Aspartame, Neotame and Advantame

O'Donnell, Kay

doi:10.1002/9781118373941.ch6

Cited by 12 publications

(10 citation statements)

References 15 publications

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“…The differences in the effect of xylitol between the two species could be from the different digestive or metabolic processes of the pentose molecules. Though not yet examined in insects, fewer carbon molecules are typically passed faster through intestinal membranes than hexose sugars [ 27 , 28 ]. The xylitol could be quickly absorbed and diffused through the midgut membrane in Z. cucurbitae , which may increase the osmotic pressure in the hemolymph before being excreted out.…”

Section: Discussionmentioning

confidence: 99%

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Insecticidal Properties of Erythritol on Four Tropical Tephritid Fruit Flies, Zeugodacus cucurbitae, Ceratitis capitata, Bactrocera dorsalis, and B. latifrons (Diptera: Tephritidae)

Dong

Skabeikis

Kim

et al. 2023

Insects

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Tephritid fruit flies are among the most destructive agricultural pests of fruits and vegetables worldwide and can impose trade barriers against the movement of fresh tropical commodities. Primary pre-harvest control methods for these flies rely on the spraying of conventional chemical insecticides or bait sprays. However, resistance to these control methods has been reported in fruit flies. Erythritol is a non-nutritive sugar alternative for human consumption, which has been tested and confirmed for its insecticidal properties against various insect pest species. In this study, using laboratory bioassays, we evaluated the insecticidal effect of erythritol alone or various erythritol formulations containing sucrose and/or protein on four tropical fruit fly species established in Hawaii (e.g., melon fly, Mediterranean fruit fly, oriental fruit fly, and Malaysian fruit fly). In addition, the effects of other non-nutritive hexose and pentose sugar alcohols, such as sorbitol, mannitol, and xylitol, were tested. Among the different standalone and combinatory treatments tested, 1M erythritol and a combinatory formulation of 2M erythritol + 0.5M sucrose appeared to be the most detrimental to the survival of all four species of tested flies, suggesting the potential of using erythritol as a non-toxic management tool for the control of tropical tephritid fruit flies.

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Section: Discussionmentioning

confidence: 99%

“…Though not yet examined in insects, fewer carbon molecules are typically passed faster through intestinal membranes than hexose sugars [27,28]. The xylitol could be quickly absorbed and diffused through the midgut membrane in Z. cucurbitae, which may increase the osmotic pressure in the hemolymph before being excreted out.…”

Section: Discussionmentioning

confidence: 99%

Insecticidal Properties of Erythritol on Four Tropical Tephritid Fruit Flies, Zeugodacus cucurbitae, Ceratitis capitata, Bactrocera dorsalis, and B. latifrons (Diptera: Tephritidae)

Dong

Skabeikis

Kim

et al. 2023

Insects

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“…To create the sugar sweetness index, we assumed that total sugar was equivalent in sweetness to sucrose (tabletop sugar). We selected sucrose because the sweetness is measured using reference solutions containing different sucrose concentrations in increasing amounts, and the sweetness of NNS is also measured in sucrose equivalents ( 10 , 32 – 37 ). To create the total sweetness index, we combined the sucrose equivalents from NNS purchases with the sucrose equivalents from total sugars purchased.…”

Section: Methodsmentioning

confidence: 99%

Did the sweetness of beverages change with the Chilean Food Labeling and Marketing Law? A before and after study

Rebolledo

Bercholz

et al. 2022

Front. Nutr.

