Asociación de comorbilidades con infección sintomática y síndrome inflamatorio multisistémico por SARS-CoV-2 en niños

Prognostic factors for multisystem inflammatory syndrome in children: A systematic review and meta‐analysis

“…The database searches yielded 5183 records, of which 3081 were screened following deduplication. We retrieved 56 full‐texts for further screening, of which 12 observational studies were included for analysis (N = 18 024) 22–33 . A list of studies excluded during the full‐text screening phase can be found in Data S1.…”

“…Of the 12 included studies, reviewers judged 9 to have a high risk of bias 22,24,26,28–33 . The most frequent source of potential bias in these studies was related to the insufficient adjustment of important confounders in their multivariable regression models.…”

“…We retrieved 56 full-texts for further screening, of which 12 observational studies were included for analysis (N = 18 024). [22][23][24][25][26][27][28][29][30][31][32][33] A list of studies excluded during the full-text screening phase can be found in Data S1. The PRISMA flowchart for the study selection process is illustrated in Figure 1, and study characteristics are tabulated in Table S7.…”

“…Of the 12 included studies, reviewers judged 9 to have a high risk of bias. 22,24,26,[28][29][30][31][32][33] The most frequent source of potential bias in these studies was related to the insufficient adjustment of important confounders in their multivariable regression models. Other sources of bias included an insufficient number of events based on their number of tested predictors, improper dichotomisation of continuous variables, and the use of inappropriate model-building methods.…”

Dilatación temprana de arterias coronarias en síndrome inflamatorio multisistémico pediátrico (MIS-C) temporalmente asociado a SARS-CoV-2

“…Desde el inicio de la pandemia causada por el virus del síndrome respiratorio agudo severo 2 (SARS-CoV-2) se observó que un alto porcentaje de niños infectados son asintomáticos; sin embargo, un 6-10% de aquellos que requieren hospitalización presentan inflamación multisistémica grave con progresión a daño vascular y falla cardiaca [1][2][3] .…”