)mentioning

confidence: 62%

“…These results were compatible with previous studies. [18][19][20] However, higher composite adverse outcomes in the severe ICP group than in the mild ICP group and a correlation between APRI scores and serum bile acid levels could not be documented. This may be interpreted as composite adverse outcomes being seen in cases with lower serum bile acid levels.…”

Section: Cs Indications N (%)mentioning

confidence: 92%

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Role of aspartate aminotransferase to platelet ratio in the prediction and prognosis of intrahepatic cholestasis of pregnancy: A case–control study from a tertiary center

Peker

İpek

Ağaoğlu

et al. 2023

Intl J Gynecology & Obste

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ObjectiveTo evaluate the aspartate aminotransferase to platelet ratio (APRI) score as a predictive and prognostic test in intrahepatic cholestasis of pregnancy (ICP).MethodsThis study was conducted in 198 patients diagnosed with ICP and 204 healthy pregnant women who presented to a tertiary center between 2019 and 2022. APRI scores; laboratory findings in the first, second, and third trimesters; and perinatal outcomes were compared between the two groups. The ICP group was evaluated for correlation between APRI scores and composite adverse outcomes. Two different receiver operating characteristic analyses were performed to determine optimal cutoff values of predictive APRI score of ICP and composite adverse outcomes in patients with ICP.ResultsAspartate aminotransferase values and APRI scores were significantly higher in the ICP group in all trimesters (P < 0.001). The optimal cutoff values of APRI scores to predict ICP for the first, second, and third trimesters were 0.101 (79.7% sensitivity, 79.6% specificity), 0.103 (78.4% sensitivity, 76.3% specificity), and 0.098 (72.5% sensitivity, 72% specificity), respectively. APRI scores were statistically higher in patients with ICP with composite adverse outcomes in all trimesters (P values of 0.03, 0.04, and 0.01, respectively).ConclusionAPRI score was found to be a valuable predictor of ICP and its adverse outcomes during the entire pregnancy.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionsupporting

confidence: 90%

Section: Cs Indications N (%)mentioning

confidence: 62%

Section: Cs Indications N (%)mentioning

confidence: 92%

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Role of aspartate aminotransferase to platelet ratio in the prediction and prognosis of intrahepatic cholestasis of pregnancy: A case–control study from a tertiary center

Peker

İpek

Ağaoğlu

et al. 2023

Intl J Gynecology & Obste

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“…Particularly, this index has the advantage of including only two common and inexpensive markers: namely, AST and platelet count laboratory tests. The APRI score has been shown to possess a predictive value for conditions such as HELLP (hemolysis, elevated liver enzyme levels, low platelet counts) syndrome and cholestasis [ 22 , 23 ]. While others have used the GTT-to-platelet ratio (GPR) or ALP-to-platelet ratio (APPRI) as markers to predict liver fibrosis and cirrhosis in chronic hepatitis B and individuals with NAFLD [ 24 , 25 ], far less studies have tested the clinical utility of ALT instead of AST in calculating the APRI score index.…”

Section: Introductionmentioning

confidence: 99%

AST and ALT APRI Scores and Dysglycemia in Saudi Arabia: A Retrospective Population Study

Alshuweishi,

Alfaifi,

Almoghrabi

et al. 2023

Life

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Background: Hyperglycemia is a common symptom of numerous conditions, most notably diabetes mellitus and Cushing’s syndrome, and the liver plays a pivotal role in the regulation of glucose metabolism. The AST–platelet ratio index (AST APRI score) and ALT–platelet ratio index (ALT APRI score) are novel parameters whose association with circulating glucose levels remains poorly studied. Methods: Laboratory data of 14,177 subjects were retrospectively analyzed for the association between AST and ALT APRI scores and fasting blood glucose (FBG) using the Mann–Whitney U and Kruskal–Wallis tests, Spearman’s rank correlation coefficient, prevalence and odds ratio (OR) and ROC curve analysis. Results: AST and ALT APRI scores showed progressive increases with FBG, and the mean FBG was significantly higher in subjects with high AST (104.9 ± 0.33 to 120.8 ± 3.27, p < 0.0001) and ALT (104.7 ± 0.34 to 111.6 ± 1.30, p < 0.0001) APRI scores. However, the AST APRI score but not the ALT APRI score was affected by age and gender. Notably, both elevated AST and ALT APRI scores were more prevalent in hyperglycemic subjects irrespective of gender and were associated with FBG, albeit through mediator variables. Increased AST (OR = 2.55, 95% CI: 1.46–2.06, p < 0.0001) and ALT (OR = 1.73, 95% CI: 1.46–2.06, p < 0.0001) APRI scores carried a significantly higher risk for hyperglycemia. Importantly, the ALT APRI score was superior to that of the AST APRI score in distinguishing hyperglycemic subjects. Conclusions: The AST and ALT APRI scores are inexpensive, novel markers of FBG and may serve as supportive evidence in the diagnosis and management of hyperglycemic conditions.

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Assessment of aspartate aminotransferase to Platelet Ratio Index and Fibrosis-4 Index score on women with intrahepatic cholestasis of pregnancy

Cemortan,

Iliadi-Tulbure,

Sagaidac

et al. 2024

AJOG Global Reports

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Aspartate aminotransferase to platelet ratio index (APRI) score: is it useful in patients with intrahepatic cholestasis of pregnancy?

Cited by 5 publications

References 21 publications

Role of aspartate aminotransferase to platelet ratio in the prediction and prognosis of intrahepatic cholestasis of pregnancy: A case–control study from a tertiary center

Role of aspartate aminotransferase to platelet ratio in the prediction and prognosis of intrahepatic cholestasis of pregnancy: A case–control study from a tertiary center

AST and ALT APRI Scores and Dysglycemia in Saudi Arabia: A Retrospective Population Study

Assessment of aspartate aminotransferase to Platelet Ratio Index and Fibrosis-4 Index score on women with intrahepatic cholestasis of pregnancy

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