Aspartame supplementation in starter accelerates small intestinal epithelial cell cycle and stimulates secretion of glucagon‐like peptide‐2 in pre‐weaned lambs

Sun, Dongdong; Liu, Lixiang; Mao, Shengyong; Zhu, Weiyun; Liu, Junhua

doi:10.1111/jpn.13159

Cited by 5 publications

(2 citation statements)

References 37 publications

(61 reference statements)

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“…Sun et al, 2019 [58] In vivo and in vitro study on small intestinal cell cycle and stimulating secretion and expression of glucagon-like peptide-2 (GLP-2) in pre-weaned lambs Twelve 14-day lambs were randomly divided into two groups; control (n = 6) fed on starter food, and aspartame-fed (200 mg/kg) (n = 6) up to 49 days. At 56 days, 4 healthy lambs' jejunal tissue was used to dissociate and culture epithelial cells, treated with control, GLP-2 10 nM alone or with IGF-1R inhibitor picropodophyllin (PPP) 1 µM.…”

Section: Methods Experimental Groups Main Resultsmentioning

confidence: 99%

Aspartame Safety as a Food Sweetener and Related Health Hazards

Shaher,

Mihailescu,

Amuzescu

2023

Preprint

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Aspartame is the methyl-ester of the aspartate-phenylalanine dipeptide. Over time it became a very popular artificial sweetener. However, since its approval by the main food safety agencies, several concerns have been raised related to neuropsychiatric effects and neurotoxicity, due to its ability to activate glutamate receptors, as well as carcinogenic risks by increased production of reactive oxygen species. Within this review we critically evaluated reports concerning the safety of aspartame. Some studies evidenced subtle mood and behavioral changes upon daily high-dose intake below the admitted limit. Epidemiology studies also evidenced associations between daily aspartame intake and higher predisposition for malignant diseases like non-Hodgkin lymphomas and multiple myelomas, particularly in males, but association by chance still could not be excluded. While the debate over the carcinogenic risk of aspartame is ongoing, it is clear that its use may pose some dangers in peculiar cases, such as patients with seizures or other neurological diseases; it should be totally forbidden for patients with phenylketonuria, and reduced doses or complete avoidance are advisable during pregnancy. It would be also highly desirable for every product containing aspartame to clearly indicate on the label the exact amount of the substance and some risk warnings.

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Section: Methods Experimental Groups Main Resultsmentioning

confidence: 99%

Aspartame Safety as a Food Sweetener and Related Health Hazards

Shaher,

Mihailescu,

Amuzescu

2023

Preprint

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“… The induction of p-PPARγ, PPARγ, SREBP1, and adipsin (by Western blot) and PPARγ, FABP4, and C/EBPα (RT-qPCR) was significantly reduced in aspartame-treated preadipocytes, as well as lipid accumulation (by Oil Red O staining). Sun et al, 2019 [ 58 ] In vivo and in vitro study on small intestinal cell cycle and stimulating secretion and expression of glucagon-like peptide-2 (GLP-2) in pre-weaned lambs Twelve 14-day lambs were randomly divided into two groups; control ( n = 6) fed on starter food, and aspartame-fed (200 mg/kg) ( n = 6) up to 49 days. At 56 days, 4 healthy lambs’ jejunal tissue was used to dissociate and culture epithelial cells, treated with control, GLP-2 10 nM alone or with IGF-1R inhibitor picropodophyllin (PPP) 1 µM.…”

Section: Table A1mentioning

confidence: 99%

Aspartame Safety as a Food Sweetener and Related Health Hazards

Shaher,

Mihailescu,

Amuzescu

2023

Nutrients

View full text Add to dashboard Cite

Aspartame is the methyl-ester of the aspartate-phenylalanine dipeptide. Over time, it has become a very popular artificial sweetener. However, since its approval by the main food safety agencies, several concerns have been raised related to neuropsychiatric effects and neurotoxicity due to its ability to activate glutamate receptors, as well as carcinogenic risks due to the increased production of reactive oxygen species. Within this review, we critically evaluate reports concerning the safety of aspartame. Some studies evidenced subtle mood and behavioral changes upon daily high-dose intake below the admitted limit. Epidemiology studies also evidenced associations between daily aspartame intake and a higher predisposition for malignant diseases, like non-Hodgkin lymphomas and multiple myelomas, particularly in males, but an association by chance still could not be excluded. While the debate over the carcinogenic risk of aspartame is ongoing, it is clear that its use may pose some dangers in peculiar cases, such as patients with seizures or other neurological diseases; it should be totally forbidden for patients with phenylketonuria, and reduced doses or complete avoidance are advisable during pregnancy. It would be also highly desirable for every product containing aspartame to clearly indicate on the label the exact amount of the substance and some risk warnings.

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