Asociación de tumores del estroma gastrointestinal con otros tumores primarios. Propuesta de una nueva clasificación

Hernández, Juan Ángel Fernández; Ripoll, Vicente Olivares; Paricio, Pascual Parrilla

doi:10.1016/j.medcli.2016.06.006

Cited by 3 publications

(2 citation statements)

References 45 publications

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“…The localization of GIST-associated neoplasias with the highest frequency in the gastrointestinal tract, the urogenital, and female genital tract is consistent with previously reported findings[20,21]. In addition to a possible common underlying predisposition, the probability of detecting even small GIST during staging examinations for gastrointestinal tract tumors might be higher than in cases of, for example, lung or head and neck tumors.…”

Section: Discussionsupporting

confidence: 90%

Frequency, localization, and types of gastrointestinal stromal tumor-associated neoplasia

Waidhauser¹,

Bornemann²,

Trepel

et al. 2019

WJG

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BACKGROUND In recent years, increasing evidence of second neoplasms associated with gastrointestinal stromal tumors (GIST) has been found. Numerous case reports, mostly retrospective studies and a few reviews, have been published. To our knowledge, however, no systematic review or meta-analysis of the existing data has been performed so far. AIM To prepare a compilation, as complete as possible, of all reported second tumor entities that have been described in association with GIST and to systematically analyze the published studies with regard to frequency, localization, and types of GIST-associated neoplasms. METHODS The MEDLINE and EBSCO databases were searched for a combination of the keywords GIST/secondary, synchronous, coincident/tumor, neoplasm, and relevant publications were selected by two independent authors. RESULTS Initially, 3042 publications were found. After deletion of duplicates, 1631 remained, and 130 papers were selected; 22 of these were original studies with a minimum of 20 patients, and 108 were case reports. In the 22 selected studies, comprising a total number of 12050 patients, an overall rate of GIST-associated neoplasias of 20% could be calculated. Most second neoplasias were found in the gastrointestinal tract (32%) and in the male and female urogenital tract (30%). The specific risk scores of GISTs associated with other tumors were significantly lower than those without associated neoplasias. CONCLUSION In this first systematic review, we could confirm previously reported findings of a more than coincidental association between GIST and other neoplasias. The question whether there is an underlying causal association will need further investigation. Our data suggest that even GIST with a very low risk of disease progression should prompt screening for second neoplasia and subsequent frequent controls or extended staging.

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Section: Discussionsupporting

confidence: 90%

Frequency, localization, and types of gastrointestinal stromal tumor-associated neoplasia

Waidhauser¹,

Bornemann²,

Trepel

et al. 2019

WJG

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“…In 2016, Fernández et al proposed a classification based on the temporal association between GISTs and other malignancies, dividing the patients into four types according to two main factors: which tumor was the index one, and if the associated neoplasm was synchronic or metachronic [22]. In 2018, the same authors first reported a series of patients diagnosed with GISTs associated with other SPTs, comparing the different subgroups of associated GISTs according to the proposed classification.…”

Section: Discussionmentioning

confidence: 99%

Association Between Gastrointestinal Stromal Tumors and Other Malignancies: It Is Only a Matter of Time ? A Case Series and an Overview of Systematic Reviews

Podda

Ferraro

Saverio

et al. 2019

J Gastrointest Canc

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Purpose Little is known about the sporadic coincidence of gastrointestinal stromal tumors (GISTs) with second primary tumors (SPTs). The aim of this study is to clarify if there is a clinicopathologic correlation responsible for the synchronous or metachronous occurrence of SPTs in GIST patients. Methods We carried out a single-center, retrospective analysis on patients with GISTs surgically treated at our institution from January 2019 to June 2019. Two groups of patients were identified: isolated GIST (group A) and GIST associated with SPT (group B). A meta-review was conducted with the aim to examine the published systematic reviews that included studies assessing the SPT risk in GIST patients. Results Thirty-nine patients were surgically treated for GIST during the study period, with seven (17.9%) of them having other SPTs. SPTs were most frequent in the colon. Group A patients had a lower mean age at initial diagnosis (56.8 ± 15.2 vs. 73.4 ± 16.6, P = 0.012). No statistically significant difference was found between the two groups in terms of tumor location, mitotic index, Ki-67 expression, risk classification, and imatinib therapy. The overview showed that the cumulative prevalence rate of SPTs ranged from 9.3 to 18.0%. SPTs were more frequent in the gastrointestinal tract (37.9-95.0%), followed by the genitourinary tract. Conclusion GIST patients under our care experienced a 17.9% overall risk of developing SPTs with different histology. When comparing patients with isolated GIST and patients with GIST and SPT, age was the only variable significantly related to the development of other neoplasms. However, the potential non-random association and causal relationship between GISTs and SPTs remain to be investigated.

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Additional malignancies in patients with gastrointestinal stromal tumors (GIST): incidence, pathology and prognosis according to a time of occurrence-based classification

et al. 2018

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Asociación de tumores del estroma gastrointestinal con otros tumores primarios. Propuesta de una nueva clasificación

Cited by 3 publications

References 45 publications

Frequency, localization, and types of gastrointestinal stromal tumor-associated neoplasia

Frequency, localization, and types of gastrointestinal stromal tumor-associated neoplasia

Association Between Gastrointestinal Stromal Tumors and Other Malignancies: It Is Only a Matter of Time ? A Case Series and an Overview of Systematic Reviews

Additional malignancies in patients with gastrointestinal stromal tumors (GIST): incidence, pathology and prognosis according to a time of occurrence-based classification

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