Aspartame-Stabilized Gold–Silver Bimetallic Biocompatible Nanostructures with Plasmonic Photothermal Properties, Antibacterial Activity, and Long-Term Stability

Fasciani, Chiara; Silvero, María Jazmín; Anghel, M.; Argüello, Gustavo A.; Becerra, María Cecilia; Scaiano, Juan C.

doi:10.1021/ja510435u

Cited by 144 publications

(89 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[25][26][27][28] Au NPs have advantages of easy preparation, homogeneity and biocompatibility, but suffer from low antibacterial property. Madhuchanda Banerjee et al 29 fabricated bimetallic Au@Ag NPs with positive charges on the surface.…”

Section: -14mentioning

confidence: 99%

Shell thickness-dependent antibacterial activity and biocompatibility of gold@silver core–shell nanoparticles

et al. 2017

View full text Add to dashboard Cite

Antimicrobial activity of silver is highly effective and broad-spectrum; however, poor long-term antibacterial efficiency and cytotoxicity toward mammalian cells have restricted their applications. Here, we fabricated Au@Ag NPs with tailored shell thickness, and investigated their antibacterial activities against both Gram-negative bacteria (Escherichia coli) and Gram-positive bacteria (Staphylococcus aureus) and the cytotoxicity toward SH-SY5Y human cells, for the first time. Our results demonstrate that Au@Ag NPs with a thickness of 5 nm or Au : Ag ratio 1 : 1 (Au@Ag-2 NPs) have the highest antibacterial activity and excellent biocompatibility. The minimum inhibitory concentration (MIC) values of Au@Ag-2 NPs in terms of effective silver concentration are 5 mg mL À1 for E. coli and 7.5 mg mL À1 for S. aureus, IntroductionTo cope with the overwhelming challenges of infectious diseases resulting from pathogenic bacteria, nano-sized materials, emerging as new types of safe and cost-effective bactericidal materials, have been widely investigated. Among those numerous nanomaterials, silver nanoparticles (Ag NPs) are the most promising antibacterial agents because of their inherent properties of high thermal stability, limited microbial resistance, and broad-spectrum antimicrobial activity against bacteria, viruses and other eukaryotic microorganisms. 1-4 Sondi and co-workers 5 demonstrated that Ag NPs can easily adsorb to the membrane surface of bacteria through electrostatic interaction, form permeable pits, and cause an osmotic collapse in the cells. The other possible mechanism is the release of silver ions (Ag + ) from the oxidized Ag NPs. 6-8 Ag NPs are easy to oxidize and produce a high concentration of Ag + , the released Ag + then destroys the respiratory chain and leads to the formation of reactive oxygen species (ROS), such as hydroxyl radicals, H 2 O 2 and hydroperoxyl radicals, which nally trigger cell damage of the cellular components and leads to the death of the bacteria. 9-11 In spite of this, the easy oxidation of pure Ag NPs and the toxicity in mammalian cells remain challenges in Ag NP applications. 12-14To address this problem, Ag NPs have been decorated with other nanomaterials by the formation of nanostructures. Song et al. 15synthesized the silver/polyrhodanine compositedecorated silica nanoparticles, which exhibited excellent antimicrobial activity toward Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) because of the antibacterial effects of both the silver nanoparticles and the polyrhodanine. Tan et al. 16synthesized antibacterial Ag@dsDNA@GO, which can wrap around the Xanthomonas perforans cell and results in rapid cell apoptosis, showing the synergistic antibacterial effect. While these nanostructures can effectively enhance the antibacterial activity of Ag NPs, they oen require complex and tedious preparation methods, and suffering from low yields, poor longterm antibacterial activity, and biocompatibility problems. 17,18Bimetallic core-shell nanoparticles are graduall...

show abstract

Section: -14mentioning

confidence: 99%

Shell thickness-dependent antibacterial activity and biocompatibility of gold@silver core–shell nanoparticles

et al. 2017

View full text Add to dashboard Cite

show abstract

“…Fasciani et al have reported that the benzoyl radicals (BRs) under the air conditions are transferred to benzoyl-type acids (BAs). [22] Under the present reaction conditions (with traces of oxygen) the abrupt increase in the initial rate of polymerization might be somehow connected with the formation of peroxides via the excited benzoyl fragments and oxygen. Table 1 shows the weight, viscosity and number average molecular weights and the molecular weight distribution as a function of AAm concentration.…”

Section: Methodsmentioning

confidence: 69%

“…Photolysis and initiating radical formation: Darocur (Dar), ketyl radical (Kr), benzoyl radical (Br). [22] However, the abrupt decrease in the polymerization rate with conversion at the very low conversion range indicates that the k p /k t s are not able to explain this behavior. Thus, we should include other parameters such as the photoinitiator efficiency, average or local monomer comcentration and impurities.…”

Section: Methodsmentioning

confidence: 99%

Photopolymerization of acrylamide in the very low monomer concentration range

Capek

2016

Designed Monomers and Polymers

View full text Add to dashboard Cite

Photopolymerization of acrylamide in the very low monomer concentration rangeIgnác Capek slovak academy of sciences, Polymer institute, institute of Measurement sciences, Bratislava, slovakia ABSTRACTThe polymerization kinetics of acrylamide (AAm) initiated by the photoinitiator DAROCUR 2959 (DAR 2959 ) under UV light irradiation were investigated. Variations of polymerization rate with AAm concentration and conversion were studied. Under the present low monomer concentrations the gel effect as well the difusion-controlled termination reactions are expected to be postponed or suppressed. The polymerization rate vs. conversion curve of the photoinduced polymerization of AAm was described by two non-stationary rate intervals and the initial rate maximum. In both intervals the polymerization rate decreased with conversion and the decrease was much more pronounced in the low conversion region. Furthermore, the polymerization rate was observed to decrease with increasing monomer concentration. The polymerization behavior was discussed in terms of the intra and intermolecular chain transfer processes (mainly to backbiting) and the decrease of propagation rate coefficient with the monomer concentration. Furthermore, the chain transfer reactions including backbiting step initiate the formation of less reactive radicals and/or the retardation of the polymerizaton.

show abstract

“…33 Broth microdilution antibacterial assay was used to determine minimum inhibitory concentrations. The experiment was performed on strains of S. aureus subsp.…”

Section: Core-shell Gold-silver Nanoparticlesmentioning

confidence: 99%

“…Biocompatibility testing was performed using the MTS cell proliferation colorimetric assay, in which any significant effect on the proliferation of primary dermal fibroblasts following treatment with AuNP@Ag@Asm at different concentrations was not observed. 33 …”

Section: Core-shell Gold-silver Nanoparticlesmentioning

confidence: 99%

Laser thermal ablation of multidrug-resistant bacteria using functionalized gold nanoparticles

Mocan¹,

Tabaran²,

Mocan

et al. 2017

IJN

View full text Add to dashboard Cite

Aspartame-Stabilized Gold–Silver Bimetallic Biocompatible Nanostructures with Plasmonic Photothermal Properties, Antibacterial Activity, and Long-Term Stability

Cited by 144 publications

References 23 publications

Shell thickness-dependent antibacterial activity and biocompatibility of gold@silver core–shell nanoparticles

Shell thickness-dependent antibacterial activity and biocompatibility of gold@silver core–shell nanoparticles

Photopolymerization of acrylamide in the very low monomer concentration range

Laser thermal ablation of multidrug-resistant bacteria using functionalized gold nanoparticles

Contact Info

Product

Resources

About