Asociación entre concentraciones séricas de interleucina 10 y desarrollo de insuficiencia cardíaca en pacientes con infarto agudo de miocardio tratados con angioplastia primaria

Rodríguez, Alberto Domínguez; González, Pedro; González, Martín J. García; Hita, Julio Ferrer

doi:10.1157/13076414

Cited by 10 publications

(7 citation statements)

References 22 publications

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“…Therefore, it is reasonable to think that all the data relating glycaemic and HbA1c with HF development risk [5-8] could be explained based on the AGE-RAGE axis, since the glucose-fructosamine-HbA1c pathway ends in AGE [11] as pentosidine or carboxymethyl-lysine and these molecules can mediate myocardial remodelling towards cardiac dysfunction. In fact, in this study, glucose, fructosamine and HbA1c were predictors of post-infarction HF in the univariate analysis, but after the adjustment by confounding variables and AGE all of them lost their significance.…”

Section: Discussionmentioning

confidence: 99%

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Predictive value of advanced glycation end products for the development of post-infarction heart failure: a preliminary report

Raposeiras‐Roubín

Rodiño-Janeiro

Paradela-Dobarro

et al. 2012

Cardiovasc Diabetol

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BackgroundSince post-infarction heart failure (HF) determines a great morbidity and mortality, and given the physiopathology implications of advanced glycation end products (AGE) in the genesis of myocardial dysfunction, it was intended to analyze the prognostic value of these molecules in order to predict post-infarction HF development.MethodsA prospective clinical study in patients after first acute coronary syndrome was conducted. The follow-up period was consisted in 1 year. In 194 patients consecutively admitted in the coronary unit for myocardial infarct fluorescent AGE levels were measured. The association between glycaemic parameters and the development of post-infarction HF were analyzed in those patients. Finally, we identified the variables with independent predictor value by performing a multivariate analysis of Hazard ratio for Cox regression.ResultsEleven out of 194 patients (5.6%) developed HF during follow-up (median: 1.0 years [0.8 - 1.5 years]). Even though basal glucose, fructosamine and glycated haemoglobin were significant predictive factors in the univariate analysis, after being adjusted by confounding variables and AGE they lost their statistical signification. Only AGE (Hazard Ratio 1.016, IC 95%: 1.006-1.026; p<0,001), together with NT-proBNP and the infarct extension were predictors for post-infarction HF development, where AGE levels over the median value 5-fold increased the risk of HF development during follow-up.ConclusionsAGE are an independent marker of post-infarction HF development risk.

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Section: Discussionmentioning

confidence: 99%

“…There is also an inflammatory reaction with release of cytokines, growth factors and reactive oxygen species production [5], which contributes to perpetuate ventricular dysfunction and could have important implications for prognosis.…”

Section: Introductionmentioning

confidence: 99%

Predictive value of advanced glycation end products for the development of post-infarction heart failure: a preliminary report

Raposeiras‐Roubín

Rodiño-Janeiro

Paradela-Dobarro

et al. 2012

Cardiovasc Diabetol

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“…IL-10 has been identified to have immunomodulatory effects, which can facilitate cellular immunity, stimulate B cells to activate hyperplasia and release antibodies, and facilitate the proliferation and maturity of T cells (8,15). Based on the biological characteristics of IL-10, it is believed that IL-10 is a protective cytokine in CHF (16). Verma et al (17) reported that isoproterenol (ISO) was utilized to induce the myocardial hypertrophy HF model of wild-type and IL-10 gene knockout mice, and it was identified that the myocardial hypertrophic remodeling and cardiac function conditions of IL-10 gene knockout mice are more deteriorated than controls.…”

Section: Discussionmentioning

confidence: 99%

Effect of adenovirus mediated β2-AR overexpression on IL-10 level secreted by cardiomyocytes of heart failure rats

Lin

Cheng

Liu

et al. 2016

Experimental and Therapeutic Medicine

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The effect of β2-adrenergic receptor (AR) overexpression on interleukin (IL)-10 content secreted by cardiomyocytes of heart failure (HF) rats was investigated. A rat model of chronic HF was established by partially banding abdominal aorta and the cardiomyocytes were isolated with collagenase II. The cardiomyocytes were then transfected with adenovirus type 5-ADRβ2-enhanced green fluorescent protein (EGFP) for 48 h to observe the changes of β2-AR protein expression using western blot analysis. The IL-10 level was detected by ELISA. The experiment was divided into seven groups: Control, HF, HF+EGFP, HF+β2, sham, sham+EGFP and sham+β2 groups. Compared with the sham-operated group, left ventricular diastolic dimension, and left ventricular systolic dimension were increased (P<0.05), whereas ejection fraction and fractional shortening were decreased (P<0.05) in the HF group. Compared with the sham group, the cardiomyocyte survival rate of the HF group was significantly reduced (P<0.05). Compared with the control or sham group, the β2-AR protein level of the HF group showed no significant differences (P>0.05). Compared with the HF and HF+EGFP groups, the expression of β2-AR protein of cardiomyocytes was increased in the HF+β2 group (P<0.05). Compared with the sham group, IL-10 content secreted by cardiomyocytes in the HF group was increased (P<0.05). Compared with the HF and HF+EGFP groups, IL-10 content in the HF+β2 group was increased significantly (P<0.05). In conclusion, the concentration of IL-10 secreted by cardiomyocytes of HF rats was increased. The overexpression of β2-AR in the cardiomyocytes of HF rats was able to enhance the secretion of IL-10.

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“…As a result, the cytokines are removed from blood circulation without subsequent activation of the cells [11, 12]. This kind of decoy activity is thought to be of favorable contribution of IL-10 in ischemic heart after myocardial reperfusion, and it is likely to prevent against heart failure [13]. However, high level of IL-10 can also have an adverse effect by increasing the likelihood of sepsis.…”

Section: Discussionmentioning

confidence: 99%

The Effect of Conventional and Mini-Invasive Cardiopulmonary Bypass on Neutrophil Activation in Patients Undergoing Coronary Artery Bypass Grafting

Koláčková

Krejsek

Svitek

et al. 2012

Mediators of Inflammation

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Interleukin-10 (IL-10) is considered to be a cytokine with potent anti-inflammatory properties, which have been previously linked to increased incidence of sepsis. The level of IL-10 is elevated by cardiac surgery when cardiopulmonary bypass (CPB) and methylprednisolone are used. In our study, we compare the level of IL-10, IL-10 Receptor (IL-10R), and percentage of neutrophils between two groups of cardiac surgical patients undergoing Coronary Artery Bypass Grafting, both of which were not given methylprednisolone. The first group was operated with conventional CPB, while the second group was operated with minimally invasive CPB (mini-CPB). We detected enhanced level of IL-10 during surgery and at the end of surgery in both groups of patients. While no correlation between IL-10 and IL10R was found, IL-10 was positively correlated with increased percentage of neutrophils at the time points when the level of IL-10 peaked.

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Asociación entre concentraciones séricas de interleucina 10 y desarrollo de insuficiencia cardíaca en pacientes con infarto agudo de miocardio tratados con angioplastia primaria

Cited by 10 publications

References 22 publications

Predictive value of advanced glycation end products for the development of post-infarction heart failure: a preliminary report

Predictive value of advanced glycation end products for the development of post-infarction heart failure: a preliminary report

Effect of adenovirus mediated β2-AR overexpression on IL-10 level secreted by cardiomyocytes of heart failure rats

The Effect of Conventional and Mini-Invasive Cardiopulmonary Bypass on Neutrophil Activation in Patients Undergoing Coronary Artery Bypass Grafting

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