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There has been a rapid proliferation of policies around the globe to reduce sugar consumption, yet there is little understanding as to whether these policies have led to changes in the overall sweetness of products, which is essential for understanding long-term effects on food preferences and intake. For example, the implementation of Chile’s Law on Food Labeling and Advertising led to decreases in the sugar content of non-alcoholic packaged beverages and increases in non-nutritive sweeteners (NNS) use in these beverages. Given that NNS have greater sweetness intensity than sugars, it is unclear what was the net effect of these changes on the sweetness of purchased beverages. Using longitudinal household purchase data (n > 2,000 households), we measured the changes in the sweetness of beverage purchases after implementing the first phase of the Chilean law and examine if there were differences by key family sociodemographic variables. We developed three sweetness indices: (1) NNS sweetness, including the sweetness of the six NNS most consumed by Chileans; (2) total sugars sweetness, including the sweetness from total sugars; and (3) total sweetness, combining the sweetness from NNS and sugars. Using fixed-effects models, we compared the observed post-law purchases to a counterfactual based on pre-law trends. We found that NNS sweetness increased relative to the counterfactual, while total sugars sweetness decreased after the law. However, the absolute changes in NNS sweetness were almost entirely offset by the decreases in total sugar sweetness, leading to no change in the total sweetness of beverage purchases. Additionally, there were no differences in the sweetness changes by family sociodemographics. Our findings indicate that Chilean consumers are exposed to similar sweetness levels in their beverages after the law. Future research should explore whether sweetness also remained consistent in dietary intake.

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“…Typically, sweeteners are employed in concentrations of 3 to 6% w / w , either individually or in combination. Mannitol, a polyhydric alcohol, is extensively utilized as a sugar alcohol sweetener in ODFs due to its ability to enhance the physical integrity of the dosage form [ 91 ]. Additionally, mannitol offers exceptional stability and compatibility with APIs and has a non-hygroscopic nature, which is advantageous for ensuring the long-term integrity and stability of the dosage form.…”

Section: Formulation Componentsmentioning

confidence: 99%

Orodispersible Films: Current Innovations and Emerging Trends

Jacob,

Boddu,

Bhandare

et al. 2023

Pharmaceutics

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Orodispersible films (ODFs) are thin, mechanically strong, and flexible polymeric films that are designed to dissolve or disintegrate rapidly in the oral cavity for local and/or systemic drug delivery. This review examines various aspects of ODFs and their potential as a drug delivery system. Recent advancements, including the detailed exploration of formulation components, such as polymers and plasticizers, are briefed. The review highlights the versatility of preparation methods, particularly the solvent-casting production process, and novel 3D printing techniques that bring inherent flexibility. Three-dimensional printing technology not only diversifies active compounds but also enables a multilayer approach, effectively segregating incompatible drugs. The integration of nanoparticles into ODF formulations marks a significant breakthrough, thus enhancing the efficiency of oral drug delivery and broadening the scope of the drugs amenable to this route. This review also sheds light on the diverse in vitro evaluation methods utilized to characterize ODFs, ongoing clinical trials, approved marketed products, and recent patents, providing a comprehensive outlook of the evolving landscape of orodispersible drug delivery. Current patient-centric approaches involve developing ODFs with patient-friendly attributes, such as improved taste masking, ease of administration, and enhanced patient compliance, along with the personalization of ODF formulations to meet individual patient needs. Investigating novel functional excipients with the potential to enhance the permeation of high-molecular-weight polar drugs, fragile proteins, and oligonucleotides is crucial for rapid progress in the advancing domain of orodispersible drug delivery.

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Aspartame, Neotame and Advantame

Cited by 12 publications

References 15 publications

Insecticidal Properties of Erythritol on Four Tropical Tephritid Fruit Flies, Zeugodacus cucurbitae, Ceratitis capitata, Bactrocera dorsalis, and B. latifrons (Diptera: Tephritidae)

Insecticidal Properties of Erythritol on Four Tropical Tephritid Fruit Flies, Zeugodacus cucurbitae, Ceratitis capitata, Bactrocera dorsalis, and B. latifrons (Diptera: Tephritidae)

Did the sweetness of beverages change with the Chilean Food Labeling and Marketing Law? A before and after study

Orodispersible Films: Current Innovations and Emerging Trends

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