Asociación de los genotipos cagA, vacA e IceA de H. pylori con la gastritis crónica y folicular en una población colombiana con alto riesgo de cáncer gástrico

Carlosama-Rosero, Yeison Harvey; Bolaños-Bravo, H.; Sierra‐Torres, Carlos H.; Rosero, E.A.

doi:10.1016/j.rgmx.2018.03.004

Cited by 2 publications

(3 citation statements)

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“…In this study we analyzed the presence of Helicobacter pylori vacA , cagA , babA and sabA genotypes and their association with gastric malignancy precursor lesions and histological parameters in infected patients from southwestern Colombia. We found that the s1/m1 genotypes of the vacA and cagA + gene were more frequent in patients with PLGM, similar to previous studies in Colombia 10 , 11 . This finding suggests that the studied population has a high frequency of more virulent bacterial strains that could increase the risk of gastrointestinal diseases.…”

Section: Discussionsupporting

confidence: 91%

“…En este estudio analizamos la presencia de los genotipos vacA , cagA , babA y sabA de Helicobacter pylori y su asociación con las lesiones precursoras de malignidad gástrica y parámetros histológicos en pacientes infectados del suroccidente de Colombia. Se encontró que los genotipos s1/m1 del gen vacA y cagA + fueron más frecuente en los pacientes con LPMG, siendo similar a lo reportado por estudios previos en Colombia 10 , 11 . Este hallazgo sugiere que en la población de estudio existe una alta frecuencia de cepas bacterianas más virulentas que podrían aumentar el riesgo de enfermedades gastrointestinales.…”

Section: Discussionunclassified

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Genotipos de virulencia de Helicobacter pylori y su asociación con lesiones precursoras de malignidad gástrica y parámetros histológicos en pacientes colombianos

Acosta-Astaiza,

López-Sandoval,

Bonilla-Chaves

et al. 2023

Rev Peru Med Exp Salud Publica

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Se determinó la presencia de los genotipos de virulencia de Helicobacter pylori y su asociación con las lesiones precursoras de malignidad gástrica y parámetros histológicos en pacientes con síntomas de dispepsia del suroccidente de Colombia. Se realizó reacción en cadena de polimerasa (PCR) para la caracterización genética de vacA, cagA, babA2 y sabA. Se empleó la prueba de chi cuadrado o Fischer para evaluar la asociación de cada genotipo sobre el desenlace clínico. En los pacientes con lesiones precursorasde malignidad gástrica se encontró que el 86,3% presentaron el genotipo vacA s1/m1, el 68,1% cagA+ y los genotipos babA2+ y sabA+ con el 68,8% y 55,8%, respectivamente. También, se demostró la asociación entre los genotipos de virulencia y el grado severo de infiltración de células polimorfonucleares. Además, se encontró una asociación entre la combinación de los genes vacA/cagA, vacA/sabA y babA2/sabA. Este estudio proporciona evidencia acerca de la asociación de los genotipos de virulencia del H. pylori y la inflamación gástrica en pacientes infectados.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionunclassified

Genotipos de virulencia de Helicobacter pylori y su asociación con lesiones precursoras de malignidad gástrica y parámetros histológicos en pacientes colombianos

Acosta-Astaiza,

López-Sandoval,

Bonilla-Chaves

et al. 2023

Rev Peru Med Exp Salud Publica

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“…A positive association was found between the severity of these lesions and the cagA+/cagE+/vacA s 1 m 1 H. pylori genotype, while the cagA-/cagE-/vacA s 2 m 2 genotype was rare in patients with PN and GC and was more frequent in patients with NAG, which supports the relationship between histological features and H. pylori genotypes reported in previous studies. 35,71,74,75…”

Section: Discussionmentioning

confidence: 99%

Infection with Helicobacter Pylori Presenting the vacA s2m2 haplotype is Strongly Associated with Protection Against Gastric Cancer

Guevara-Tique¹,

Castro-Valencia²,

Olaya³

et al. 2021

Preprint

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Background: Infection with Helicobacter pylori is recognized as the main risk factor for gastric cancer (GC); the clinical outcome of this infection is variable and partially depends on the virulence of the infective strain. This study characterizes H. pylori virulence genes in patients with diverse gastric lesions, from preneoplasia to GC, from a South American region with high GC mortality rates.Methods: We studied the virulence profiles of H. pylori strains to colonize the antrum of 318 patients with non-atrophic gastritis (NAG), 58 patients with preneoplastic lesions (PN), and 90 with GC from Ibagué, Colombia. The presence of 16S rDNA, the cagA and cagE genes, and the vacA s1, s2, m1, and m2 alleles were determined by PCR.Results: H. pylori infection was detected in 44% of all patients, 41.2% in NAG, 43.1% in PN and 54.4% of GC patients (p= 0.0813). cagA and cagE genes were significantly more frequent in and GC than in NAG (p= <.0001). The vacA s1m1 haplotype was significantly more frequent in PN (68%) and GC (65.3%) than in NAG (37.4%). The frequency of vacA s2m2 haplotype decreased significantly from NAG (42.7%) to PN (12%) and this to GC (4.1%). A total of 23 different genotypes were identified, with cagA+/cagE+/vacA s1m1 (84/205) as the more frequent in PN and GC and cagA-/cagE-/vacA s2m2 in NAG (49/205).Conclusions: In the population studied, vacA s2m2 was identified as a significant marker for protection against PN and GC, and genotype cagA+/cagE+/vacA s1m1 as a marker for increased GC risk. We also found that patients with PN and GC had a higher frequency of cagA+/cagE+/vacA s1m1 H. pylori strains known to be aggressive.

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Asociación de los genotipos cagA, vacA e IceA de H. pylori con la gastritis crónica y folicular en una población colombiana con alto riesgo de cáncer gástrico

Abstract: The population studied had elevated frequencies of cytotoxic Helicobacter pylori strains and the iceA1 genotype was more frequent in follicular gastritis.

Cited by 2 publications

References 33 publications

Genotipos de virulencia de Helicobacter pylori y su asociación con lesiones precursoras de malignidad gástrica y parámetros histológicos en pacientes colombianos

Genotipos de virulencia de Helicobacter pylori y su asociación con lesiones precursoras de malignidad gástrica y parámetros histológicos en pacientes colombianos

Infection with Helicobacter Pylori Presenting the vacA s2m2 haplotype is Strongly Associated with Protection Against Gastric Cancer

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